Catalog No.
YHB10401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser771-Ala1012
Predicted molecular weight
29.06 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75146
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Huntingtin-interacting protein 12, HIP1-related protein, HIP12, Huntingtin-interacting protein 1-related protein, HIP1R, HIP-12, KIAA0655
Mendelian randomization analysis with the GEO database: Exploring the molecular mechanism underlying insulin therapy for Perioperative Neurocognitive Disorders., PMID:40513938
Regulatory Mechanisms and Therapeutic Targeting of PD-L1 Trafficking and Stability in Cancer Immunotherapy., PMID:40507229
Sla2 is a core interaction hub for clathrin light chain and the Pan1/End3/Sla1 complex., PMID:40347949
CLCa mediates a novel cross-talk between Wnt secretion and actin organization., PMID:40316417
Huntingtin-Interacting Protein 1-Related (HIP1R) Regulates Rheumatoid Arthritis Synovial Fibroblast Invasiveness., PMID:40214437
A single-particle analysis method for detecting membrane remodelling and curvature sensing., PMID:39324332
Machine learning and 4D-LFQ quantitative proteomic analysis explore the molecular mechanism of kidney stone formation., PMID:39114033
Detection of polyreactive immunoglobulin G facilitates diagnosis in children with autoimmune hepatitis., PMID:38976227
Clinical management of liver cyst infections: an international, modified Delphi-based clinical decision framework., PMID:38878785
Force redistribution in clathrin-mediated endocytosis revealed by coiled-coil force sensors., PMID:37831774
Commentary: Antibodies against multiple post-translationally modified proteins aid in diagnosis of autoimmune hepatitis and associate with complete biochemical response to treatment., PMID:37809342
DNA methylation and miR-92a-3p-mediated repression of HIP1R promotes pancreatic cancer progression by activating the PI3K/AKT pathway., PMID:36811277
Brain Proteome-Wide and Transcriptome-Wide Asso-ciation Studies, Bayesian Colocalization, and Mendelian Randomization Analyses Reveal Causal Genes of Parkinson's Disease., PMID:36511626
HIP1R and vimentin immunohistochemistry predict 1p/19q status in IDH-mutant glioma., PMID:35511748
Mechanistic insights into actin force generation during vesicle formation from cryo-electron tomography., PMID:35504288
The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery., PMID:35449600
Flurbiprofen inhibits cell proliferation in thyroid cancer through interrupting HIP1R-induced endocytosis of PTEN., PMID:35209947
Isolated THATCH domain of End4 is unable to bind F-actin independently in the fission yeast Schizosaccharomyces pombe., PMID:35024575
ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals., PMID:34821552
Cooperative regulation of endocytic vesicle transport by yeast Eps15-like protein Pan1p and epsins., PMID:34592316
Quantification of polyreactive immunoglobulin G facilitates the diagnosis of autoimmune hepatitis., PMID:34473365
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy., PMID:34388391
The Huntingtin-interacting protein SETD2/HYPB is an actin lysine methyltransferase., PMID:33008892
Huntingtin-interacting protein family members have a conserved pro-viral function from Caenorhabditis elegans to humans., PMID:32839311
HIP1R acts as a tumor suppressor in gastric cancer by promoting cancer cell apoptosis and inhibiting migration and invasion through modulating Akt., PMID:32548851
Identification of potential candidate genes and pathways in atrioventricular nodal reentry tachycardia by whole-exome sequencing., PMID:32508047
HIP1R Expression and Its Association with PD-1 Pathway Blockade Response in Refractory Advanced NonSmall Cell Lung Cancer: A Gene Set Enrichment Analysis., PMID:32403421
The black sheep of the family- whole-exome sequencing in family of lithium response discordant bipolar monozygotic twins., PMID:32305265
Checkpoints Under Traffic Control: From and to Organelles., PMID:32185721
Identification of Hub Genes in Pediatric Medulloblastoma by Multiple-Microarray Analysis., PMID:31820345
Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension., PMID:31672988
High-throughput assessment of the antibody profile in ovarian cancer ascitic fluids., PMID:31428516
The molecular mechanism study of insulin in promoting wound healing under high-glucose conditions., PMID:31081255
Endocytic Adaptor Protein HIP1R Controls Intracellular Trafficking of Epidermal Growth Factor Receptor in Neuronal Dendritic Development., PMID:30574069
HIP1R targets PD-L1 to lysosomal degradation to alter T cell-mediated cytotoxicity., PMID:30397328
FerriTag is a new genetically-encoded inducible tag for correlative light-electron microscopy., PMID:29973588
Proteomic analysis identifies NPTX1 and HIP1R as potential targets of histone deacetylase-3-mediated neurodegeneration., PMID:29486577
Gene expression meta-analysis in diffuse low-grade glioma and the corresponding histological subtypes., PMID:28924174
Huntingtin-Interacting Protein 1-Related Protein Plays a Critical Role in Dendritic Development and Excitatory Synapse Formation in Hippocampal Neurons., PMID:28663723
Endocytic proteins are partitioned at the edge of the clathrin lattice in mammalian cells., PMID:28346440
Murine Models of Gastric Corpus Preneoplasia., PMID:28174755
Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci., PMID:27504496
FOXP2-positive diffuse large B-cell lymphomas exhibit a poor response to R-CHOP therapy and distinct biological signatures., PMID:27224915
The microRNA-23b/-27b cluster suppresses prostate cancer metastasis via Huntingtin-interacting protein 1-related., PMID:26898757
Huntingtin-Interacting Protein-1 Is an Early-Stage Prognostic Biomarker of Lung Adenocarcinoma and Suppresses Metastasis via Akt-mediated Epithelial-Mesenchymal Transition., PMID:26595459
Low HIP1R mRNA and protein expression are associated with worse survival in diffuse large B-cell lymphoma patients treated with R-CHOP., PMID:26341140
The single nucleotide polymorphism Rs12817488 is associated with Parkinson's disease in the Chinese population., PMID:25818163
Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits., PMID:25122462
Actin scaffolding by clathrin heavy chain is required for skeletal muscle sarcomere organization., PMID:24798732
Spatiotemporal patterns of the Huntingtin-interacting protein 1-related gene in the mouse head., PMID:24712472
For research use only. Not for human or drug use.
