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Anti-Human CD200R1/OX2R Antibody (OX-108), APC

Catalog #:   FHJ27913 Specific References (100) DATASHEET
Host species: Mouse
Isotype: IgG1, kappa
Applications: FCM
Accession: Q8TD46
Overview

Catalog No.

FHJ27913

Species reactivity

Human

Host species

Mouse

Isotype

IgG1, kappa

Clonality

Monoclonal

Conjugation

APC

Target

MOX2R, Cell surface glycoprotein OX2 receptor 1, OX2R, Cell surface glycoprotein CD200 receptor 1, CD200R, CD200 cell surface glycoprotein receptor, CRTR2, CD200R1

Concentration

0.5 mg/ml

Endotoxin level

Please contact with the lab for this information.

Accession

Q8TD46

Applications

FCM

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Stability and Storage

Store at 4°C for 12 months. Protect from light. Do not freeze.

Clone ID

OX-108

Data Image
References

Ucenprubart is an agonistic antibody to CD200R with the potential to treat inflammatory skin disease: preclinical development and a phase 1 clinical study., PMID:40312358

Ucenprubart is an agonistic antibody to CD200R with the potential to treat inflammatory skin disease: preclinical development and a phase 1 clinical study., PMID:40312358

Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway., PMID:40049088

Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway., PMID:40049088

First-in-Human Study of 23ME-00610, an Antagonistic Antibody for Genetically Validated CD200R1 Immune Checkpoint, in Participants with Advanced Solid Malignancies., PMID:39651931

First-in-Human Study of 23ME-00610, an Antagonistic Antibody for Genetically Validated CD200R1 Immune Checkpoint, in Participants with Advanced Solid Malignancies., PMID:39651931

CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody., PMID:39402718

CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody., PMID:39402718

Endothelial Cell-Derived Soluble CD200 Determines the Ability of Immune Cells to Cross the Blood-Brain Barrier., PMID:39273210

Endothelial Cell-Derived Soluble CD200 Determines the Ability of Immune Cells to Cross the Blood-Brain Barrier., PMID:39273210

Activation of the CD200/CD200R1 axis improves cognitive impairment by enhancing hippocampal neurogenesis via suppression of M1 microglial polarization and neuroinflammation in hypoxic-ischemic neonatal rats., PMID:38237226

Activation of the CD200/CD200R1 axis improves cognitive impairment by enhancing hippocampal neurogenesis via suppression of M1 microglial polarization and neuroinflammation in hypoxic-ischemic neonatal rats., PMID:38237226

Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice., PMID:37902837

Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice., PMID:37902837

Different mechanisms of CD200-CD200R induce diverse outcomes in cancer treatment., PMID:37734537

Different mechanisms of CD200-CD200R induce diverse outcomes in cancer treatment., PMID:37734537

23ME-00610, a genetically informed, first-in-class antibody targeting CD200R1 to enhance antitumor T cell function., PMID:37288324

23ME-00610, a genetically informed, first-in-class antibody targeting CD200R1 to enhance antitumor T cell function., PMID:37288324

Transcriptome analysis of Homo sapiens and Mus musculus reveals mechanisms of CD8+ T cell exhaustion caused by different factors., PMID:36084049

Transcriptome analysis of Homo sapiens and Mus musculus reveals mechanisms of CD8+ T cell exhaustion caused by different factors., PMID:36084049

Reduced cutaneous CD200:CD200R1 signaling in psoriasis enhances neutrophil recruitment to skin., PMID:35759230

Reduced cutaneous CD200:CD200R1 signaling in psoriasis enhances neutrophil recruitment to skin., PMID:35759230

CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury., PMID:35681481

CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury., PMID:35681481

CD200R family receptors are expressed on porcine monocytes and modulate the production of IL-8 and TNF-α triggered by TLR4 or TLR7 in these cells., PMID:35231818

CD200R family receptors are expressed on porcine monocytes and modulate the production of IL-8 and TNF-α triggered by TLR4 or TLR7 in these cells., PMID:35231818

Soporific effect of modified Suanzaoren Decoction on mice models of insomnia by regulating Orexin-A and HPA axis homeostasis., PMID:34509822

Soporific effect of modified Suanzaoren Decoction on mice models of insomnia by regulating Orexin-A and HPA axis homeostasis., PMID:34509822

CD200R1 and CD200R1L expression is regulated during B cell development in swine and modulates the Ig production in response to the TLR7 ligand imiquimoid., PMID:33961666

CD200R1 and CD200R1L expression is regulated during B cell development in swine and modulates the Ig production in response to the TLR7 ligand imiquimoid., PMID:33961666

