Catalog No.
YHB34901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Val397
Predicted molecular weight
47.72 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75908
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ACAT2, Cholesterol acyltransferase 2, Acyl-coenzyme A:cholesterol acyltransferase 2, SOAT2, ACAT-2, ACACT2, Sterol O-acyltransferase 2
Association of Increased SOAT2 Expression with Abnormal Cholesterol Esterification and Testosterone Deficiency in Late-Onset Hypogonadism Rats., PMID:40396327
Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2-mediated increase of SOAT2 RNA methylation., PMID:40227950
Avasimibe Abolishes the Efficacy of Fluvastatin for the Prevention of Cancer in a Spontaneous Mouse Model of Breast Cancer., PMID:40141147
Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity., PMID:39805872
ELAVL1-dependent SOAT2 exacerbated the pancreatitis-like cellular injury of AR42J cells induced by hyperstimulation with caerulein., PMID:39588852
Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase., PMID:39385005
Discovery of selective ACAT2 antagonist via a combination strategy based on deep docking, pharmacophore modelling, and molecular dynamics simulation., PMID:39316789
siRNA/CS-PLGA Nanoparticle System Targeting Knockdown Intestinal SOAT2 Reduced Intestinal Lipid Uptake and Alleviated Obesity., PMID:39297413
ACAT2 negatively modulated by FOXA2 suppresses ferroptosis to expedite the aggressive phenotypes of endometrial cancer cells., PMID:39077810
Additional mechanism for selective absorption of cholesterol and phytosterols., PMID:38964108
Comprehensive prognostic and immune analysis of sterol O-acyltransferase 1 in patients with hepatocellular carcinoma., PMID:38577529
Soat2 inhibitor avasimibe alleviates acute pancreatitis by suppressing acinar cell ferroptosis., PMID:38376541
ACAT2 may be a novel predictive biomarker and therapeutic target in lung adenocarcinoma., PMID:38213102
DNA Methylation of Genes Participating in Hepatic Metabolisms and Function in Fetal Calf Liver Is Altered by Maternal Undernutrition during Gestation., PMID:37445858
Identification of the prognostic value of Th1/Th2 ratio and a novel prognostic signature in basal-like breast cancer., PMID:36694223
Plasma FA composition in familial LCAT deficiency indicates SOAT2-derived cholesteryl ester formation in humans., PMID:35598637
HNF1A POU Domain Mutations Found in Japanese Liver Cancer Patients Cause Downregulation of HNF4A Promoter Activity with Possible Disruption in Transcription Networks., PMID:35327967
Soat2 ties cholesterol metabolism to β-oxidation and glucose tolerance in male mice., PMID:34982494
Molecular structures of human ACAT2 disclose mechanism for selective inhibition., PMID:34520735
High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer., PMID:34326474
Circ_RPL23A acts as a miR-1233 sponge to suppress the progression of clear cell renal cell carcinoma by promoting ACAT2., PMID:34036483
Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses., PMID:33980978
Alisol B 23-acetate activates ABCG5/G8 in the jejunum via the LXRα/ACAT2 pathway to relieve atherosclerosis in ovariectomized ApoE-/- mice., PMID:33234731
A Combination of Single Nucleotide Polymorphisms is Associated with the Interindividual Variability of Cholesterol Bioavailability in Healthy Adult Males., PMID:32996248
Gene expression in rat placenta after exposure to di(2-ethylhexyl) phthalate., PMID:32909833
Delineation of metabolic responses of Npc1-/-nih mice lacking the cholesterol-esterifying enzyme SOAT2 to acute treatment with 2-hydroxypropyl-β-cyclodextrin., PMID:32890578
Whole-exome sequencing and genome-wide association studies identify novel sarcopenia risk genes in Han Chinese., PMID:32478482
The Anti-atherogenic Activity of Beauveriolide Derivative BVD327, a Sterol O-Acyltransferase 2-Selective Inhibitor, in Apolipoprotein E Knockout Mice., PMID:32475917
Generation of new hepatocyte-like in vitro models better resembling human lipid metabolism., PMID:32058035
Comparative Effects and Mechanisms of Chitosan and Its Derivatives on Hypercholesterolemia in High-Fat Diet-Fed Rats., PMID:31877743
Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function., PMID:31727739
High-Fructose Diet-Induced Hypertriglyceridemia Is Associated With Enhanced Hepatic Expression of ACAT2 in Rats., PMID:31647302
Policosanol Attenuates Cholesterol Synthesis via AMPK Activation in Hypercholesterolemic Rats., PMID:31613687
Influence of dietary linseed oil as substitution of fish oil on whole fish fatty acid composition, lipid metabolism and oxidative status of juvenile Manchurian trout, Brachymystax lenok., PMID:31554849
Ontogenesis and Modulation of Intestinal Unesterified Cholesterol Sequestration in a Mouse Model of Niemann-Pick C1 Disease., PMID:31312996
The recent insights into the function of ACAT1: A possible anti-cancer therapeutic target., PMID:31228515
Acyl-CoA: cholesterol acyltransferases-2 gene polymorphism is associated with increased susceptibility to coronary artery disease in Uygur population in Xinjiang, China., PMID:30696703
Genetic depletion of Soat2 diminishes hepatic steatosis via genes regulating de novo lipogenesis and by GLUT2 protein in female mice., PMID:30630736
Determination of Penicillium griseofulvum-oriented pyripyropene A, a selective inhibitor of acyl-coenzyme A:cholesterol acyltransferase 2, in mouse plasma using liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies., PMID:30238481
Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307., PMID:30177721
Modulation of Rat Liver Regeneration after Partial Hepatectomy by Dietary Cholesterol., PMID:30012246
Overexpression of transforming growth factor β induced factor homeobox 1 represses NPC1L1 and lowers markers of intestinal cholesterol absorption., PMID:29980051
Intake of Baked Cod Fillet Resulted in Lower Serum Cholesterol and Higher Long Chain n-3 PUFA Concentrations in Serum and Tissues in Hypercholesterolemic Obese Zucker fa/fa Rats., PMID:29958397
Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population., PMID:29945935
Niemann-Pick C1-deficient mice lacking sterol O-acyltransferase 2 have less hepatic cholesterol entrapment and improved liver function., PMID:29878847
Inhibition of miR-486 and miR-92a decreases liver and plasma cholesterol levels by modulating lipid-related genes in hyperlipidemic hamsters., PMID:29725814
[Effect of leech on lipid metabolism and liver in hyperlipidemia rats]., PMID:29600657
Fatty acids modulate the expression levels of key proteins for cholesterol absorption in Caco-2 monolayer., PMID:29463265
Cranberry anthocyanin as an herbal medicine lowers plasma cholesterol by increasing excretion of fecal sterols., PMID:29425660
Design and Synthesis of A-Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors., PMID:29323466
For research use only. Not for human or drug use.
