Catalog No.
YHA80301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp24-Glu480
Predicted molecular weight
53.65 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43854
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
EDIL3, Integrin-binding protein DEL1, DEL1, Developmentally-regulated endothelial cell locus 1 protein, EGF-like repeat and discoidin I-like domain-containing protein 3
Rationale and feasibility of a rapid integral biomarker program that informs immune-oncology clinical trials: the ADVISE trial., PMID:40389374
Identification and functional characterization of hub genes CLTA, EDIL3, HAPLN1, and HIP1 as diagnostic biomarkers and therapeutic targets in thyroid cancer and Hashimoto's thyroiditis., PMID:40372556
Targeted plasma proteomics reveals organ damage signatures of AIDS- and noncommunicable disease-related deaths in people with HIV., PMID:40274826
Developmental Endothelial Locus-1 Promotes Osteoclast Differentiation and Activation., PMID:40141315
Long-term outcomes among patients who respond within the first year to nivolumab plus ipilimumab or nivolumab monotherapy: A pooled analysis in 935 patients., PMID:39612757
Targeting RAF1 gene fusions with MEK inhibition in metastatic melanoma., PMID:39504576
Inhibition of ATM or ATR in combination with hypo-fractionated radiotherapy leads to a different immunophenotype on transcript and protein level in HNSCC., PMID:39411143
Analysis of ANO6, HAPLN1, and EDIL3 Polymorphisms in Patients with Ankylosing Spondylitis in a Chinese Han Population: A Case-Control Study., PMID:39358671
Evaluation of salivary interleukin-17 and developmental endothelial locus-1 in patients with periodontitis with and without type 2 diabetes mellitus., PMID:39311693
EDIL3 alleviates Mannan-induced psoriatic arthritis by slowing the intracellular glycolysis process in mononuclear-derived dendritic cells., PMID:39289212
Nivolumab maintenance improves overall survival of patients with advanced melanoma who experience severe immune-related adverse events on nivolumab plus ipilimumab., PMID:39209453
Developmental endothelial locus 1: the present and future of an endogenous factor in vessels., PMID:39206385
Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer., PMID:39190534
Genetic variants associated with immune-mediated liver injury from checkpoint inhibitors., PMID:39185906
In silico analysis of DEL-1 and inflammation-related genes in lung squamous cell carcinoma., PMID:39089131
Nischarin inhibits the epithelial-mesenchymal transition process and angiogenesis in breast cancer cells by inactivating FAK/ERK signaling pathway via EGF like repeats and discoidin domains 3., PMID:39023636
A novel prognostic signature related to programmed cell death in osteosarcoma., PMID:39015570
Key genes and molecular mechanisms related to Paclitaxel Resistance., PMID:39003454
Oncogenic and immunological role of EDIL3 in human tumours: From pan-cancer analysis to validation in gastric cancer., PMID:38882287
EDIL3/Del-1 prevents aortic dissection through enhancing internalization and degradation of apoptotic vascular smooth muscle cells., PMID:38873925
System analysis based on Anoikis-related genes identifies MAPK1 as a novel therapy target for osteosarcoma with neoadjuvant chemotherapy., PMID:38835052
Epidermal Growth Factor-Like Repeats and Discoidin I-Like Domains 3 Deficiency Attenuates Dilated Cardiomyopathy by Inhibiting Ubiquitin Specific Peptidase 10 Dependent Smad4 Deubiquitination., PMID:38456416
Dysregulation of the Skin-Liver Axis in Prurigo Nodularis: An Integrated Genomic, Transcriptomic, and Population-Based Analysis., PMID:38397136
Del-1 Plays a Protective Role against COPD Development by Inhibiting Inflammation and Apoptosis., PMID:38396634
Exploration of MELK as a downstream of Del-1 and druggable targets in triple-negative breast cancer., PMID:38279017
An IL-10/DEL-1 axis supports granulopoiesis and survival from sepsis in early life., PMID:38263289
Comparison of the extracellular vesicle proteome between glaucoma and non-glaucoma trabecular meshwork cells., PMID:38223904
The role of EDIL3 in maintaining cartilage extracellular matrix and inhibiting osteoarthritis development., PMID:38081212
DEL-1 deficiency aggravates pressure overload-induced heart failure by promoting neutrophil infiltration and neutrophil extracellular traps formation., PMID:37956894
EDIL3 as an Angiogenic Target of Immune Exclusion Following Checkpoint Blockade., PMID:37728484
Decreased GCF DEL-1 and increased GCF neutrophils with increasing probing pocket depth., PMID:37681356
DEL-1, as an anti-neutrophil transepithelial migration molecule, inhibits airway neutrophilic inflammation in asthma., PMID:37681299
Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model., PMID:37657448
EDIL3 is a potential prognostic biomarker that correlates with immune infiltrates in gastric cancer., PMID:37576496
Construction of stomach adenocarcinoma prognostic signature based on anoikis-related lncRNAs and clinical significance., PMID:37300839
EDIL3 and VEGF Synergistically Affect Angiogenesis in Endothelial Cells., PMID:37223216
Presence of coronary aneurysms during Kawasaki Disease (KD) correlates with lower levels of autoantibodies to both full form and spliced variant of immune regulator Del-1., PMID:37019289
Putative critical quality attribute matrix identifies mesenchymal stromal cells with potent immunomodulatory and angiogenic "fitness" ranges in response to culture process parameters., PMID:36532069
Bioinformatics analysis and identification of dysregulated POSTN in the pathogenesis of keloid., PMID:36517972
Proteomic Analysis of Pleural Effusions from COVID-19 Deceased Patients: Enhanced Inflammatory Markers., PMID:36428847
EDIL3 influenced the αvβ3-FAK/MEK/ERK axis of endothelial cells in psoriasis., PMID:36065978
Intrarenal Single-Cell Sequencing of Hepatitis B Virus Associated Membranous Nephropathy., PMID:35935760
Highly sensitive fluorescent detection of EDIL3 overexpressed exosomes for the diagnosis of triple-negative breast cancer., PMID:35820407
Variants Within Genes EDIL3 and ADGRB3 are Associated With Divergent Fecal Egg Counts in Katahdin Sheep at Weaning., PMID:35360858
Genome Wide Scan to Identify Potential Genomic Regions Associated With Milk Protein and Minerals in Vrindavani Cattle., PMID:35359668
Impact of smoking on cardiovascular risk and premature ageing: Findings from the STANISLAS cohort., PMID:35247627
Developmental endothelial locus-1 protects from hypertension-induced cardiovascular remodeling via immunomodulation., PMID:35133978
Sustained developmental endothelial locus-1 overexpression promotes spinal cord injury recovery in mice through the SIRT1/SERCA2 signaling pathway., PMID:35093467
Identification and Clinical Validation of Key Extracellular Proteins as the Potential Biomarkers in Relapsing-Remitting Multiple Sclerosis., PMID:34950135
Developmental endothelial locus-1 as a potential biomarker for the incidence of acute exacerbation in patients with chronic obstructive pulmonary disease., PMID:34801026
For research use only. Not for human or drug use.
