Catalog No.
YHB22801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ile209
Predicted molecular weight
50.40 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75496
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Geminin, GMNN
Integrating single-cell RNA sequencing, WGCNA, and machine learning to identify key biomarkers in hepatocellular carcinoma., PMID:40169794
Bioinformatic Insights and XGBoost Identify Shared Genetics in Chronic Obstructive Pulmonary Disease and Type 2 Diabetes., PMID:40045538
Multiple mechanisms for licensing human replication origins., PMID:39604729
Evaluation of BUBR1, MCM2, and GMNN as oral cancer biomarkers., PMID:39480819
New insight into the development of synpolydactyly caused by expansion of HOXD13 polyalanine based on weighted gene co-expression network analysis., PMID:39472920
Methylation and transcriptome analyses construct a prognostic model and reveal the suppressor role of VMO1 in lung adenocarcinoma., PMID:39053673
Suppressing SENP1 inhibits esophageal squamous carcinoma cell growth via SIRT6 SUMOylation., PMID:38954215
Cell cycle specific, differentially tagged ribosomal proteins to measure phase specific transcriptomes from asynchronously cycling cells., PMID:38238470
Comprehensive Analysis of the Sorafenib-Associated Druggable Targets on Differential Gene Expression and ceRNA Network in Hepatocellular Carcinoma., PMID:37522567
Alterations in the spatiotemporal expression pattern of geminin during human epidermal morphogenesis., PMID:36945759
Introduction of a Geminin mScarlet Reporter into H2B-mTurq2 hiPSCs for Live-cell Imaging of Proliferation and Cell Cycling., PMID:36702081
High expression of GMNN predicts malignant progression and poor prognosis in ACC., PMID:36539849
Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study., PMID:36323878
Different expression of DNMT1, PCNA, MCM2, CDT1, EZH2, GMNN and EP300 genes in lymphomagenesis of low vs. high grade lymphoma., PMID:36257233
Adaptive exchange sustains cullin-RING ubiquitin ligase networks and proper licensing of DNA replication., PMID:36037385
Age and sex effects across the blood proteome after ionizing radiation exposure can bias biomarker screening and risk assessment., PMID:35487913
A Temporary Pause in the Replication Licensing Restriction Leads to Rereplication during Early Human Cell Differentiation., PMID:35326512
Novel Compound Heterozygous Variants in the CDC6 Gene in a Russian Patient with Meier-Gorlin Syndrome., PMID:35023948
Prognostic value of HPV 16/18 genotyping and geminin mRNA quantification in low-grade cervical squamous intraepithelial lesion., PMID:34874226
Gene expression signature as a surrogate marker of microvascular invasion on routine hepatocellular carcinoma biopsies., PMID:34624411
SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition., PMID:34599168
Live Imaging and Analysis of Cilia and Cell Cycle Dynamics with the Arl13bCerulean-Fucci2a Biosensor and Fucci Tools., PMID:34085231
Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree., PMID:34009124
High phospho-histone H3 expression uniquely predicts favorable survival among four markers of cellular proliferation in colorectal cancer., PMID:33631042
Cell kinetic markers in cutaneous squamous and basal cell carcinoma of the head and neck., PMID:32972865
Geminin is required for Hox gene regulation to pattern the developing limb., PMID:32450229
Targeting AXL and RAGE to prevent geminin overexpression-induced triple-negative breast cancer metastasis., PMID:31844158
Tissue-Specific DNA Replication Defects in Drosophila melanogaster Caused by a Meier-Gorlin Syndrome Mutation in Orc4., PMID:31818869
The DNA methylome in panic disorder: a case-control and longitudinal psychotherapy-epigenetic study., PMID:31754096
DNA Replication Inhibitor Geminin and Retinoic Acid Signaling Participate in Complex Interactions Associated With Pluripotency., PMID:31659113
The Cdk2-c-Myc-miR-571 Axis Regulates DNA Replication and Genomic Stability by Targeting Geminin., PMID:31431461
Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members., PMID:30824354
Gamma radiation induces locus specific changes to histone modification enrichment in zebrafish and Atlantic salmon., PMID:30759148
Overexpression of UHRF1 promoted the proliferation of vascular smooth cells via the regulation of Geminin protein levels., PMID:30710064
G9a-dependent histone methylation can be induced in G1 phase of cell cycle., PMID:30700744
MYCN is amplified during S phase, and c‑myb is involved in controlling MYCN expression and amplification in MYCN‑amplified neuroblastoma cell lines., PMID:30483774
Generation of Functional Hepatocytes from Human Adipose-Derived MYC+ KLF4+ GMNN+ Stem Cells Analyzed by Single-Cell RNA-Seq Profiling., PMID:30272835
Tracking neural crest cell cycle progression in vivo., PMID:29956448
Geminin ablation in vivo enhances tumorigenesis through increased genomic instability., PMID:29952003
Efficient Knock-in of a Point Mutation in Porcine Fibroblasts Using the CRISPR/Cas9-GMNN Fusion Gene., PMID:29899280
Controlling centriole numbers: Geminin family members as master regulators of centriole amplification and multiciliogenesis., PMID:29243212
Human cytomegalovirus miR-US5-1 inhibits viral replication by targeting Geminin mRNA., PMID:29116593
Geminin deletion in pre-meiotic DNA replication stage causes spermatogenesis defect and infertility., PMID:28690291
Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis., PMID:28436938
Detection of Significant Pneumococcal Meningitis Biomarkers by Ego Network., PMID:28247176
MCM5: a new actor in the link between DNA replication and Meier-Gorlin syndrome., PMID:28198391
Minichromosome maintenance protein 7 and geminin expression: Prognostic value in laryngeal squamous cell carcinoma in patients treated with radiotherapy and cetuximab., PMID:28032719
Validation of Synthetic CRISPR Reagents as a Tool for Arrayed Functional Genomic Screening., PMID:28030641
Gene regulatory networks in neural cell fate acquisition from genome-wide chromatin association of Geminin and Zic1., PMID:27881878
Geminin Is Essential for Pluripotent Cell Viability During Teratoma Formation, but Not for Differentiated Cell Viability During Teratoma Expansion., PMID:27821018
For research use only. Not for human or drug use.
