Catalog No.
YHB08301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn647-Arg835
Predicted molecular weight
23.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75093
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Multiple EGF-like domains protein 4, Slit-1, KIAA0813, Multiple epidermal growth factor-like domains protein 4, Slit homolog 1 protein, MEGF4, SLIL1, SLIT1
SLIT/ROBO Pathway and Prostate Cancer: Gene and Protein Expression and Their Prognostic Values., PMID:40508075
Oculomotor axons use external and autocrine Slit signals for fasciculation, navigation, branching, and connectivity in mouse embryos., PMID:40470230
A neuronal Slit1-dependent program rescues oligodendrocyte differentiation and myelination under chronic hypoxic conditions., PMID:40117292
Slit1 Promotes Hypertrophic Scar Formation Through the TGF-β Signaling Pathway., PMID:39768930
Multiple guidance mechanisms control axon growth to generate precise T-shaped bifurcation during dorsal funiculus development in the spinal cord., PMID:39159057
Desmoid tumors of rectus abdominis: A case report and literature review., PMID:39058871
Slit1 inhibits ovarian follicle development and female fertility in mice†., PMID:38943353
ALK-Rearranged Renal Cell Carcinoma: A Multi-Institutional Study of 9 Cases With Expanding the Morphologic and Molecular Genetic Spectrum., PMID:38852815
MethylRAD Sequencing Technology Reveals DNA Methylation Characteristics of Apostichopus japonicus of Different Ages., PMID:38003147
SLIT3-mediated fibroblast signaling: a promising target for antifibrotic therapies., PMID:37830982
The SLIT/ROBO Pathway in Liver Fibrosis and Cancer., PMID:37238655
Immune-related matrisomes are potential biomarkers to predict the prognosis and immune microenvironment of glioma patients., PMID:36560848
Molecular Docking and Molecular Dynamics Studies Reveal Secretory Proteins as Novel Targets of Temozolomide in Glioblastoma Multiforme., PMID:36364024
Copper Modulates Adult Neurogenesis in Brain Subventricular Zone., PMID:36077284
Micro RNA-640 Targeting SLIT1 Enhances Glioma Radiosensitivity by Restraining the Activation of Wnt/β-Catenin Signaling Pathway., PMID:35996510
Roundabout Guidance Receptor 1 Is an Emerging Prognostic Biomarker for Nasopharyngeal Carcinoma., PMID:35898392
Genetic Variants Associated with Supernormal Coronary Arteries., PMID:35793981
Discovery of Cancer-Specific and Independent Prognostic Gene Subsets of the Slit-Robo Family Using TCGA-PANCAN Datasets., PMID:34757814
[G-protein coupled receptor Smo positively regulates proliferation and migration of adult neural stem cells in vitro]., PMID:34755677
Expression of Slit and Robo during remodeling of corticospinal tract in cervical spinal cord in middle cerebral artery occlusion rats., PMID:34652618
Developmental genes controlling neural circuit formation are expressed in the early postnatal hypothalamus and cellular lining of the third ventricle., PMID:34423876
Isolated congenital diaphragm hernia associated with homozygous SLIT3 gene variant in dizygous twins., PMID:33933663
Sex-Specific Role for SLIT1 in Regulating Stress Susceptibility., PMID:33896623
Analysis of Differentially Expressed Genes in the Dentate Gyrus and Anterior Cingulate Cortex in a Mouse Model of Depression., PMID:33628784
Long-term sublingual immunotherapy provides better effects for patients with Japanese cedar pollinosis., PMID:33526319
Slit/Robo signaling regulates Leydig cell steroidogenesis., PMID:33478524
Knockdown of slit signaling during limb development leads to a reduction in humerus length., PMID:33347679
Transcriptome and methylome analysis reveals three cellular origins of pituitary tumors., PMID:33168897
Transcriptional landscape of the embryonic chicken Müllerian duct., PMID:33008304
High glucose alters the DNA methylation pattern of neurodevelopment associated genes in human neural progenitor cells in vitro., PMID:32973238
Slit1 Protein Regulates SVZ-Derived Precursor Mobilization in the Adult Demyelinated CNS., PMID:32670024
Expression patterns of SLIT/ROBO mRNAs reveal a characteristic feature in the entorhinal-hippocampal area of macaque monkeys., PMID:32460877
Lentivirally administered glial cell line-derived neurotrophic factor promotes post-ischemic neurological recovery, brain remodeling and contralesional pyramidal tract plasticity by regulating axonal growth inhibitors and guidance proteins., PMID:32454038
Transplantation of sh-miR-199a-5p-Modified Olfactory Ensheathing Cells Promotes the Functional Recovery in Rats with Contusive Spinal Cord Injury., PMID:32252553
Lhx2/9 and Etv1 Transcription Factors have Complementary roles in Regulating the Expression of Guidance Genes slit1 and sema3a., PMID:32200077
An Overview of Extrinsic and Intrinsic Mechanisms Involved in Astrocyte Development in the Central Nervous System., PMID:31847709
Expression of Developmentally Important Axon Guidance Cues in the Adult Optic Chiasm., PMID:31731293
Dynamic expression of Slit1-3 and Robo1-2 in the mouse peripheral nervous system after injury., PMID:31719262
Cell type-specific transcriptome analysis unveils secreted signaling molecule genes expressed in apical epithelial cap during appendage regeneration., PMID:31713234
Slit/Robo signals prevent spinal motor neuron emigration by organizing the spinal cord basement membrane., PMID:31356769
Toxicogenomic analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation system., PMID:31326446
Targeting the SLIT/ROBO pathway in tumor progression: molecular mechanisms and therapeutic perspectives., PMID:31217826
Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia., PMID:31186493
Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons., PMID:31070778
The Expression of Key Guidance Genes at a Forebrain Axon Turning Point Is Maintained by Distinct Fgfr Isoforms but a Common Downstream Signal Transduction Mechanism., PMID:30993182
The Expression of the SLIT-ROBO Family in Adult Patients with Acute Myeloid Leukemia., PMID:30820596
Slit/Robo Signaling Pathway in Cancer; a New Stand Point for Cancer Treatment., PMID:30610466
New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration., PMID:30547091
Fibroblast growth factor receptor 1 signaling transcriptionally regulates the axon guidance cue slit1., PMID:29705951
Role of miR-452-5p in the tumorigenesis of prostate cancer: A study based on the Cancer Genome Atl(TCGA), Gene Expression Omnibus (GEO), and bioinformatics analysis., PMID:29559248
For research use only. Not for human or drug use.
