Catalog No.
YHA97301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn508-Ala800
Predicted molecular weight
35.94 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60674
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Janus kinase 2, JAK2, Tyrosine-protein kinase JAK2, JAK-2
Ginsenoside Rg5 alleviates hypoxia-induced myocardial apoptosis by targeting STAT3 to promote Tyr705 phosphorylation., PMID:40514732
EIF3B Promotes KRAS Gene Mutation-Driven Colon Adenocarcinoma Progression Through the TBK1 and PI3K/AKT Signaling Pathways., PMID:40503732
MicroRNA-6084 orchestrates angiogenesis and liver metastasis in colorectal cancer via extracellular vesicles., PMID:40493409
Network pharmacology and molecular docking-based characterization of the mechanisms through which Astragali Radix-Atractylodes macrocephala Koidz herb pair can treat membranous nephropathy., PMID:40489804
Targeting the JAK2-STAT3-UCHL3-ENO1 axis suppresses glycolysis and enhances the sensitivity to 5-FU chemotherapy in TP53-mutant colorectal cancer., PMID:40487654
M1 Macrophage is a Novel Potential Trigger for Endothelial Senescence: Role of Exosomal miR-155 Targeting SOCS1 Signal., PMID:40486266
IκBζ promotes acute myocardial infarction via endonuclear STAT3 deactivation., PMID:40482874
Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusion: report of two cases with different clinical presentation., PMID:40474715
A rare CALR exon 9 mutation p.E379Vfs*53 in AYA generation exhibits gain-of-function nature and can induce essential thrombocythemia; a case report., PMID:40474352
Fibrinogen regulates microglial function through the JAK2/STAT3 signaling pathway., PMID:40472614
Role of USP10/METTL3/CXCR4 Axis in Immunotherapy of Castration-Resistant Prostate Cancer., PMID:40471642
RNF213 Knockdown and Inflammation Promote Angiogenesis and Phenotype Switching by JAK2/STAT3 Pathway in Moyamoya Disease., PMID:40467938
Primary myelofibrosis with concurrent MPL and atypical JAK2 mutations., PMID:40467885
The Effect of Thymic Stromal Lymphopoietin on Reflux Esophagitis., PMID:40464554
Wenqing Yin Attenuates the Allergic Contact Dermatitis Response by Inhibiting the JAK2/STAT1 and MAPK Signaling Pathways., PMID:40463860
Probiotics ameliorate H. pylori-associated gastric β-catenin and COX-2 carcinogenesis signaling by regulating miR-185., PMID:40462044
A tryptophol-containing emulgel ameliorates imiquimod-induced mice psoriasis., PMID:40461662
Discovery of a Proteolysis-Targeting Chimera Degrader of JAK2 as a Potential Therapeutic Agent for JAK2-Mediated Myeloproliferative Neoplasms., PMID:40460439
Effects of the nuclear localization sequence and C-terminus of Parathyroid hormone-related protein on the growth Hormone-IGF-1 axis., PMID:40451546
The AhR regulates IFN-induced immune checkpoints in lung cancer cells through HNRNPH1, an RNA-binding protein, and INCR1, a novel long non-coding RNA., PMID:40449595
SPI1 affects Aβ1-42-induced microglia-mediated neuroinflammation by transcriptionally regulating FOSL2 expression., PMID:40449341
BNC1 inhibits the development and progression of gastric cancer by regulating the CCL20/JAK-STAT axis., PMID:40444282
MAP2K2 Knockdown Suppresses Phenotypic Transformation of Vascular Smooth Muscle Cells in Aortic Dissection by Inactivating the JAK/STAT Signaling Pathway., PMID:40437968
Therapeutic role of Crateva religiosa in diabetic nephropathy: Insights into key signaling pathways., PMID:40435181
Pharmacophore Modeling of Janus Kinase Inhibitors: Tools for Drug Discovery and Exposition Prediction., PMID:40430355