CD200R1L is a functional evolutionary conserved activating receptor in human neutrophils., PMID:33884657

CD200R1L is a functional evolutionary conserved activating receptor in human neutrophils., PMID:33884657

The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson's disease., PMID:33823877

The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson's disease., PMID:33823877

Activation of pro- and anti-inflammatory responses in lung tissue injury during the acute phase of PRRSV-1 infection with the virulent strain Lena., PMID:32605751

Activation of pro- and anti-inflammatory responses in lung tissue injury during the acute phase of PRRSV-1 infection with the virulent strain Lena., PMID:32605751

Increased CD200 levels in peripheral blood mononuclear cells of patients with primary Sjögren's syndrome., PMID:32180363

Increased CD200 levels in peripheral blood mononuclear cells of patients with primary Sjögren's syndrome., PMID:32180363

TAK-925, an orexin 2 receptor-selective agonist, shows robust wake-promoting effects in mice., PMID:31654653

TAK-925, an orexin 2 receptor-selective agonist, shows robust wake-promoting effects in mice., PMID:31654653

Bone marrow-mesenchymal stem cells modulate microglial activation in the peri-infarct area in rats during the acute phase of stroke., PMID:31589902

Bone marrow-mesenchymal stem cells modulate microglial activation in the peri-infarct area in rats during the acute phase of stroke., PMID:31589902

Analysis of the expression of porcine CD200R1 and CD200R1L by using newly developed monoclonal antibodies., PMID:31233758

Analysis of the expression of porcine CD200R1 and CD200R1L by using newly developed monoclonal antibodies., PMID:31233758

CD200Fc Improves Neurological Function by Protecting the Blood-brain Barrier after Intracerebral Hemorrhage., PMID:31208229

CD200Fc Improves Neurological Function by Protecting the Blood-brain Barrier after Intracerebral Hemorrhage., PMID:31208229

Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer., PMID:30179225

Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer., PMID:30179225

CD200 modulates spinal cord injury neuroinflammation and outcome through CD200R1., PMID:29870752

CD200 modulates spinal cord injury neuroinflammation and outcome through CD200R1., PMID:29870752

Anti-inflammation conferred by stimulation of CD200R1 via Dok1 pathway in rat microglia after germinal matrix hemorrhage., PMID:28792282

Anti-inflammation conferred by stimulation of CD200R1 via Dok1 pathway in rat microglia after germinal matrix hemorrhage., PMID:28792282

CD200Fc reduces LPS-induced IL-1β activation in human cervical cancer cells by modulating TLR4-NF-κB and NLRP3 inflammasome pathway., PMID:28402258

CD200Fc reduces LPS-induced IL-1β activation in human cervical cancer cells by modulating TLR4-NF-κB and NLRP3 inflammasome pathway., PMID:28402258

Impact of antibody subclass and disulfide isoform differences on the biological activity of CD200R and βklotho agonist antibodies., PMID:28363871

Impact of antibody subclass and disulfide isoform differences on the biological activity of CD200R and βklotho agonist antibodies., PMID:28363871

Importance of CD200 expression by tumor or host cells to regulation of immunotherapy in a mouse breast cancer model., PMID:28234914

Importance of CD200 expression by tumor or host cells to regulation of immunotherapy in a mouse breast cancer model., PMID:28234914

Monocytes, microglia, and CD200-CD200R1 signaling are essential in the transmission of inflammation from the periphery to the central nervous system., PMID:28164283

Monocytes, microglia, and CD200-CD200R1 signaling are essential in the transmission of inflammation from the periphery to the central nervous system., PMID:28164283

A comparison of serum miRNAs influencing metastatic growth of EMT6 vs 4THM tumor cells in wild-type and CD200R1KO mice., PMID:28160157

A comparison of serum miRNAs influencing metastatic growth of EMT6 vs 4THM tumor cells in wild-type and CD200R1KO mice., PMID:28160157

Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis., PMID:27929051

Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis., PMID:27929051

CD200Fc attenuates inflammatory responses and maintains barrier function by suppressing NF-κB pathway in cigarette smoke extract induced endothelial cells., PMID:27710895

CD200Fc attenuates inflammatory responses and maintains barrier function by suppressing NF-κB pathway in cigarette smoke extract induced endothelial cells., PMID:27710895

Impact of CD200-Fc on dendritic cells in lupus-prone NZB/WF1 mice., PMID:27545083

Impact of CD200-Fc on dendritic cells in lupus-prone NZB/WF1 mice., PMID:27545083

[CD200/CD200R Expression Levels and Its Significance after Allogeneic Hematopoietic Stem Cell Transplantation]., PMID:27342516

