Catalog No.
YHB32101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Trp277
Predicted molecular weight
33.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75828
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Carbonyl reductase [NADPH] 3, Short chain dehydrogenase/reductase family 21C member 2, NADPH-dependent carbonyl reductase 3, CBR3
Drugs Metabolism-Related Genes Variants Impact on Anthracycline-Based Chemotherapy Induced Subclinical Cardiotoxicity in Breast Cancer Patients., PMID:40362292
The impact of CBR3 (rs1056892) and ABCC1 (rs45511401) genetic polymorphisms on doxorubicin-induced cardiotoxicity and the potential role of brain natriuretic peptide as an early cardiac biomarker in breast cancer patients., PMID:40207889
Influence of Polymorphisms in Pharmacokinetics-Related Genes on the Areas Under the Plasma Concentration-Time Curves of Doxorubicin and Doxorubicinol in Patients with Diffuse Large B-Cell Lymphoma Receiving CHOP Therapy., PMID:40186087
RBM15 recruits myeloid-derived suppressor cells via the m6A-IGF2BP3/CBR3-AS1/miR-409-3p/CXCL1 axis, facilitating radioresistance in non-small-cell lung cancer., PMID:39962467
Genetic variation perspective reveals potential drug targets for subtypes of endometrial cancer., PMID:39548148
Integrated machine learning and bioinformatic analysis of mitochondrial-related signature in chronic rhinosinusitis with nasal polyps., PMID:39328210
Multi-omics characterization of type 2 diabetes mellitus-induced gastroenteropathy in the db/db mouse model., PMID:39211388
Regulatory role of PDK1 via integrated gene analysis of mitochondria-immune response in periodontitis., PMID:38657876
Quantitative Analysis of mRNA and Protein Expression Levels of Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoforms in the Human Intestine., PMID:37722844
Genes of Predisposition to Childhood Beta-Cell Acute Lymphoblastic Leukemia in the Kazakh Population., PMID:37642051
PHF20 is a Novel Prognostic Biomarker and Correlated with Immune Status in Breast Cancer., PMID:36598702
LncRNA CBR3-AS1 predicts a poor prognosis and promotes cervical cancer progression through the miR-3163/LASP1 pathway., PMID:36591804
Identification of Small Airway Epithelium-Related Hub Genes in Chronic Obstructive Pulmonary Disease., PMID:36475041
Yangyinqingfei decoction attenuates PM2.5-induced lung injury by enhancing arachidonic acid metabolism., PMID:36467030
Identification of expression of CCND1-related lncRNAs in breast cancer., PMID:35803208
CBR3-AS1 Accelerates the Malignant Proliferation of Gestational Choriocarcinoma Cells by Stabilizing SETD4., PMID:35655916
Bioinformatics detection of modulators controlling splicing factor-dependent intron retention in the human brain., PMID:35391504
Long Non-coding RNA CBR3 Antisense RNA 1 is Downregulated in Colorectal Cancer and Inhibits miR-29a-Mediated Cell Migration and Invasion., PMID:35107754
Long noncoding RNA CBR3-AS1 mediates tumorigenesis and radiosensitivity of non-small cell lung cancer through redox and DNA repair by CBR3-AS1 /miR-409-3p/SOD1 axis., PMID:34801596
Long Non-Coding RNAs Expression in Breast Cancer: CBR3-AS1 LncRNA as a Sensitive Biomarker., PMID:34582659
Association of genetic polymorphisms NCF4 rs1883112, CBR3 rs1056892, and ABCC1 rs3743527 with the cardiotoxic effects of doxorubicin in children with acute lymphoblastic leukemia., PMID:34096893
Environmental and Genetic Factors in the Pathogenesis of COPD in the Road-Working Population., PMID:34012494
Cisplatin and phenanthriplatin modulate long-noncoding RNA expression in A549 and IMR90 cells revealing regulation of microRNAs, Wnt/β-catenin and TGF-β signaling., PMID:34001990
The genetic underpinnings of anthracycline-induced cardiomyopathy predisposition., PMID:33871046
The interaction between miRNAs/lncRNAs and Notch pathway in human disorders., PMID:33743335
LncRNA CBR3-AS1 regulates of breast cancer drug sensitivity as a competing endogenous RNA through the JNK1/MEK4-mediated MAPK signal pathway., PMID:33494806
Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer., PMID:33445170
Quantitative analysis of mRNA expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in human livers., PMID:33036882
Long noncoding RNA CBR3 antisense RNA 1 promotes the aggressive phenotypes of non‑small‑cell lung cancer by sponging microRNA‑509‑3p and competitively upregulating HDAC9 expression., PMID:32945466
Carbonyl Reductase 1 Plays a Significant Role in Converting Doxorubicin to Cardiotoxic Doxorubicinol in Mouse Liver, but the Majority of the Doxorubicinol-Forming Activity Remains Unidentified., PMID:31955137
Expression of Human PTEN-L in a Yeast Heterologous Model Unveils Specific N-Terminal Motifs Controlling PTEN-L Subcellular Localization and Function., PMID:31779149
Identification of gene and microRNA changes in response to smoking in human airway epithelium by bioinformatics analyses., PMID:31568004
Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response., PMID:31377417
Impact of protocol change on individual factors related to course of adverse reactions to chemotherapy for breast cancer., PMID:31056713
Carbonyl reductase sniffer from the model organism daphnia: Cloning, substrate determination and inhibitory sensitivity., PMID:30991043
Effects of JUN and NFE2L2 knockdown on oxidative status and NFE2L2/AP-1 targets expression in HeLa cells in basal conditions and upon sub-lethal hydrogen peroxide treatment., PMID:30515697
NOS3 895G>T and CBR3 730G>A Are Associated with Recurrence Risk in Non-Muscle-Invasive Bladder Cancer with Intravesical Instillations of THP., PMID:30125887
PlncRNA-1 is overexpressed in retinoblastoma and regulates retinoblastoma cell proliferation and motility through modulating CBR3., PMID:30096220
Carbonyl reductases from Daphnia are regulated by redox cycling compounds., PMID:29893480
Screening of potential biomarkers in uterine leiomyomas disease via gene expression profiling analysis., PMID:29568968
LncRNA CBR3-AS1 predicts unfavorable prognosis and promotes tumorigenesis in osteosarcoma., PMID:29554595
Low-Dose Anthracycline and Risk of Heart Failure in a Pharmacokinetic Model of Human Myocardium Exposure: Analog Specificity and Role of Secondary Alcohol Metabolites., PMID:29222131
Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin., PMID:29117945
Genome-wide association study of cardiotoxicity in the NCCTG N9831 (Alliance) adjuvant trastuzumab trial., PMID:28763429
The role of carbonyl reductase 1 in drug discovery and development., PMID:28712324
Metastatic triple-negative breast cancer patient with TP53 tumor mutation experienced 11 months progression-free survival on bortezomib monotherapy without adverse events after ending standard treatments with grade 3 adverse events., PMID:28679691
Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs., PMID:28450226
Native Mass Spectrometry of Recombinant Proteins from Crude Cell Lysates., PMID:28345863
Population pharmacokinetics of Daunorubicin in adult patients with acute myeloid leukemia., PMID:27738808
Coregulation of tandem duplicate genes slows evolution of subfunctionalization in mammals., PMID:27199432
For research use only. Not for human or drug use.
