Catalog No.
YHA88001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser607-Lys960
Predicted molecular weight
44.50 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>80% as determined by SDS-PAGE.
Accession
O60313
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA0567, OPA1, Optic atrophy protein 1, Dynamin-like 120 kDa protein, mitochondrial
Alleviation of metabolic dysfunction-associated steatotic liver disease by silymarin is associated with maintaining mitochondrial homeostasis via regulation of optic atrophy 1., PMID:40505414
Roles of Mitochondrial Fusion and Division in Harmine Derivative H-2-168-Induced Neurotoxicity., PMID:40496271
Machine Learning Applied to Visual Fields of Dominant Optic Atrophy Patients., PMID:40492996
Umbelliferone attenuates diabetic sarcopenia by modulating mitochondrial quality and the ubiquitin-proteasome system., PMID:40483791
mTOR inhibition triggers mitochondrial fragmentation in cardiomyocytes through proteosome-dependent prohibitin degradation and OPA-1 cleavage., PMID:40450326
Melatonin modulates mitochondrial function and inhibits atherosclerosis progression through NRF2 activation and OPA1 inhibition., PMID:40449269
The Gut Microbial Metabolite Butyrate Alleviates IL-1β-Induced Mitochondrial Dysfunction and Oxidative Stress in Pancreatic Islets., PMID:40444526
Hyperbaric oxygen therapy attenuates carbon monoxide-induced lung injury by restoring mitochondrial dynamics and suppressing Pink1/Parkin-mediated mitophagy., PMID:40441279
Lysine acetylation modulates s-OPA1 GTPase activity and oligomerization in mitochondrial membrane remodeling., PMID:40437978
An integrated approach using morphological, biochemical, and RAPD markers to assess the genetic diversity of Olive (Olea Europaea L.) cultivars in India., PMID:40436990
Mito-TEMPO Mitigates Fibromyalgia Induced by Reserpine in Rats: Orchestration Between SIRT1, Mitochondrial Dynamics, Endoplasmic Reticulum and miRNA-320., PMID:40434586
Soluble Epoxide Hydrolase Inhibition Improves Alzheimer's Disease Hallmarks: Correlation with Peripheral Inflammation and Gut Microbiota Modulation., PMID:40423637
Membrane ATPases and Mitochondrial Proteins in Fetal Cerebellum After Exposure to L-Glutamate During Gestation., PMID:40422762
Review of FUNDC1-mediated mitochondrial autophagy in Alzheimer's disease., PMID:40421101
Chronic mild stress disrupts mitophagy and mitochondrial status in rat frontal cortex., PMID:40410878
SIRT1 and its SUMOylation attenuate hyperoxia-induced lung injury by improving mitochondrial biogenesis and fusion., PMID:40403939
1,25(OH)2D3 up-regulated mitochondrial dynamics and biogenesis to modulate steroidogenesis in the scent glands of muskrats (Ondatra zibethicus)., PMID:40398522
Cold storage effects on mitochondrial bioenergetics and protein expression in human mesenchymal stromal cells., PMID:40380957
Molecular machineries shaping the mitochondrial inner membrane., PMID:40369159
Optic Atrophy 1: The Conductor of Cellular Harmony and Age-Related Pathologies., PMID:40354380
[Clematichinenoside AR protects bone marrow mesenchymal stem cells from hypoxia-induced apoptosis by maintaining mitochondrial homeostasis]., PMID:40350916
[Verification of resveratrol ameliorating vascular endothelial damage in sepsis-associated encephalopathy through HIF-1α pathway based on network pharmacology and experiment]., PMID:40350824
Identification of NDUFV2, NDUFS7, OPA1, and NDUFA1 as biomarkers for Alzheimer's disease: Insights from oxidative stress and mitochondrial dysfunction in the hippocampus., PMID:40329774
Metformin restores mitochondrial bioenergetics and redox homeostasis through modulation of mitochondrial biogenesis and dynamics in patient derived cultured fibroblasts and an animal model of molybdenum cofactor deficiency., PMID:40327990
Mechanistic study of modulating mitochondrial fission and fusion to ameliorate neuropathic pain in mice., PMID:40320455
Cytochrome P450 2E1 aggravates DXR-induced myocardial injury through imbalanced mitochondrial OPA1., PMID:40307912
Gui-Pi-Tang Defers Skeletal Muscle and Cardiac Muscle Aging by Promoting Mitochondrial Remodeling., PMID:40291160
Mitofusin-Mediated Mitochondrial Fusion Inhibits Pseudorabies Virus Infection in Porcine Cells., PMID:40284870
OPA1 mutations in dominant optic atrophy: domain-specific defects in mitochondrial fusion and apoptotic regulation., PMID:40275276
Mitochondrial protein OPA1 is required for the expansion of effector CD8 T cells., PMID:40261796
MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes., PMID:40258148
YME1L1 Dysfunction Associated With 3-Methylglutaconic Aciduria., PMID:40255048
The effects of different exercise training protocols on mitochondrial dynamics in skeletal and cardiac muscles of Wistar rats., PMID:40251584
Leptin attenuates diabetic cardiomyopathy-induced cardiac remodeling via regulating cGAS/STING signaling and Opa1-mediated mitochondrial fusion., PMID:40246132
ROS-DRP1-mediated excessive mitochondrial fission and autophagic flux inhibition contribute to heat stress-induced apoptosis in goat Sertoli cells., PMID:40234984
Consecutive skeletal muscle PGC-1α overexpression: A double-edged sword for mitochondrial health in the aging brain., PMID:40228677
Polysaccharides from Ganoderma lucidum attenuate cognitive impairment in 5xFAD mice by inhibiting oxidative stress and modulating mitochondrial dynamics via the Nrf2/antioxidative axis activation., PMID:40227285
Schisandrin B regulates mitochondrial dynamics via AKT1 activation and mitochondrial targeting to ameliorate renal ischemia-reperfusion injury., PMID:40220406
Novel in vivo models of autosomal optic atrophy reveal conserved pathological changes in neuronal mitochondrial structure and function., PMID:40202868
Tetrahydrobenzimidazole TMQ0153 targets OPA1 and restores drug sensitivity in AML via ROS-induced mitochondrial metabolic reprogramming., PMID:40197337
Harmine derivative H-2-168 induces the death of Echinococcus granulosus by regulating mitochondrial fusion and fission., PMID:40188381
Mitochondrial fusion protein: a new therapeutic target for lung injury diseases., PMID:40177356
Voluntary Exercise Attenuates Tumor Growth in a Preclinical Model of Castration-Resistant Prostate Cancer., PMID:40173332
Cardiomyopathy in a c.1528G>C Hadha mouse is associated with cardiac tissue lipotoxicity and altered cardiolipin species., PMID:40164334
Fibroblast growth factor 8 (FGF8) induces mitochondrial remodeling in chondrocytes via ERK/AMPK signaling pathway., PMID:40162651
The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease., PMID:40149969
Exploiting Paradoxical Activation of Oncogenic MAPK Signaling by Targeting Mitochondria to Sensitize NRAS Mutant-Melanoma to Vemurafenib., PMID:40141318
Dihydromyricetin ameliorates lipopolysaccharide‒induced hepatic injury in chickens by activating the Nrf2/Keap1 pathway and regulating mitochondrial dynamics., PMID:40132312
Clioquinol induces mitochondrial toxicity in SH-SY5Y neuroblastoma cells by affecting the respiratory chain complex IV and OPA1 dynamin-like GTPase., PMID:40125820
H2S remodels mitochondrial ultrastructure and destabilizes respiratory supercomplexes., PMID:40120684
For research use only. Not for human or drug use.
