Catalog No.
YHB30901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu299
Predicted molecular weight
35.70 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75792
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RNase H2 subunit A, RNHIA, RNASEHI, RNase HI large subunit, Ribonuclease HI subunit A, Ribonuclease H2 subunit A, AGS4, RNASEH2A, Aicardi-Goutieres syndrome 4 protein, RNase H(35), Ribonuclease HI large subunit
An overview of genetic mutations in Aicardi-Goutières syndrome in Iranian population., PMID:39470906
Systemic complications of Aicardi Goutières syndrome using real-world data., PMID:39332260
Second generation lethality in RNAseH2a knockout zebrafish., PMID:39217460
Transcriptomic analysis of different intramuscular fat contents on the flavor of the longissimus dorsi tissues from Guangling donkey., PMID:39084475
Monogenic interferon-mediated diseases: novel phenotype and genotype characteristics from a Saudi population., PMID:38976295
SAMHD1 compound heterozygous rare variants associated with moyamoya and mitral valve disease in the absence of other features of Aicardi-Goutières syndrome., PMID:38041217
Identification of DNA damage response-related genes as biomarkers for castration-resistant prostate cancer., PMID:37950047
Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma., PMID:37903971
Aicardi-Goutières syndrome: A monogenic type I interferonopathy., PMID:37515439
In Silico Characterization of RNASEH2A Pathogenic Variants and Identification of Novel Splice Site Donor Variant c.549+1G>T in Indian Population., PMID:37456470
Ribonuclease H2 Subunit A Preserves Genomic Integrity and Promotes Prostate Cancer Progression., PMID:36923313
Transcription Factor ELK3 Promotes Stemness and Oxaliplatin Resistance of Glioma Cells by Regulating RNASEH2A., PMID:36638810
Characterization of Mitochondrial Alterations in Aicardi-Goutières Patients Mutated in RNASEH2A and RNASEH2B Genes., PMID:36430958
Identification and verification of a 4-gene signature predicting the overall survival of cervical cancer., PMID:36281082
Association of rare variants in genes of immune regulation with pediatric autoimmune CNS diseases., PMID:35960392
Analysis of clinical characteristics of children with Aicardi-Goutieres syndrome in China., PMID:35551623
Exploring Potential Regulatory Anesthetic Drugs Based on RNA Binding Protein and Constructing CESC Prognosis Model: A Study Based on TCGA Database., PMID:35449547
Genetic screening of early-onset patients with systemic lupus erythematosus by a targeted next-generation sequencing gene panel., PMID:35086391
Expression profile of RNA binding protein in cervical cancer using bioinformatics approach., PMID:34863153
Hypoxia-induced RNASEH2A limits activation of cGAS-STING signaling in HCC and predicts poor prognosis., PMID:34165025
Gene Co-Expression Analysis of Human RNASEH2A Reveals Functional Networks Associated with DNA Replication, DNA Damage Response, and Cell Cycle Regulation., PMID:33805806
Role of Amygdalin in Blocking DNA Replication in Breast Cancer In Vitro., PMID:33535947
PNPT1 mutations may cause Aicardi-Goutières-Syndrome., PMID:33158637
An integrative multi-omics network-based approach identifies key regulators for breast cancer., PMID:33133424
Identification of RNA-Binding Proteins as Targetable Putative Oncogenes in Neuroblastoma., PMID:32707690
Identification of hub genes in hepatocellular carcinoma using integrated bioinformatic analysis., PMID:32213663
Generation of three induced pluripotent cell lines (iPSCs) from an Aicardi-Goutières syndrome (AGS) patient harboring a deletion in the genomic locus of the sterile alpha motif and HD domain containing protein 1 (SAMHD1)., PMID:32062129
Neuropathological Findings in a Case of IFIH1-Related Aicardi-Goutières Syndrome., PMID:30952201
Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1., PMID:30696738
DNA damage and reactive oxygen species cause cell death in the rice local lesions 1 mutant under high light and high temperature., PMID:30449034
Prognostic Value of RNASEH2A-, CDK1-, and CD151-Related Pathway Gene Profiling for Kidney Cancers., PMID:29843367
Astrocytes, an active player in Aicardi-Goutières syndrome., PMID:29740948
Interplay between RNASEH2 and MOV10 controls LINE-1 retrotransposition., PMID:29315404
MDA5-Associated Neuroinflammation and the Singleton-Merten Syndrome: Two Faces of the Same Type I Interferonopathy Spectrum., PMID:28475458
Interferon-Stimulated Gene Expression as a Preferred Biomarker for Disease Activity in Aicardi-Goutières Syndrome., PMID:28387595
Integrative analysis for identification of shared markers from various functional cells/tissues for rheumatoid arthritis., PMID:27812736
Neurologic Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, and IFIH1: Aicardi-Goutières Syndrome and Beyond., PMID:27643693
RNaseH2A is involved in human gliomagenesis through the regulation of cell proliferation and apoptosis., PMID:27176716
RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice., PMID:26880576
Gene expression profiling analysis of lung adenocarcinoma., PMID:26840709
Is the role of human RNase H2 restricted to its enzyme activity?, PMID:26603688
Phenotypic variation in Aicardi-Goutières syndrome explained by cell-specific IFN-stimulated gene response and cytokine release., PMID:25769924
Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1., PMID:25604658
A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes., PMID:25411967
Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study., PMID:24183309
Synonymous mutations in RNASEH2A create cryptic splice sites impairing RNase H2 enzyme function in Aicardi-Goutières syndrome., PMID:23592335
Chronic exposure of astrocytes to interferon-α reveals molecular changes related to Aicardi-Goutieres syndrome., PMID:23365100
For research use only. Not for human or drug use.
