Catalog No.
FHH06113
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Conjugation
APC
Target
HER4, Tyrosine kinase-type cell surface receptor HER4, p180erbB4, s80HER4, ERBB4, 4ICD, Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, E4ICD
Concentration
0.5 mg/ml
Endotoxin level
Please contact with the lab for this information.
Accession
Q15303
Applications
FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Stability and Storage
Store at 4°C for 12 months. Protect from light. Do not freeze.
Clone ID
mAb1479
HER3-targeting Antibody-drug Conjugates Therapy for Solid Tumors: Recent Advances and Future Potentials., PMID:39995133
The FGFR inhibitor Rogaratinib reduces microglia reactivity and synaptic loss in TBI., PMID:39635532
Pre-radiation Nivolumab plus ipilimumab in patients with newly diagnosed high-grade gliomas., PMID:39572979
Retraction notice to "The novel antibody fusion protein rhNRG1-HER3i promotes heart regeneration by enhancing NRG1-ERBB4 signaling pathway" [Journal of Molecular and Cellular Cardiology 187 (2023) 26-37]., PMID:39551682
Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer., PMID:38369520
The novel antibody fusion protein rhNRG1-HER3i promotes heart regeneration by enhancing NRG1-ERBB4 signaling pathway., PMID:38150867
Clinicopathological significance of concurrent ErbB receptor expression in human meningioma., PMID:37719042
Molecular features and clinical implications of the heterogeneity in Chinese patients with HER2-low breast cancer., PMID:37607916
Extensive cytokine biomarker analysis in serum of Guillain-Barré syndrome patients., PMID:37221406
Life after Cleavage: The Story of a β-Retroviral (MMTV) Signal Peptide-From Murine Lymphoma to Human Breast Cancer., PMID:36366533
Neuregulin 4 Boosts the Efficacy of Anti-ERBB2 Neutralizing Antibodies., PMID:35664762
Targeting of ErbB1, ErbB2, and their Dual Targeting Using Small Molecules and Natural Peptides: Blocking EGFR Cell Signaling Pathways in Cancer: A Mini-Review., PMID:35549881
Recent Advances in Epidermal Growth Factor Receptor Inhibitors (EGFRIs) and their Role in the Treatment of Cancer: A Review., PMID:35400324
Diagnosis and Treatment of ERBB2-Positive Metastatic Colorectal Cancer: A Review., PMID:35238866
Progress in Treatment of Non-Small Cell Lung Cancer Harboring HER2 Aberrations., PMID:34262294
Targeting the PI3K and MAPK pathways to improve response to HER2-targeted therapies in HER2-positive gastric cancer., PMID:33933113
Fibroblast growth factor receptor facilitates recurrence of minimal residual disease following trastuzumab emtansine therapy., PMID:33479246
mTOR kinase inhibition disrupts neuregulin 1-ERBB3 autocrine signaling and sensitizes NF2-deficient meningioma cellular models to IGF1R inhibition., PMID:33273014
PDL1 high expression without TP53, KEAP1 and EPHA5 mutations could better predict survival for patients with NSCLC receiving atezolizumab., PMID:33246647
Long-acting antibody ligand mimetics for HER4-selective agonism., PMID:33057063
Neratinib plus capecitabine for the treatment of advanced HER2-positive breast cancer., PMID:32862744
ErbB1-dependent signalling and vesicular trafficking in primary afferent nociceptors associated with hypersensitivity in neuropathic pain., PMID:32531343
Biasing human epidermal growth factor receptor 4 (HER4) tyrosine kinase signaling with antibodies: Induction of cell death by antibody-dependent HER4 intracellular domain trafficking., PMID:32415868
HOTAIR Competitively Binds MiRNA330 as a Molecular Sponge to Increase the Resistance of Gastric Cancer to Trastuzumab., PMID:32364078
The dichotomous role of epiregulin in pain., PMID:31917773
High-Throughput Generation of Bispecific Binding Proteins by Sortase A-Mediated Coupling for Direct Functional Screening in Cell Culture., PMID:31871271
KRAS and ERBB-family genetic alterations affect response to PD-1 inhibitors in metastatic nonsquamous NSCLC., PMID:31798692
Molecular Targeting Therapy against EGFR Family in Breast Cancer: Progress and Future Potentials., PMID:31756933
Avidity-Based Affinity Enhancement Using Nanoliposome-Amplified SPR Sensing Enables Low Picomolar Detection of Biologically Active Neuregulin 1., PMID:31724395
The origin of NMDA receptor hypofunction in schizophrenia., PMID:31629007
HER3 and HER4 are highly expressed in human meningiomas., PMID:31400925
ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms., PMID:31291965
Evaluation of the prognostic value of all four HER family receptors in patients with metastatic breast cancer treated with trastuzumab: A Hellenic Cooperative Oncology Group (HeCOG) study., PMID:30521571
Small molecule inhibitors targeting the EGFR/ErbB family of protein-tyrosine kinases in human cancers., PMID:30500458
ErbB4/KITENIN-Mediated Signaling is Activated in Cetuximab-Resistant Colorectal Cancer Cells., PMID:30360226
Understanding the biology of HER3 receptor as a therapeutic target in human cancer., PMID:30109175
HER3 signaling and targeted therapy in cancer., PMID:30057690
Roles of human epidermal growth factor receptor family in pulmonary lymphangioleiomyomatosis., PMID:30030119
Dual Targeting of ERBB2/ERBB3 for the Treatment of SLC3A2-NRG1-Mediated Lung Cancer., PMID:29959202
Antibody-mediated stabilization of NRG1 induces behavioral and electrophysiological alterations in adult mice., PMID:29844389
Analysis of HER Family (HER1-4) Expression as a Biomarker in Combination Therapy with Pertuzumab, Trastuzumab and Docetaxel for Advanced HER2-positive Breast Cancer., PMID:29599351
The HER4-YAP1 axis promotes trastuzumab resistance in HER2-positive gastric cancer by inducing epithelial and mesenchymal transition., PMID:29535422
Los receptores epidérmicos humanos en el cáncer gástrico: alteraciones moleculares y su papel como diana terapéutica., PMID:29414960
Epidermal Growth Factor Receptor Tyrosine Kinase: A Potential Target in Treatment of Non-Small-Cell Lung Carcinoma., PMID:29199595
siRNA-mediated inactivation of HER3 improves the antitumour activity and sensitivity of gefitinib in gastric cancer cells., PMID:28881753
Assessment of Specificity of an Adenovirus Targeted to HER3/4., PMID:28791648
Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies., PMID:28750640
Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121)., PMID:28725482
Specific antibodies and sensitive immunoassays for the human epidermal growth factor receptors (HER2, HER3, and HER4)., PMID:28653892
For research use only. Not for human or drug use.
