Catalog No.
YHA72601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln34-Met97
Predicted molecular weight
9.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43612
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HCRT, OX, Hcrt2, Hcrt, PPOX, PPORX, Hypocretin, Hypocretin-2, Hcrt1, Hypocretin-1, Orexin
Investigating the effects of Orexin receptor 1 antagonism on decision making under uncertainty., PMID:40484250
Distribution of Orexigenic Orexin-A, Anorexigenic CRF and MCH at the Levels of Preoptic Area and Hypothalamus in the Conger Eel Brain., PMID:40476480
Potential role of Amyloid-β on the association between Orexin-A and blood-brain barrier leakage of globus pallidus in Alzheimer's disease and dementia with lewy bodies., PMID:40457423
Transcutaneous auricular vagus nerve stimulation inhibits food intake and body weight gain through the orexin dependent pathway in high fat diet mice., PMID:40456821
Cerebrospinal Fluid Biomarkers in Opioid Dependence: Evidence of Neuroimmune Activation and Ion Composition Changes, Without Alteration in Orexin-A., PMID:40454659
TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice., PMID:40426231
Regulation of the gut-brain-pituitary-gonad axis in tilapia: Evidence for the involvement of orexin., PMID:40424869
[Orexin-A promotes motor function recovery of rats with spinal cord injury by regulating ionotropic glutamate receptors]., PMID:40415434
Microcystis aeruginosa decreased fish appetite via inducing intestinal inflammation., PMID:40414470
Effects of inhibiting the orexin system on nicotine reward memory and fear memory., PMID:40398734
How may the hypothalamus control distinct types and stages of memory?, PMID:40381884
Unraveling the pathophysiology of narcolepsy type 1 through hypothesis-driven and hypothesis-generating approaches., PMID:40373365
The role and interaction of hypothalamic-related neurotransmitters in migraine., PMID:40350428
Associations of CO2 reactivity and orexin activity with extinction memory to fear and reward cues: results from a large sample of male rats across multiple studies., PMID:40350068
Orexin Restoration in Narcolepsy: Breakthroughs in Cellular Therapy., PMID:40325840
Detection of reduced orexin-A/hypocretin-1 and its fragments by orexin-A "gold-standard" radioimmunoassay., PMID:40250157
An orexin agonist promotes wakefulness and inhibits cataplexy through distinct brain regions., PMID:40233754
An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour., PMID:40229262
Influence of Intermittent Fasting on Body Composition, Physical Performance, and the Orexinergic System in Postmenopausal Women: A Pilot Study., PMID:40218879
Compensatory enhancement of orexinergic system functionality induced by amyloid-β protein: a neuroprotective response in Alzheimer's disease., PMID:40196718
Agonists for glutamate, acetylcholine, and orexin cause non-photic phase shifts when applied to the intergeniculate leaflet., PMID:40194656
Evaluation of leptin, insulin, orexin, neuropeptide y (NPY) levels in postmortem CSF samples in suicide deaths., PMID:40187429
Clinical and objective correlates of disrupted nighttime sleep in pediatric narcolepsy type 1., PMID:40179666
Brain AMPK signaling improves intestinal barrier function through brain orexin and the vagal pathway in rats., PMID:40158792
Evaluation of Orexin-A, Adiponectin and Apelin-13 Serum Levels in Children Diagnosed With Attention Deficit Hyperactivity Disorder., PMID:40156238
Orexin receptors: possible therapeutic targets for psychiatric disorders., PMID:40153060
The Orexin System and Its Impact on the Autonomic Nervous and Cardiometabolic System in Post-Acute Sequelae of COVID-19., PMID:40149526
Projectome-based characterization of hypothalamic peptidergic neurons in male mice., PMID:40140607
[Symptomatic narcolepsy type 2 in a patient with AQP4-positive neuromyelitis optica spectrum disorder]., PMID:40139811
Effects of increasing n3:n6 ratio by replacing extruded soybeans with extruded flaxseed on dry matter intake, rumen fluid bacteria, and liver lipid metabolism in transition cows., PMID:40087566
Modelling orexinergic system in ageing in the African turquoise killifish., PMID:40085285
Use of Portable 24-Hour Polysomnography as Alternative Diagnostic Tool for Narcolepsy Type 1 in Adults and Children., PMID:40080737
Glucose and energy metabolism are impaired in mice deficient for orexins., PMID:40066929
Auditory fear memory retrieval requires BLA-LS and LS-VMH circuitries via GABAergic and dopaminergic neurons., PMID:40055468
Evaluation of The Impact of Hypocretin Receptor 1 rs2271933 Polymorphism on Sleep Components in Chronic Migraine Patients with Poor Sleep Quality: A Subgroup Analysis., PMID:40046196
[Narcolepsy type 1 and hypocretin neurons]., PMID:40025890
Unexpected Conversion of Tyrosine into a Coumaric Acid Residue at the N-Terminal Side of an Orexin Peptide Fragment Induced by UV Irradiation., PMID:40019305
The Complexly Parcellated, Yet Quantitatively Reduced, Orexinergic/Hypocretinergic System of Humans., PMID:40008540
Alzheimer's disease with depression: clinical characteristics and potential mechanisms involving orexin and brain atrophy., PMID:39994172
Associations of Cerebrospinal Fluid Orexin-A, Alzheimer Disease Biomarkers, and Cognitive Performance., PMID:39957622
Pons metabolite alterations in narcolepsy type 1., PMID:39951174
Orexin/hypocretin receptor 2 signaling in MCH neurons regulates REM sleep and insulin sensitivity., PMID:39946231
Role of OX/OXR cascade in insomnia and sleep deprivation link Alzheimer's disease and Parkinson's disease: Therapeutic avenue of Dual OXR Antagonist (DORA)., PMID:39920976
Hypothalamic GHRH., PMID:39913072
Modulation of noradrenergic signalling reverses stress-induced changes in the hippocampus: Involvement of orexinergic systems., PMID:39909296
Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models., PMID:39879320
Obstructive sleep apnea syndrome, orexin, and sleep-wake cycle: The link with the neurodegeneration., PMID:39864923
Dopamine Drives Feedforward Inhibition to Orexin Feeding System, Mediating Weight Loss Induced by Morphine Addiction., PMID:39836540
The interaction between orexin, sleep deprivation and Alzheimer's disease: Unveiling an Emerging Connection., PMID:39823966
Can serum orexin levels be used as a marker in childhood epilepsy?, PMID:39811283
For research use only. Not for human or drug use.
