Catalog No.
YHB38501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val10-Ser117
Predicted molecular weight
14.35 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O76003
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PKCq-interacting protein, PKC-theta-interacting protein, Glutaredoxin-3, PKC-interacting cousin of thioredoxin, PICOT, GLRX3, Thioredoxin-like protein 2, TXNL2
The thioredoxin-like and one glutaredoxin domain are required to rescue the iron-starvation phenotype of HeLa GLRX3 knock out cells., PMID:40400140
Integrating multi-omics techniques and in vitro experiments reveals that GLRX3 regulates the immune microenvironment and promotes hepatocellular carcinoma cell proliferation and invasion through iron metabolism pathways., PMID:39654899
Core biomarkers analysis benefit for diagnosis on human intrahepatic cholestasis of pregnancy., PMID:39127651
Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis., PMID:37402774
Mating modifies the expression of crucial oxidative-reductive transcripts in the pig oviductal sperm reservoir: is the female ensuring sperm survival?, PMID:37351104
Unraveling the mechanism of [4Fe-4S] cluster assembly on the N-terminal cluster binding site of NUBP1., PMID:36916754
LncRNA FGF7-5 and lncRNA GLRX3 together inhibits the formation of carotid plaque via regulating the miR-2681-5p/ERCC4 axis in atherosclerosis., PMID:36071684
Prognostic Values of BolA Family Member Expression in Hepatocellular Carcinoma., PMID:36017386
Genomic basis of evolutionary adaptation in a warm-blooded fish., PMID:34984407
Polymorphisms of genes related to phase II metabolism and resistance to clopidogrel., PMID:34866404
GLRX3, a novel cancer stem cell-related secretory biomarker of pancreatic ductal adenocarcinoma., PMID:34794402
Genetic variants in histone modification regions are associated with the prognosis of lung adenocarcinoma., PMID:34728688
CircRNA ARFGEF1 functions as a ceRNA to promote oncogenic KSHV-encoded viral interferon regulatory factor induction of cell invasion and angiogenesis by upregulating glutaredoxin 3., PMID:33539420
TRIM16 protects human periodontal ligament stem cells from oxidative stress-induced damage via activation of PICOT., PMID:33091421
GLRX3 Acts as a [2Fe-2S] Cluster Chaperone in the Cytosolic Iron-Sulfur Assembly Machinery Transferring [2Fe-2S] Clusters to NUBP1., PMID:32429669
Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway., PMID:32414791
TRIAP1 knockdown sensitizes non-small cell lung cancer to ionizing radiation by disrupting redox homeostasis., PMID:32096592
PICOT binding to chromatin-associated EED negatively regulates cyclin D2 expression by increasing H3K27me3 at the CCND2 gene promoter., PMID:31527584
A PCBP1-BolA2 chaperone complex delivers iron for cytosolic [2Fe-2S] cluster assembly., PMID:31406370
Affinity Isolation and Mass Spectrometry Identification of Prostacyclin Synthase (PTGIS) Subinteractome., PMID:31226805
PICOT (GLRX3) is a positive regulator of stress-induced DNA-damage response., PMID:31176019
Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients., PMID:31011151
PICOT binding to the polycomb group protein, EED, alters H3K27 methylation at the MYT1 PRC2 target gene., PMID:30595380
[Proliferation and apoptosis of lung cancer cells regulated by gultaredoxin 3]., PMID:29860757
Glutaredoxin 3 promotes migration and invasion via the Notch signalling pathway in oral squamous cell carcinoma., PMID:29397791
A protein interaction network centered on leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) regulates growth factor receptors., PMID:29317492
Cytosolic iron chaperones: Proteins delivering iron cofactors in the cytosol of mammalian cells., PMID:28615454
Monoclonal Antibody Against Human GLRX3., PMID:28029331
Generation of Domain-Specific Monoclonal Antibodies Against Human Glutaredoxin3., PMID:27923109
Cytosolic iron-sulfur cluster transfer-a proposed kinetic pathway for reconstitution of glutaredoxin 3., PMID:27859051
A Glutaredoxin·BolA Complex Serves as an Iron-Sulfur Cluster Chaperone for the Cytosolic Cluster Assembly Machinery., PMID:27519415
Glutaredoxin 3 promotes nasopharyngeal carcinoma growth and metastasis via EGFR/Akt pathway and independent of ROS., PMID:27203742
Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway., PMID:26613676
N-terminal domains mediate [2Fe-2S] cluster transfer from glutaredoxin-3 to anamorsin., PMID:26302480
Human glutaredoxin 3 can bind and effectively transfer [4Fe-4S] cluster to apo-iron regulatory protein 1., PMID:26296460
CTRP3 Stimulates Proliferation and Anti-Apoptosis of Prostate Cells through PKC Signaling Pathways., PMID:26218761
Nuclear glutaredoxin 3 is critical for protection against oxidative stress-induced cell death., PMID:25975981
Thioredoxin-like protein 2b facilitates colon cancer cell proliferation and inhibits apoptosis via NF-κB pathway., PMID:25555669
Expression of thioredoxins and glutaredoxins in human hepatocellular carcinoma: correlation to cell proliferation, tumor size and metabolic syndrome., PMID:25004829
Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation., PMID:23615448
Caspase-3-mediated cleavage of PICOT in apoptosis., PMID:23415866
Thioredoxin-like protein 2 is overexpressed in colon cancer and promotes cancer cell metastasis by interaction with ran., PMID:23311631
A novel andrographolide derivative AL-1 exerts its cytotoxicity on K562 cells through a ROS-dependent mechanism., PMID:23161516
PICOT increases cardiac contractility by inhibiting PKCζ activity., PMID:22449794
Human glutaredoxin 3 forms [2Fe-2S]-bridged complexes with human BolA2., PMID:22309771
A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis., PMID:21575136
Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling., PMID:21123948
Widespread expression of PICOT in mouse and human tissues with predominant localization to epithelium., PMID:20498481
Characterization of the human monothiol glutaredoxin 3 (PICOT) as iron-sulfur protein., PMID:20226171
Hodgkin's lymphoma cells exhibit high expression levels of the PICOT protein., PMID:20170406
For research use only. Not for human or drug use.
