Catalog No.
YHB15301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile603-Ala846
Predicted molecular weight
53.61 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75339
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CILP-1, Cartilage intermediate-layer protein, Cartilage intermediate layer protein 1, CILP
Plasma exosome proteomics reveals upregulation of CILP-1 in concave side of paraspinal muscle in adolescent idiopathic scoliosis., PMID:40461962
Cartilage Intermediate Layer Protein-1 Promotes Extracellular Matrix Degeneration via Interacting With CD47., PMID:40122778
Exploring the Therapeutic Potential of MIR-140-3p in Osteoarthritis: Targeting CILP and Ferroptosis for Novel Treatment Strategies., PMID:40044625
Regulation of Clusterin in the Heart and Plasma of Mice After Transverse Aortic Constriction., PMID:39671261
Patient-responsive protein biomarkers for cartilage degeneration and repair identified in the infrapatellar fat pad., PMID:39635821
CILP-2 expression in the intervertebral discs of patients with lumbar radiculopathy., PMID:39506696
Antigen-specific T-cell frequency and phenotype mirrors disease activity in DRB1*04:04+ rheumatoid arthritis patients., PMID:39492692
Comparison of Antigen Retrieval Methods for Immunohistochemical Analysis of Cartilage Matrix Glycoproteins Using Cartilage Intermediate Layer Protein 2 (CILP-2) as an Example., PMID:39311368
Proteomics Analysis of Renal Cell Line Caki-2 with AFMID Overexpression and Potential Biomarker Discovery in Urine., PMID:39213636
Identification of HTRA1, DPT and MXRA5 as potential biomarkers associated with osteoarthritis progression and immune infiltration., PMID:39148085
CILP2 is a potential biomarker for the prediction and therapeutic target of peritoneal metastases in colorectal cancer., PMID:38816545
A murine model of hypertensive heart disease in older women., PMID:38799057
CILP-1 Is a Biomarker for Backward Failure and Right Ventricular Dysfunction in HFrEF., PMID:38132152
A novel biomarker of MMP-cleaved cartilage intermediate layer protein-1 is elevated in patients with rheumatoid arthritis, ankylosing spondylitis and osteoarthritis., PMID:38066013
Exosomes from M2c macrophages alleviate intervertebral disc degeneration by promoting synthesis of the extracellular matrix via MiR-124/CILP/TGF-β., PMID:38023721
Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis., PMID:37993439
CILP is a potential pan-cancer marker: combined silico study and in vitro analyses., PMID:37968343
Evaluation of Cartilage Integrity Following Administration of Oral and Intraarticular Nifedipine in a Murine Model of Osteoarthritis., PMID:37760884
Single-nuclear transcriptome profiling identifies persistent fibroblast activation in hypertrophic and failing human hearts of patients with longstanding disease., PMID:37648651
Synovial Fluid Proteomics From Serial Aspirations of ACL-Injured Knees Identifies Candidate Biomarkers., PMID:37191559
Quantitative proteomics identifies and validates urinary biomarkers of rhabdomyosarcoma in children., PMID:36918772
Genetic dissection of intercellular interactions in vivo by membrane-permeable protein., PMID:36574652
Expression of CILP-2 and DDR2 and ultrastructural changes in the articular cartilage of patients with knee osteoarthritis undergoing total knee arthroplasty: a pilot morphological study., PMID:36370214
Weighted Correlation Network Analysis of Cancer Stem Cell-Related Prognostic Biomarkers in Esophageal Squamous Cell Carcinoma., PMID:35899307
CILP, a Putative Gene Associated With Immune Infiltration in Breast Cancer Brain Metastases., PMID:35711946
Protein N-glycosylation aberrations and glycoproteomic network alterations in osteoarthritis and osteoarthritis with type 2 diabetes., PMID:35484284
The proteomic profile of the human myotendinous junction., PMID:35198892
Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor., PMID:35027402
Prognostic value of cartilage intermediate layer protein 1 in chronic heart failure., PMID:34939356
Matricellular Protein Cilp1 Promotes Myocardial Fibrosis in Response to Myocardial Infarction., PMID:34610755
MiR-330-5p inhibits intervertebral disk degeneration via targeting CILP., PMID:34233701
Cardiac Microvascular Endothelial Cells in Pressure Overload-Induced Heart Disease., PMID:33464950
Cartilage intermediate layer protein affects the progression of intervertebral disc degeneration by regulating the extracellular microenvironment (Review)., PMID:33416131
Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding., PMID:33325039
Human innate lymphoid cell precursors express CD48 that modulates ILC differentiation through 2B4 signaling., PMID:33219153
CILP1 as a biomarker for right ventricular maladaptation in pulmonary hypertension., PMID:33184116
High-Resolution Transcriptomic Profiling of the Heart During Chronic Stress Reveals Cellular Drivers of Cardiac Fibrosis and Hypertrophy., PMID:32795101
TGF-β Inhibitor CILP as a Novel Biomarker for Cardiac Fibrosis., PMID:32479564
Cardiac Fibrosis Is Associated With Decreased Circulating Levels of Full-Length CILP in Heart Failure., PMID:32478206
Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis., PMID:32423478
Conditional Immortalization of Lymphoid Progenitors via Tetracycline-Regulated LMO2 Expression., PMID:31760808
Transcriptional profiling of the murine intervertebral disc and age-associated changes in the nucleus pulposus., PMID:31597481
Association of Susceptibility Genes for Adolescent Idiopathic Scoliosis and Intervertebral Disc Degeneration With Adult Spinal Deformity., PMID:31365516
Association between changes in molecular biomarkers of cartilage matrix turnover and changes in knee articular cartilage: a longitudinal pilot study., PMID:31053993
Transcriptomic Response to 1,25-Dihydroxyvitamin D in Human Fibroblasts with or without a Functional Vitamin D Receptor (VDR): Novel Target Genes and Insights into VDR Basal Transcriptional Activity., PMID:30959822
CILP-2 is a novel secreted protein and associated with insulin resistance., PMID:30896018
Synovial fluid proteome changes in ACL injury-induced posttraumatic osteoarthritis: Proteomics analysis of porcine knee synovial fluid., PMID:30822327
Targeted proteomics of hip articular cartilage in OA and fracture patients., PMID:30307059
Association of CILP, COL9A2 and MMP3 Gene Polymorphisms with Lumbar Disc Degeneration in an Indian Population., PMID:30288688
Cartilage intermediate layer protein-1 alleviates pressure overload-induced cardiac fibrosis via interfering TGF-β1 signaling., PMID:29438665
For research use only. Not for human or drug use.
