Catalog No.
YHB12801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys1332-Leu1397
Predicted molecular weight
9.28 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75197
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Low-density lipoprotein receptor-related protein 5, LRP5, LRP-5, LRP7, LRP-7, Low-density lipoprotein receptor-related protein 7, LR3
Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions Using NanoBit/BRET., PMID:40497984
WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency., PMID:40492997
Natural Product Daidzin Inhibits Glioma Development via Suppressing the LRP5-Mediated GSK-3β/c-Myc Signaling Pathway., PMID:40476323
Gastrodin promotes osteogenic differentiation by stimulating the Wnt/β-catenin signaling pathway., PMID:40436074
WNT-induced association of Frizzled and LRP6 is not sufficient for the initiation of WNT/β-catenin signaling., PMID:40413190
Bridging Genomic Research Disparities in Osteoporosis GWAS: Insights for Diverse Populations., PMID:40411668
Ishophloroglucin A Isolated From Ishige okamurae Stimulates Osteoblast Differentiation Through Activation of the Bone Morphogenetic Protein and Wnt/β-Catenin Signaling Pathways in MC3T3-E1 Cells., PMID:40343669
Inhibition of Canonical Wnt Signaling in Renal Cell Carcinoma Bone Metastasis: An Immunohistochemical Analysis of DKK1 and LRP5 Expression., PMID:40337977
Gene Variants and Bisphosphonates Treatment in Pregnancy and Lactation-Associated Osteoporosis (PLO): A Retrospective Study of 22 Chinese Patients., PMID:40327138
Ref-1 redox activity modulates canonical Wnt signaling in endothelial cells., PMID:40305885
Genetic variants in the LRP5 gene associated with gain and loss of bone mineral density., PMID:40255261
Genetic Insights Into Early-Onset Type 2 Diabetes Mellitus: The Role of SOST and LRP5 Genotypic Variants in Young Indians., PMID:40196106
SOSTDC1 downregulation in CD4+ T cells confers protection against obesity-induced insulin resistance., PMID:40173040
Abortive PDCoV infection triggers Wnt/β-catenin pathway activation, enhancing intestinal stem cell self-renewal and promoting chicken resistance., PMID:40135895
Semaglutide promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells through activation of the Wnt/LRP5/β-catenin signaling pathway., PMID:40129942
SP7 transcription factor ameliorates bone defect healing in low-density lipoprotein receptor-related protein 5 (LRP5)-dependent osteoporosis mice., PMID:40082204
Bacteriocins from Lactic Acid Bacteria Could Modulate the Wnt Pathway: A Possible Therapeutic Candidate for the Management of Colorectal Cancer- An In silico Study., PMID:40077821
Blocking the Dkk1-LRP6 interaction prevents acute amyloid-β-driven cognitive impairment., PMID:40057150
Increased activation of the WNT pathway in brain tissue from patients with cortical dysplasia type IIb., PMID:40055364
HAS-CIRCpedia-5280 sponges miR-4712-5p inhibited colon cancer autophagyinduced by human beta-defensin-1., PMID:40050987
Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness., PMID:40038255
CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m6A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance., PMID:40036155
Wnt1 oversees microglial activation by the Wnt/LRP5/6 receptor signaling pathway during lipopolysaccharide-mediated toxicity., PMID:40025242
Underlying Disease in Atypical Retinopathy of Prematurity., PMID:40010420
LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity., PMID:40000740
LRP5 enhances glioma cell proliferation by modulating the MAPK/p53/cdc2 pathway., PMID:39991761
LRP4 and Agrin Are Modulated by Cartilage Degeneration and Involved in β-Catenin Signaling in Human Articular Chondrocytes., PMID:39940775
SNX5 facilitates the progression of gastric cancer by increasing the membrane localization of LRP5., PMID:39922976
Gene Variant Spectrum in Probands With Familial Exudative Vitreoretinopathy Using an Expanded Panel., PMID:39918476
Genotype-Phenotype Spectrum of eyeGENE Patients With Familial Exudative Vitreoretinopathy: Novel Variants in Norrin/β-Catenin Signaling Pathway Genes., PMID:39903177
The Relationship Between LRP-5 and LRP-6 Gene Mutations and Postmenopausal Type 2 Diabetes and Obesity., PMID:39902284
A bioinformatic approach to characterize the vitellogenin receptor and the low density lipoprotein receptor superfamily in the newt Cynops orientalis., PMID:39870874
LRP5 Down-Regulation Exacerbates Inflammation and Alveolar Bone Loss in Periodontitis by Inhibiting PI3K/c-FOS Signalling., PMID:39837316
Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation., PMID:39824186
Investigation of the Effects of Silymarin on Ovarian Ischemia Reperfusion via Nrf-2/HO-1/NQO1, Ki-67 and Wnt Signaling Pathways., PMID:39812109
DKK1 and Its Receptors in Esophageal Adenocarcinoma: A Promising Molecular Target., PMID:39795613
The effects of the Wnt/β-catenin signaling pathway on the in vitro differentiation of rat BMSCs into leydig cells., PMID:39775149
The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling., PMID:39745873
Incident Vertebral Fractures During Romosozumab Treatment in a Patient With a Pathogenic LRP5 Variant., PMID:39726666
Interplay between Netrin-1 and Norrin controls arteriovenous zonation of blood-retina barrier integrity., PMID:39693351
A phase I dose escalation study of the LRP5 antagonist BI 905681 in patients with advanced and metastatic solid tumors., PMID:39617535
A phase I dose-escalation study of LRP5/6 antagonist BI 905677 in patients with advanced solid tumors., PMID:39617530
Rescue of cochlear vascular pathology prevents sensory hair cell loss in Norrie disease., PMID:39585982
Zhuangyao Jianshen Wan ameliorates senile osteoporosis in SAMP6 mice through Modulation of the GCN5L1-mediated PI3K/Akt/wnt signaling pathway., PMID:39568803
Case report: exome sequencing identified mutations in the LRP5 and LGR4 genes in a case of osteoporosis with recurrent fractures and extraskeletal manifestations., PMID:39525853
Wnt signalosomes: What we know that we do not know., PMID:39520379
The RAAS system SNPs polymorphism is associated with essential hypertension risk in rural areas in northern China., PMID:39512695
Protective effects of electroacupuncture on senile osteoporosis in rats., PMID:39460675
Therapeutic targeting of Wnt antagonists by small molecules for treatment of osteoporosis., PMID:39447984
Clues into Wnt cell surface signalosomes and its biogenesis., PMID:39443209
For research use only. Not for human or drug use.
