Catalog No.
YHB33401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu414
Predicted molecular weight
48.97 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75874
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IDH1, IDH, NADP(+)-specific ICDH, Isocitrate dehydrogenase [NADP] cytoplasmic, PICD, IDP, Cytosolic NADP-isocitrate dehydrogenase, Oxalosuccinate decarboxylase
Blocking mutant IDH1 phosphorylation triggers APC/C CDH1-dependent ubiquitination in mitotic cells., PMID:40513618
R-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity., PMID:40498073
Single Cell Spatial Profiling Identifies Region-Specific Extracellular Matrix Adhesion and Signaling Networks in Glioblastoma., PMID:40496929
[Update of molecular pathology in cartilage tumors]., PMID:40494758
In-depth characterization of vaccine-induced neoantigen-specific T cells in patients with IDH1-mutant glioma undergoing personalized peptide vaccination., PMID:40480654
Beyond the Promoter: Total MGMT Gene Methylation Modulates Response to DNA Alkylating Agents in Glioma., PMID:40464417
Multiplexed Data-Independent Acquisition (mDIA) to Profile Extracellular Vesicle Proteomes., PMID:40462888
Establishment and characterization of TK-DDCS1: a novel IDH1 mutated dedifferentiated chondrosarcoma cell line., PMID:40459681
Panoramic spatial enhanced resolution proteomics (PSERP) reveals tumor architecture and heterogeneity in gliomas., PMID:40420200
A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas., PMID:40418677
Anatomical heterogeneity in low-grade and high-grade gliomas: A multiscale perspective., PMID:40409387
IDH1/MDH1 deacetylation activates the cGAS-STING pathway by promoting NETosis in acute liver failure., PMID:40388861
Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis., PMID:40378837
Mutant IDH1 cooperates with NPM1c or FLT3ITD to drive distinct myeloid diseases and molecular outcomes., PMID:40377995
IDH mutation and MGMT methylation status in glioblastoma and other gliomas patients: a Russian retrospective cohort study., PMID:40377745
ALYREF Promotes Progression of Intrahepatic Cholangiocarcinoma through Increasing the Level of Isocitrate Dehydrogenase 1 in an m5C-Dependent Manner., PMID:40369958
LSM2 drives glioma progression through alternative splicing dysregulation: a multi-omics approach to identify a potential therapeutic target., PMID:40365337
Semisupervised adaptive learning models for IDH1 mutation status prediction., PMID:40323991
GSK3 acts as a switch for transcriptional programs in a model of low-grade gliomagenesis., PMID:40307935
Understanding the IDH1 missense SNPs on expression of genes involved in Glioblastoma multiforme., PMID:40306098
Correlation between Isocitrate Dehydrogenase Mutation and Immunohistochemical Expression of DNA Mismatch Repair Proteins in the Prognosis of Gliomas., PMID:40302099
IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming., PMID:40299922
From pixels to prognosis: leveraging radiomics and machine learning to predict IDH1 genotype in gliomas., PMID:40299088
A review of epilepsy syndromes and epileptogenic mechanism affiliated with brain tumor related genes., PMID:40294709
[Metabolism and therapy in acute myeloid leukemia with isocitrate dehydrogenase 1/2 mutations]., PMID:40294295
Metabolic reprogramming in glioblastoma: a rare case of recurrence to scalp metastasis., PMID:40274950
Assessing the diagnostic, prognostic, and therapeutic potential of the somatostatin/cortistatin system in glioblastoma., PMID:40268793
Integrated analysis of transcriptional and metabolic responses to mitochondrial stress., PMID:40233762
Protein Phosphatase 1 Regulatory Subunit 3C integrates cholesterol metabolism and isocitrate dehydrogenase in chondrocytes and neoplasia., PMID:40232792
Recent Developments in Differentiation Therapy of Acute Myeloid Leukemia., PMID:40227641
Targeted therapy for pediatric glioma: RAF(t)ing in the molecular era., PMID:40227462
Gene Mutation Characteristics and Prognostic Significance in Acute Myeloid Leukemia Patients From Northeast China., PMID:40226311
Cancer genetic profile and risk of thrombosis., PMID:40221227
Claudin 18.2: a promising actionable target in biliary tract cancers., PMID:40215597
Catalytically distinct metabolic enzyme isocitrate dehydrogenase 1 mutants tune phenotype severity in tumor models., PMID:40188944
Reviewing the IDH1 Mutation-Mediated Mechanism of Drug Resistance and Revisiting Its Overcoming Strategies., PMID:40183465
Isocitrate dehydrogenase 1 gene mutations: a case review unveiling its biological impact on disease progression, prognosis and treatment in Chilean patients., PMID:40182999
Characteristics, outcome, and prognostic factors of young patients with central nervous system World Health Organization grade 3 oligodendrogliomas IDH-mutant and 1p/19q codeleted: A French POLA network study., PMID:40159303
Predicting postoperative recurrence and survival in glioma patients using enhanced MRI-based delta habitat radiomics: an 8-year retrospective pilot study., PMID:40155892
BH3 mimetics augment cytotoxic T cell killing of acute myeloid leukemia via mitochondrial apoptotic mechanism., PMID:40140361
Targeting PDGFRA-SHP2 Signaling Enhances Radiotherapy in IDH1-Mutant Glioma., PMID:40128633
Brain tumor intelligent diagnosis based on Auto-Encoder and U-Net feature extraction., PMID:40127071
Establishment and characterization of NCC-dCS2-C1: a novel patient-derived cell line of dedifferentiated chondrosarcoma., PMID:40126770
VCP Promotes Cholangiocarcinoma Development by Mediating BAP1 Ubiquitination-Dependent Degradation., PMID:40122668
Genomic Characterization of Chondrosarcoma Reveals Potential Therapeutic Targets., PMID:40117529
Highly infiltrative brain metastasis of RET mutant lung primary: Morphometric assessment and molecular review., PMID:40116187
Effect of NPM1 Mutation Subtype and Co-Mutation Patterns on the Outcomes of Acute Myeloid Leukemia., PMID:40103515
Phase I Study of the Mutant IDH1 Inhibitor Ivosidenib: Long-term Safety and Clinical Activity in Patients with Conventional Chondrosarcoma., PMID:40100120
A retrospective study of outcomes across time and treatment regimens in newly diagnosed, FMS-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukemia., PMID:40097915
Metformin attenuates myocardial ischemia/reperfusion-induced ferroptosis through the upregulation of Nur77-mediated IDH1., PMID:40096893
For research use only. Not for human or drug use.
