Catalog No.
YHB06101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val472-Cys752
Predicted molecular weight
33.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75027
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ABC transporter 7 protein, ABC7, ATP-binding cassette sub-family B member 7, mitochondrial, ATP-binding cassette transporter 7, ABCB7
Conformational equilibrium of an ABC transporter analyzed by luminescence resonance energy transfer., PMID:39973007
Iron overload in acquired sideroblastic anemias and MDS: pathophysiology and role of chelation and luspatercept., PMID:39644054
Expression of ABC transporters in the Drosophila testis stem cell niche: Comparison of two approaches., PMID:39638273
ATM1, an essential conserved transporter in Apicomplexa, bridges mitochondrial and cytosolic [Fe-S] biogenesis., PMID:39348385
The Toxoplasma gondii mitochondrial transporter ABCB7L is essential for the biogenesis of cytosolic and nuclear iron-sulfur cluster proteins and cytosolic translation., PMID:39207139
HDAC1 and FOXK1 mediate EGFR-TKI resistance of non-small cell lung cancer through miR-33a silencing., PMID:39198847
ATP-Binding Cassette Transporter of Clinical Significance: Sideroblastic Anemia., PMID:38929857
The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts., PMID:38759096
Requirements for the biogenesis of [2Fe-2S] proteins in the human and yeast cytosol., PMID:38743629
Mitochondria function in cytoplasmic FeS protein biogenesis., PMID:38641180
Structural bioinformatics studies of six human ABC transporters and their AlphaFold2-predicted water-soluble QTY variants., PMID:38577032
SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia., PMID:38517966
The role of ATP binding cassette (ABC) transporters in breast cancer: Evaluating prognosis, predicting immunity, and guiding treatment., PMID:37905302
Knockdown of ABCB7 inhibits esophageal cancer progression by inhibiting the TGF-β/Smad signaling., PMID:37142077
Myelodysplastic syndromes with ring sideroblasts., PMID:36794650
Exploring the mechanistic link between SF3B1 mutation and ring sideroblast formation in myelodysplastic syndrome., PMID:36028755
Structures of Atm1 provide insight into [2Fe-2S] cluster export from mitochondria., PMID:35896548
Quantitative Assessment of the Impact of Crohn's Disease on Protein Abundance of Human Intestinal Drug-Metabolising Enzymes and Transporters., PMID:35872023
Cryo-EM structure of AMP-PNP-bound human mitochondrial ATP-binding cassette transporter ABCB7., PMID:35041979
Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle., PMID:34936443
Coordinated missplicing of TMEM14C and ABCB7 causes ring sideroblast formation in SF3B1-mutant myelodysplastic syndrome., PMID:34861039
The mitochondrial iron transporter ABCB7 is required for B cell development, proliferation, and class switch recombination in mice., PMID:34762046
Glutathione-coordinated metal complexes as substrates for cellular transporters., PMID:33770183
Expression, purification and microscopic characterization of human ATP-binding cassette sub-family B member 7 protein., PMID:33689857
Evolution of the human mitochondrial ABCB7 [2Fe-2S](GS)4 cluster exporter and the molecular mechanism of an E433K disease-causing mutation., PMID:33157103
Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells., PMID:32814794
Enhancing mitochondrial function in vivo rescues MDS-like anemia induced by pRb deficiency., PMID:32629063
Hereditary Ataxia: A Focus on Heme Metabolism and Fe-S Cluster Biogenesis., PMID:32466579
Defining the mechanism of the mitochondrial Atm1p [2Fe-2S] cluster exporter., PMID:32337520
Molecular evidence of impaired iron metabolism and its association with Parkinson's disease progression., PMID:32206507
ABCB7 simultaneously regulates apoptotic and non-apoptotic cell death by modulating mitochondrial ROS and HIF1α-driven NFκB signaling., PMID:31772327
The Clinical and Molecular Spectrum of GM1 Gangliosidosis., PMID:31761138
Chronic Pressure Overload Results in Deficiency of Mitochondrial Membrane Transporter ABCB7 Which Contributes to Iron Overload, Mitochondrial Dysfunction, Metabolic Shift and Worsens Cardiac Function., PMID:31511561
Comparative analysis of growth performance and liver transcriptome response of juvenile Ancherythroculter nigrocauda fed diets with different protein levels., PMID:31200228
The indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways., PMID:30923992
The ABCB7-Like Transporter PexA in Rhodobacter capsulatus Is Involved in the Translocation of Reactive Sulfur Species., PMID:30918498
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis., PMID:30765471
Optimized protocols for studying the NLRP3 inflammasome and assessment of potential targets of CP-453,773 in undifferentiated THP1 cells., PMID:30735689
[Splicing factor mutations in myelodysplastic syndromes]., PMID:29877248
Impact of TET2 deficiency on iron metabolism in erythroblasts., PMID:28167288
Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts., PMID:27604819
Danio rerio ABC transporter genes abcb3 and abcb7 play a protecting role against metal contamination., PMID:27734548
Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes., PMID:27211273
What is the acceptable hemolysis index for the measurements of plasma potassium, LDH and AST?, PMID:27159801
LmABCB3, an atypical mitochondrial ABC transporter essential for Leishmania major virulence, acts in heme and cytosolic iron/sulfur clusters biogenesis., PMID:26728034
Structures and functions of mitochondrial ABC transporters., PMID:26517908
Whole-genome sequencing identifies a novel ABCB7 gene mutation for X-linked congenital cerebellar ataxia in a large family of Mongolian ancestry., PMID:26242992
The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron-sulfur proteins., PMID:26099175
Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability., PMID:25583461
Glutathione-coordinated [2Fe-2S] cluster: a viable physiological substrate for mitochondrial ABCB7 transport., PMID:25556595
For research use only. Not for human or drug use.
