Catalog No.
YHB15401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe32-Val191
Predicted molecular weight
21.11 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75340
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Apoptosis-linked gene 2 protein homolog, PDCD6, Programmed cell death protein 6, ALG-2, ALG2
TDCPP disrupts ALG-2/ALIX-mediated ESCRT-III recruitment: Implications for lysosomal membrane repair and neurotoxicity., PMID:40425064
Calcium release from damaged lysosomes triggers stress granule formation for cell survival., PMID:39962896
PDCD6 regulates lactate metabolism to modulate LC3-associated phagocytosis and antibacterial defense., PMID:39578445
The role of PDCD6 in stemness maintenance of Glioblastoma., PMID:39561536
Association between PDCD6-VNTR polymorphism and urinary cancer susceptibility., PMID:38850471
Ca2+-sensor ALG-2 engages ESCRTs to enhance lysosomal membrane resilience to osmotic stress., PMID:38781205
AZGP1 deficiency promotes angiogenesis in prostate cancer., PMID:38659028
COPII with ALG2 and ESCRTs control lysosome-dependent microautophagy of ER exit sites., PMID:38593803
Multifaceted roles of PDCD6 both within and outside the cell., PMID:38436472
Surface Proteome of Extracellular Vesicles and Correlation Analysis Reveal Breast Cancer Biomarkers., PMID:38339272
Analysis of the Mouse Hepatic Peroxisome Proteome-Identification of Novel Protein Constituents Using a Semi-Quantitative SWATH-MS Approach., PMID:38247867
Identification of Key Genes Related to Immune Cells in Patients with COVID-19 Via Integrated Bioinformatics-Based Analysis., PMID:37222960
PDCD6 Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis through the AKT/GSK3β/β-catenin Pathway., PMID:37005078
Analysis of Dysferlin Direct Interactions with Putative Repair Proteins Links Apoptotic Signaling to Ca2+ Elevation via PDCD6 and FKBP8., PMID:36902136
Rare-variant association analysis reveals known and new age-related hearing loss genes., PMID:36788145
Identification of Important Factors Causing Developmental Arrest in Cloned Pig Embryos by Embryo Biopsy Combined with Microproteomics., PMID:36555617
Re-Analysis of Published Datasets in Search of Novel Urogenital Diseases Biomarkers., PMID:36177616
Electroacupuncture-Regulated miR-34a-3p/PDCD6 Axis Promotes Post-Spinal Cord Injury Recovery in Both In Vitro and In Vivo Settings., PMID:36132985
In vitro reconstitution of calcium-dependent recruitment of the human ESCRT machinery in lysosomal membrane repair., PMID:35994655
The Contribution of PDCD6 Polymorphisms to Oral Cancer Risk., PMID:35732318
Transcriptional expressions of hsa-mir-183 predicted target genes as independent indicators for prognosis in bladder urothelial carcinoma., PMID:35503998
Interplay Between Non-Coding RNAs and Programmed Cell Death Proteins., PMID:35402235
MAT2A facilitates PDCD6 methylation and promotes cell growth under glucose deprivation in cervical cancer., PMID:35396512
MicroRNA-183 accelerates the proliferation of hepatocyte during liver regeneration through targeting programmed cell death protein 6., PMID:35190998
ALG2 regulates type I interferon responses by inhibiting STING trafficking., PMID:34787301
ALG-2 and peflin regulate COPII targeting and secretion in response to calcium signaling., PMID:34762908
Proximity-Labeling Reveals Novel Host and Parasite Proteins at the Toxoplasma Parasitophorous Vacuole Membrane., PMID:34749525
Locally advanced undifferentiated sarcomatoid carcinoma of the right maxillary sinus with PDCD6-TERT fusion: A rare case report., PMID:34348839
Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis., PMID:33657879
The Novel ALG-2 Target Protein CDIP1 Promotes Cell Death by Interacting with ESCRT-I and VAPA/B., PMID:33503978
Natural compound catechol induces DNA damage, apoptosis, and G1 cell cycle arrest in breast cancer cells., PMID:33289235
Expression level of NEAT1 differentiates benign and malignant thyroid nodules by regulating NEAT1/miR‑9/PTEN and NEAT1/miR‑124/PDCD6 signalling., PMID:32901835
Amyloid beta regulates ER exit sites formation through O-GlcNAcylation triggered by disrupted calcium homeostasis., PMID:32885474
The Penta-EF-Hand ALG-2 Protein Interacts with the Cytosolic Domain of the SOCE Regulator SARAF and Interferes with Ubiquitination., PMID:32878247
PDCD6 cooperates with C-Raf to facilitate colorectal cancer progression via Raf/MEK/ERK activation., PMID:32746883
miR-9875 functions in antiviral immunity by targeting PDCD6 in mud crab (Scylla paramamosain)., PMID:32597292
[Pregnane X receptor promotes programmed cell death protein 4 expression in HepG2 cells]., PMID:32376574
ALG-2 couples T cell activation and apoptosis by regulating proteasome activity and influencing MCL1 stability., PMID:31919392
Structures and functions of penta-EF-hand calcium-binding proteins and their interacting partners: enigmatic relationships between ALG-2 and calpain-7., PMID:31814542
Highly expressed microRNA-124 inhibits migration and promotes apoptosis of esophageal cancer cells by degrading PDCD6., PMID:31128039
Annexin A7 is required for ESCRT III-mediated plasma membrane repair., PMID:31040365
High Sensitive Quantitative Binding Assays Using a Nanoluciferase-Fused Probe for Analysis of ALG-2-Interacting Proteins., PMID:30710293
Thermodynamic Characterization of the Ca2+-Dependent Interaction Between SOUL and ALG-2., PMID:30501057
Adaptor functions of the Ca2+-binding protein ALG-2 in protein transport from the endoplasmic reticulum., PMID:30259798
ALG-2 participates in recovery of cells after plasma membrane damage by electroporation and digitonin treatment., PMID:30240438
Molecular Characterisation and Functions of Fis1 and PDCD6 Genes from Echinococcus granulosus., PMID:30205566
Association of PDCD6 polymorphisms with the risk of cancer: Evidence from a meta-analysis., PMID:29872511
microRNA-124-3p inhibits the progression of congenital hypothyroidism via targeting programmed cell death protein 6., PMID:29805523
Ligation events influence ALG-2 dimerization., PMID:29758467
Up-regulation of miR-20a by HPV16 E6 exerts growth-promoting effects by targeting PDCD6 in cervical carcinoma cells., PMID:29710555
For research use only. Not for human or drug use.
