Catalog No.
YHB25401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Phe348
Predicted molecular weight
41.24 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75582
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RPS6KA5, RSK-like protein kinase, MSK1, Ribosomal protein S6 kinase alpha-5, Nuclear mitogen- and stress-activated protein kinase 1, 90 kDa ribosomal protein S6 kinase 5, RSKL, S6K-alpha-5
MSK1 promotes colorectal cancer metastasis by increasing Snail protein stability through USP5-mediated Snail deubiquitination., PMID:40164688
Transcriptomic Evidence Reveals the Dysfunctional Mechanism of Synaptic Plasticity Control in ASD., PMID:39858558
Activation of MSK-1 exacerbates neuropathic pain through histone H3 phosphorylation in the rats' dorsal root ganglia and spinal dorsal horn., PMID:39557219
Involvement of mitogen- and stress-activated protein kinase 1 in BMP-6-induced chondrocyte differentiation., PMID:39307301
MSK1 is required for the experience- and ampakine-dependent enhancement of spatial reference memory and reversal learning and for the induction of Arc and BDNF., PMID:39128584
Establishing a carcinoembryonic antigen-associated competitive endogenous RNA network and forecasting an important regulatory axis in colon adenocarcinoma patients., PMID:38482222
Interruption of p38MAPK-MSK1-CREB-MITF-M pathway to prevent hyperpigmentation in the skin., PMID:38481807
Associations of MSK1 Methylation and Executive Function With Suicidal Ideation in Adolescents With Major Depressive Disorder: A Prospective Cohort Study., PMID:38385994
Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer., PMID:38012744
MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan., PMID:37432063
The histamine H3 receptor modulates dopamine D2 receptor-dependent signaling pathways and mouse behaviors., PMID:36871761
Mir-421 and mir-550a-1 are potential prognostic markers in esophageal adenocarcinoma., PMID:36829221
Mitogen- and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states., PMID:36812480
[Mechanism of Shaofu Zhuyu Decoction in treatment of endometriosis-associated dysmenorrhea with syndrome of cold coagulation and blood stasis based on MSK1/2]., PMID:36164874
Curcumin Upregulates miR-148a to Increase the Chemosensitivity of CD44-Positive Prostate Cancer Stem Cells to Paclitaxel Through Targeting the MSK1/IRS1 axis., PMID:35868335
Identification of differentially expressed genes, transcription factors, microRNAs and pathways in neutrophils of sepsis patients through bioinformatics analysis., PMID:35818227
β-glucan-coupled superparamagnetic iron oxide nanoparticles induce trained immunity to protect mice against sepsis., PMID:34976207
Overexpressed mitogen-and stress-activated protein kinase 1 promotes the resistance of cytarabine in acute myeloid leukemia through brahma related gene 1-mediated upregulation of heme oxygenase-1., PMID:34953799
Improvement of Astragalin on Spermatogenesis in Oligoasthenozoospermia Mouse Induced by Cyclophosphamide., PMID:34846706
Hippocampal MSK1 regulates the behavioral and biological responses of mice to chronic social defeat stress: Involving of the BDNF-CREB signaling and neurogenesis., PMID:34774532
MicroRNA Dysregulation in the Hippocampus of Rats with Noise-Induced Hearing Loss., PMID:34527169
Mitogen and Stress-Activated Kinases 1 and 2 Mediate Endothelial Dysfunction., PMID:34445361
Mitogen-induced transcriptional programming in human fibroblasts., PMID:34274479
LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions., PMID:34083438
The influence of sensory experience on the glutamatergic synapse., PMID:34048870
MSK1 downregulation is involved in inflammatory responses following subarachnoid hemorrhage in rats., PMID:33732337
Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1., PMID:33709453
14q32.11 microdeletion including CALM1, TTC7B, PSMC1, and RPS6KA5: A new potential cause of developmental and language delay in three unrelated patients., PMID:33634591
Epidermal growth factor upregulates the expression of A20 in hepatic cells via the MEK1/MSK1/p-p65 (Ser276) signaling pathway., PMID:33594320
Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase., PMID:33563994
Overexpression of the MSK1 Kinase in Patients With Chronic Lung Allograft Dysfunction and Its Confirmed Role in a Murine Model., PMID:33560725
Peptide/Lipid-Associated Nucleic Acids (PLANAs) as a Multicomponent siRNA Delivery System., PMID:33496597
Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model., PMID:33450992
Schizophyllum commune β-glucan: Effect on interleukin-10 expression induced by lipopolysaccharide from periodontopathic bacteria., PMID:33278951
Mitogen and Stress-activated Protein Kinase 1 Negatively Regulates Hippocampal Neurogenesis., PMID:33246062
Mitogen- and stress-activated protein kinase-1 activation is involved in melanocortin-induced BDNF expression in Neuro2a neuronal cells., PMID:32815825
Mitogen- and Stress-Activated Protein Kinase 1 Mediates Alcohol-Upregulated Transcription of Brf1 and tRNA Genes to Cause Phenotypic Alteration., PMID:32685086
Tumor dormancy in bone., PMID:32632400
Dehydration stress alters the mitogen-activated-protein kinase signaling and chaperone stress response in Xenopus laevis., PMID:32497588
Experience Recruits MSK1 to Expand the Dynamic Range of Synapses and Enhance Cognition., PMID:32376781
Mycosporine-like amino acids stimulate hyaluronan secretion by up-regulating hyaluronan synthase 2 via activation of the p38/MSK1/CREB/c-Fos/AP-1 axis., PMID:32284328
STAT3 activates MSK1-mediated histone H3 phosphorylation to promote NFAT signaling in gastric carcinogenesis., PMID:32041943
A panel of autoantibodies against tumor-associated antigens in the early immunodiagnosis of lung cancer., PMID:31980218
Discovering novel lung cancer associated antigens and the utilization of their autoantibodies in detection of lung cancer., PMID:31839396
Heterogeneity and Plasticity of Human Breast Cancer Cells in Response to Molecularly-Targeted Drugs., PMID:31681603
Protective Effect of Mitogen- and Stress-Activated Protein Kinase on the Rats with Focal Ischemia-Reperfusion Injury., PMID:31529230
Mechanisms Underlying the Functional Cooperation Between PPARα and GRα to Attenuate Inflammatory Responses., PMID:31447832
An Angle on MK2 Inhibition-Optimization and Evaluation of Prevention of Activation Inhibitors., PMID:31325352
MicroRNA-130a Contributes to Type-2 Classical DC-activation in Sjögren's Syndrome by Targeting Mitogen- and Stress-Activated Protein Kinase-1., PMID:31281310
MSK1 promotes cell proliferation and metastasis in uveal melanoma by phosphorylating CREB., PMID:32864007
For research use only. Not for human or drug use.
