Catalog No.
DHD85404
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Humanized
Isotype
IgG1-kappa
Clonality
Monoclonal
Target
sCD40L, Tumor necrosis factor ligand superfamily member 5, T-cell antigen Gp39, CD40L, TNFSF5, CD154, CD40-L, TNF-related activation protein, CD40 ligand, CD40LG, TRAP
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P29965
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
E6040, IDEC-131, CAS: 252662-47-8
Clone ID
Toralizumab
IDEC-131. IDEC/Eisai, PMID: 12090546
Update on clinical trials in systemic lupus erythematosus, PMID: 27314466
Systemic lupus erythematosus: an update on current pharmacotherapy and future directions, PMID: 23339281
Preemptive CD20+ B cell Depletion Attenuates Cardiac Allograft Vasculopathy in CD154-Treated Monkeys, PMID: 27362307
The effect of anti-CD40 ligand in immune thrombocytopenic purpura, PMID: 18341638
CD154 regulates primate humoral immunity to influenza, PMID: 12780559
Comparative Evaluation of αCD40 (2C10R4) and αCD154 (5C8H1 and IDEC-131) in a Nonhuman Primate Cardiac Allotransplant Model, PMID: 28557955
IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates, PMID: 15816883
Alloimmunity in primate heart recipients with CD154 blockade: evidence for alternative costimulation mechanisms, PMID: 16436970
Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation, PMID: 12594309
Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thrombocytopenic purpura, PMID: 14551140
For research use only. Not for human or drug use.
