Catalog No.
YHA94801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys26-Asp184
Predicted molecular weight
20.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60565
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cysteine knot superfamily 1, BMP antagonist 1, CKTSF1B1, Down-regulated in Mos-transformed cells protein, Increased in high glucose protein 2, IHG-2, DRM, GREM1, Gremlin-1, Cell proliferation-inducing gene 2 protein, DAN domain family member 2, DAND2
Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling., PMID:40467544
Associations of plasma protein levels with risk of colorectal cancer: a proteome-wide Mendelian randomization study., PMID:40462010
Changes in Gene Transcription in Cumulus Cells from Women of Advanced Maternal Age under the Influence of Extracellular Vesicles from Follicular Fluid of Young Donors., PMID:40448879
Thymoquinone enhances efficacy of cervical Cancer therapeutic vaccines via modulating CD8+ T cells., PMID:40316484
GREM1 deficiency induced bone marrow adipose niche promotes B-cell acute lymphoblastic leukemia disease progression., PMID:40285538
The Role of GREMLIN1, a Bone Morphogenetic Protein Antagonist, in Cancer Stem Cell Regulation., PMID:40277903
New insights into Gremlin-1: A tumour microenvironment landscape re-engineer and potential therapeutic target., PMID:40250712
Pan-cancer multi-omics analysis to identify the potential pro-oncogenic properties of GREM1 as a promising targets for cancer prognosis and therapeutics., PMID:40231657
Identification and analysis of extracellular matrix and epithelial-mesenchymal transition-related genes in idiopathic pulmonary fibrosis by bioinformatics analysis and experimental validation., PMID:40187620
Depletion of marrow adipo-CAR cells in mice enhances bone formation by activating bone morphogenetic protein receptor (BMPR) in pre-osteoblasts., PMID:40156928
A Gremlin 1-expressing splenic niche cell population restrains chronic myeloid leukemia by antagonizing the BMP pathway., PMID:40097655
Identifying Key Genetic Factors Influencing Reproductive Performance in Dairy and Meat Sheep Breeds of the Mediterranean Region., PMID:40095270
Ex.50.T aptamer impairs tumor-stroma cross-talk in breast cancer by targeting gremlin-1., PMID:40069570
A comprehensive prognostic and immunological implications of Gremlin 1 in lung adenocarcinoma., PMID:40066442
Endothelial PD-1 Regulates Vascular Homeostasis and Oligodendrogenesis during Brain Development., PMID:40013943
Targeted delivery of Grem1 and IL-10 separately by mesenchymal stem cells effectively mitigates SETD2-deficient inflammatory bowel disease., PMID:39990215
Predictive roles of Asprosin and Gremlin-1 expression in Egyptian pediatric patients with type 1 diabetes., PMID:39979315
Single-cell profiling of penta- and tetradactyl mouse limb buds identifies mesenchymal progenitors controlling digit numbers and identities., PMID:39890843
A proteogenomic analysis of the adiposity colorectal cancer relationship identifies GREM1 as a probable mediator., PMID:39846783
Huc-MSC-derived exosomes alleviates alcohol-induced osteonecrosis of the femoral head through targeting the miR-25-3p/GREM1 axis., PMID:39826815
Conditional Deletion of Gremlin-1 in Cathepsin K-expressing Mature Osteoclasts Altered the Skeletal Response to Calcium Depletion in Sex-Dependent Manner., PMID:39789342
Unraveling the interplay between cardiovascular diseases and alcohol use disorder: A bioinformatics and network-based exploration of shared molecular pathways and key biomarkers validation via western blot analysis., PMID:39778286
Extravillous trophoblasts reverse the decidualization induced increase in matrix production by secreting TGFβ antagonists Emilin-1 and Gremlin-1., PMID:39756583
Changes in retinal microvasculature and serum Gremlin-1 levels in acromegaly: A case-control study., PMID:39592020
Filamin B knockdown impairs differentiation and function in mouse pre-osteoblasts via aberrant transcription and alternative splicing., PMID:39498024
Unveiling the significance of Gremlin-1 as a novel biomarker for enhanced severity prediction in COVID-19 patients., PMID:39465816
GREM1 may be a biological indicator and potential target of bladder cancer., PMID:39375386
Evaluation of Gremlin-1 as a therapeutic target in metabolic dysfunction-associated steatohepatitis., PMID:39361025
Gremlin1: a BMP antagonist with therapeutic potential in Oncology., PMID:39347850
Dissecting SOX9 dynamics reveals its differential regulation in osteoarthritis., PMID:39344191
Quantification of Gremlin 1 throughout the tumor stroma using whole slide imaging and its clinicopathological significance in gastric cancer., PMID:39225725
GREM1 Negatively Regulates Osteo-/Dentinogenic Differentiation of Dental Pulp Stem Cells via Association with YWHAH., PMID:39221981
Bone morphogenic protein-4 availability in the cardiac microenvironment controls inflammation and fibrosis in autoimmune myocarditis., PMID:39196111
miR-542-5p targets GREM1 to affect the progression of renal fibrosis., PMID:39180371
Blocking Gremlin1 inhibits M1 macrophage polarization through Notch1/Hes1 signaling pathway in apical periodontitis., PMID:39134472
Expression of Osteopontin and Gremlin 1 Proteins in Cardiomyocytes in Ischemic Heart Failure., PMID:39125809
Gastrodin Ameliorates the Inflammation, Oxidative Stress, and Extracellular Matrix Degradation of IL-1β-Mediated Fibroblast-Like Synoviocytes via Suppressing the Gremlin-1/NF-κB Pathway., PMID:39054715
miR-455/GREM1 axis promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing M2 macrophage polarization., PMID:38970064
Pseudogenization of NK3 homeobox 2 (Nkx3.2) in monotremes provides insight into unique gastric anatomy and physiology., PMID:38955222
Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration., PMID:38865240
Increased Gremlin1 Expression in Pancreatic Ductal Adenocarcinoma Promotes a Fibrogenic Stromal Microenvironment., PMID:38829570
Non-TGFβ profibrotic signaling in ulcerative colitis after in vivo experimental intestinal injury in humans., PMID:38713614
The pathogenic mechanism of syndactyly type V identified in a Hoxd13Q50R knock-in mice., PMID:38561387
Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis., PMID:38524634
Transcriptomic Analysis Reveals Intrinsic Abnormalities in Endometrial Polyps., PMID:38473810
Analysis of the Association between Copy Number Variation and Ventricular Fibrillation in ST-Elevation Acute Myocardial Infarction., PMID:38473795
SHH regulates penile morphology and smooth muscle through a mechanism involving BMP4 and GREM1., PMID:38451321
BMP4 and GREM1 are targets of SHH signaling and downstream regulators of collagen in the penis., PMID:38451311
Exploring the role of the WNT5A rs566926 polymorphism and its interactions in non-syndromic orofacial cleft: a multicenter study in Brazil., PMID:38359266
PLAU and GREM1 are prognostic biomarkers for predicting immune response in lung adenocarcinoma., PMID:38306567
For research use only. Not for human or drug use.