[CD200/CD200R Expression Levels and Its Significance after Allogeneic Hematopoietic Stem Cell Transplantation]., PMID:27342516

Characterization of CD200 Ectodomain Shedding., PMID:27111430

Characterization of CD200 Ectodomain Shedding., PMID:27111430

Immune checkpoint inhibitors enhance cytotoxicity of cytokine-induced killer cells against human myeloid leukaemic blasts., PMID:26961084

Immune checkpoint inhibitors enhance cytotoxicity of cytokine-induced killer cells against human myeloid leukaemic blasts., PMID:26961084

CD200Fc reduces TLR4-mediated inflammatory responses in LPS-induced rat primary microglial cells via inhibition of the NF-κB pathway., PMID:26956766

CD200Fc reduces TLR4-mediated inflammatory responses in LPS-induced rat primary microglial cells via inhibition of the NF-κB pathway., PMID:26956766

Involvement of the orexin/hypocretin system in the pharmacological effects induced by Δ(9) -tetrahydrocannabinol., PMID:26799708

Involvement of the orexin/hypocretin system in the pharmacological effects induced by Δ(9) -tetrahydrocannabinol., PMID:26799708

Evaluation of the antigenicity of hydrolyzed cow's milk protein formulas using the mouse basophil activation test., PMID:26626100

Evaluation of the antigenicity of hydrolyzed cow's milk protein formulas using the mouse basophil activation test., PMID:26626100

Decreased expression of CD200R3 on mouse basophils as a novel marker for IgG1-mediated anaphylaxis., PMID:26417442

Decreased expression of CD200R3 on mouse basophils as a novel marker for IgG1-mediated anaphylaxis., PMID:26417442

The CD200 tolerance-signaling molecule and its receptor, CD200R1, are expressed in human placental villus trophoblast and in peri-implant decidua by 5 weeks' gestation., PMID:26123445

The CD200 tolerance-signaling molecule and its receptor, CD200R1, are expressed in human placental villus trophoblast and in peri-implant decidua by 5 weeks' gestation., PMID:26123445

The Receptor for the CD200 Tolerance-Signaling Molecule Associated with Successful Pregnancy is Expressed by Early-Stage Breast Cancer Cells in 80% of Patients and by Term Placental Trophoblasts., PMID:26011475

The Receptor for the CD200 Tolerance-Signaling Molecule Associated with Successful Pregnancy is Expressed by Early-Stage Breast Cancer Cells in 80% of Patients and by Term Placental Trophoblasts., PMID:26011475

Local targeting of the CD200-CD200R axis does not promote corneal graft survival., PMID:25450061

Local targeting of the CD200-CD200R axis does not promote corneal graft survival., PMID:25450061

Comparison of immunity in mice cured of primary/metastatic growth of EMT6 or 4THM breast cancer by chemotherapy or immunotherapy., PMID:25409195

Comparison of immunity in mice cured of primary/metastatic growth of EMT6 or 4THM breast cancer by chemotherapy or immunotherapy., PMID:25409195

Aberrant CD200/CD200R1 expression and its potential role in Th17 cell differentiation, chemotaxis and osteoclastogenesis in rheumatoid arthritis., PMID:25261692

Aberrant CD200/CD200R1 expression and its potential role in Th17 cell differentiation, chemotaxis and osteoclastogenesis in rheumatoid arthritis., PMID:25261692

The CD200-CD200 receptor inhibitory axis controls arteriogenesis and local T lymphocyte influx., PMID:24897500

The CD200-CD200 receptor inhibitory axis controls arteriogenesis and local T lymphocyte influx., PMID:24897500

The CD200-CD200R1 inhibitory signaling pathway: immune regulation and host-pathogen interactions., PMID:24388216

The CD200-CD200R1 inhibitory signaling pathway: immune regulation and host-pathogen interactions., PMID:24388216

Anti-CD200R2, anti-IL-9, anti-IL-35, or anti-TGF-β abolishes increased graft survival and Treg induction induced in cromolyn-treated CD200R1KO.CD200tg mice., PMID:24142033

Anti-CD200R2, anti-IL-9, anti-IL-35, or anti-TGF-β abolishes increased graft survival and Treg induction induced in cromolyn-treated CD200R1KO.CD200tg mice., PMID:24142033

Dissection of agonistic and blocking effects of CD200 receptor antibodies., PMID:23691022

Dissection of agonistic and blocking effects of CD200 receptor antibodies., PMID:23691022

Datasheet
$ 292
Product specifications
50 T 292 100 T 484

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Anti-Human CD200R1/OX2R Antibody (OX-108), APC [FHJ27913]
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