Catalog No.
YHA92501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys3511-Ser3623
Predicted molecular weight
14.57 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60494
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cubilin, 460 kDa receptor, Intrinsic factor-vitamin B12 receptor, IFCR, Intestinal intrinsic factor receptor, Intrinsic factor-cobalamin receptor, CUBN
Tubular proteinuria due to hereditary endocytic receptor disorder of the proximal tubule: Dent disease and chronic benign proteinuria., PMID:40163114
Chronic Benign Tubular Albuminuria From Compound Heterozygous Variants in CUBN: A Case Report., PMID:39911140
Association of iron homeostasis-related gene polymorphisms with pregnancy and neonatal outcomes in patients with gestational diabetes mellitus., PMID:39666683
HDL Cholesterol-Associated Shifts in the Expression of Preselected Genes Reveal both Pro-Atherogenic and Atheroprotective Effects of HDL in Coronary Artery Disease., PMID:39614436
New findings on the genetic basis of feathered legs in chickens: association of CUBN gene mutations with feathered-leg phenotype., PMID:39187978
Identification of CUBN variants in triplets with a 20-year history of proteinuria., PMID:39102129
Effects of High-Dose Vitamin D Supplementation on Placental Vitamin D Metabolism and Neonatal Vitamin D Status., PMID:38999892
Controversy between biopsy and risk in children with proteinuria: is there a paradigm war?, PMID:38992620
Cytoplasmic Lipid Droplets Predict Worse Prognosis in Diffuse Large B-Cell Lymphoma: Next-Generation Sequencing Deciphering Lipogenic Genes., PMID:38979928
Research on the Mechanism of Metaldehyde on Pomacea canaliculata., PMID:38869049
Systematic Review of Genetic Modifiers Associated with the Development and/or Progression of Nephropathy in Patients with Sickle Cell Disease., PMID:38791464
Low Cubilin/Myeloperoxidase ratio as a promising biomarker for prognosis of high-grade T1 bladder cancer., PMID:38530585
Evaluation of serum and urine biomarkers for severe COVID-19., PMID:38510452
Identification of novel pathogenic variants of CUBN in patients with isolated proteinuria., PMID:38488435
Development of a Highly Differentiated Human Primary Proximal Tubule MPS Model (aProximate MPS Flow)., PMID:38275575
Expression of the cobalamin transporters cubam and MRP1 in the canine ileum-Upregulation in chronic inflammatory enteropathy., PMID:38206981
Polymorphisms in LRP2 and CUBN genes and their association with serum vitamin D levels and sleep apnea., PMID:38008818
Identification of the potential association between SARS-CoV-2 infection and acute kidney injury based on the shared gene signatures and regulatory network., PMID:37789254
Receptor-associated protein impairs ligand binding to megalin and megalin-dependent endocytic flux in proximal tubule cells., PMID:37534387
Molecular mimicry and COVID-19: Potential implications for global fertility., PMID:37520465
Four missense genetic variants in CUBN are associated with higher levels of eGFR in non-diabetes but not in diabetes mellitus or its subtypes: A genetic association study in Europeans., PMID:36926036
Podocytopathy and Glomerular Basement Membrane Anomalies in Two Patients With Cubilin Gene Mutations., PMID:36913226
Biochemical network analysis of protein-protein interactions to follow-up T1 bladder cancer patients., PMID:36870676
Vitamin D-Related Genes and Thyroid Cancer-A Systematic Review., PMID:36362448
Clinical relevance of vitamin B12 level and vitamin B12 metabolic gene variation in pulmonary tuberculosis., PMID:36275653
Novel pathogenic variants in CUBN uncouple proteinuria from renal function., PMID:36266725
Clinical and genetic characterization of children with cubilin variants., PMID:36112210
Identification of recurrent variants implicated in disease in bicuspid aortic valve patients through whole-exome sequencing., PMID:36071494
Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation Strategies., PMID:35807880
Vitamin B-related Gene Polymorphisms and Cardiovascular Disease., PMID:35346016
Cubilin, the intrinsic factor-vitamin B12 receptor., PMID:35337634
Genomic analyses reveal SCN7A is associated with the prognosis of esophageal squamous cell carcinoma., PMID:34993672
Dynamic urine proteome changes in a rat model of simvastatin-induced skeletal muscle injury., PMID:34990819
CUBN gene mutations may cause focal segmental glomerulosclerosis (FSGS) in children., PMID:34979989
Cubilin-, megalin-, and Dab2-dependent transcription revealed by CRISPR/Cas9 knockout in kidney proximal tubule cells., PMID:34747197
Endocytosis mediated by an atypical CUBAM complex modulates slit diaphragm dynamics in nephrocytes., PMID:34738617
Clinical and genetic characterization of a cohort of proteinuric patients with biallelic CUBN variants., PMID:34610128
Novel somatic variants involved in biochemical activity of pure growth hormone-secreting pituitary adenoma without GNAS variant., PMID:34400688
Genes and Pathways Affecting Sheep Productivity Traits: Genetic Parameters, Genome-Wide Association Mapping, and Pathway Enrichment Analysis., PMID:34394196
CircSPIDR acts as a tumour suppressor in cervical adenocarcinoma by sponging miR-431-5p and regulating SORCS1 and CUBN expression., PMID:34326275
A 17-Month-old Boy With Pancytopenia Caused by a Rare Genetic Defect of Vitamin B12 Malabsorption., PMID:34054045
Adipose triglyceride lipase protects renal cell endocytosis in a Drosophila dietary model of chronic kidney disease., PMID:33945525
Shotgun Proteomics of Isolated Urinary Extracellular Vesicles for Investigating Respiratory Impedance in Healthy Preschoolers., PMID:33652646
Clinical and molecular characteristics of imerslund-gräsbeck syndrome: First report of a novel Frameshift variant in Exon 11 of AMN gene., PMID:33491342
A vector whitefly endocytic receptor facilitates the entry of begomoviruses into its midgut cells via binding to virion capsid proteins., PMID:33270808
HDL cholesterol is associated with PBMC expression of genes involved in HDL metabolism and atherogenesis., PMID:33269026
Bioinformatics for The Prognostic Value and Function of Cubilin (CUBN) in Colorectal Cancer., PMID:33235183
Novel CUBN Mutation in a Young Child With Megaloblastic Anemia., PMID:33031161
A study of associations between CUBN, HNF1A, and LIPC gene polymorphisms and coronary artery disease., PMID:33004870
Tuberculosis risk is associated with genetic polymorphisms in the LRP2, CUBN, and VDR genes., PMID:32803705
For research use only. Not for human or drug use.