CRISPR/Cas9-Based Modeling of JAK2 V617F Mutation in K562 Cells Reveals Enhanced Proliferation and Sensitivity to Therapeutic Agents., PMID:40429745
M2 macrophages activate the IL-10/JAK2/STAT3 pathway to induce pathological microangiogenesis in the nucleus pulposus exacerbating intervertebral disc degeneration., PMID:40426248
Electroacupuncture stimulation inhibited astrogliosis and microglia polarisation to alleviate spinal cord injury via Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway., PMID:40421823
Acetylcholine from tuft cells promotes M2 macrophages polarization in Hirschsprung-associated enterocolitis., PMID:40416975
[The effects of resveratrol on osteosarcoma cells: Regulation of the interaction between JAK2/STAT3 signaling pathway and tumor immune microenvironment]., PMID:40415621
CD19+IL-10+ regulatory B cells induced by IL-12p35 regulates functional T-cell subsets in patients with immune thrombocytopenia., PMID:40415408
Glycyrrhizic Acid Ameliorates Sepsis-Induced Acute Lung Injury Through Suppression of Endoplasmic Reticulum Stress., PMID:40415359
Efficacy of JAK1/2 inhibition in murine myeloproliferative neoplasms is not mediated by targeting oncogenic signaling., PMID:40413183
Integrated analyses reveal CXCL11 as an inhibitor in ovarian cancer and its facilitation of an M1 macrophage switch via the JAK2/STAT1 pathway., PMID:40409100
Momelotinib - a tale of trials, tribulations, transfusion independence, and triumph., PMID:40405506
VSIG4 Promotes Tumour-Associated Macrophage M2 Polarization and Immune Escape in Colorectal Cancer via Fatty Acid Oxidation Pathway., PMID:40405491
Screening of Leptin-LepR modulators using molecular docking and binding assay., PMID:40400663
Malvidin Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Modulating JAK2/STAT3 Signaling to Inhibit Macrophage M1 Polarization and Oxidative Stress., PMID:40397040
IL-33 alleviates corneal nerve damage in herpes simplex keratitis., PMID:40394801
Recent advances and future perspectives in small molecule JAK2 inhibitors., PMID:40392133
JAK1/2 Inhibitors Alleviate the Damage of Intercellular Adhesion by Reducing Endoplasmic Reticulum Stress-Induced Apoptosis in Pemphigus Vulgaris., PMID:40392073
Sulforaphane Promotes the Skeletal Muscle Postinjury Regeneration by Up-Regulating the Transcription of Prl2c2 through JAK2/STAT3 Signaling., PMID:40391687
Network Pharmacology Study on the Mechanisms of Panax Notoginseng in the Treatment of Diabetic Retinopathy and Cataract., PMID:40391004
Cytoplasmic HMGB1 promotes the activation of JAK2-STAT3 signaling and PD-L1 expression in breast cancer., PMID:40389855
Lactate induces oxidative phosphorylation in osteoblasts via Gpr81-Stat3 signaling., PMID:40389045
POSTN Silencing Ameliorates LL37-Induced Rosacea and Inhibits the JAK2/STAT3 and NF-κB Pathways., PMID:40387439
Comprehensive analysis of protective effects of Loranthus tanakae Franch. and Sav. on ovalbumin-induced atopic dermatitis in mice and TNF-α/INF-γ-stimulated HaCaT cells., PMID:40385597
Modulating the Immunosuppressive Tumor Microenvironment and Inhibiting Growth in Mutp53-Driven CRPC via STAT3 Pathway Blockade., PMID:40384867
Dimethyl fumarate ameliorated pyroptosis in contrast-induced acute renal injury by regulating endoplasmic reticulum stress and JAK2-STAT3 pathway., PMID:40384344
Experimental Autoimmune Neuritis Nerve Demyelination Is Attenuated by Blocking JAK2/STAT3 Signaling Pathway in Rats., PMID:40383991
For research use only. Not for human or drug use.
