Catalog No.
YHA71301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala25-Leu302
Predicted molecular weight
33.55 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43570
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Carbonate dehydratase XII, Carbonic anhydrase XII, Tumor antigen HOM-RCC-3.1.3, CA-XII, Carbonic anhydrase 12, CA12
Alterations in gene expression associated with invasion of RAS-mutant thyroid tumors and their potential diagnostic and therapeutic utility., PMID:40440326
Seminal vesicle protein caCA12 in Corydoras aeneus inhibits sperm motility for sperm drinking., PMID:40371598
Targeted plasma proteomics reveals organ damage signatures of AIDS- and noncommunicable disease-related deaths in people with HIV., PMID:40274826
Integrative analysis reveals key molecular mechanisms and prognostic model for Ethylnitrosourea-induced gliomagenesis., PMID:40264162
The combination of CA125, CA199, CEA, and AFP is an effective diagnostic biomarker for gastric cancer in elderly individuals., PMID:40221735
Development of a prognostic model based on the ceRNA network in Triple-Negative Breast cancer., PMID:40034665
Assessing the diagnostic value of oncological biomarkers for identifying primary malignancies in skeletal metastatic disease., PMID:40009913
WTAP mediates IL-1β-induced chondrocyte injury by enhancing CA12 mRNA stability depending on m6A modification., PMID:39639339
A comprehensive transcriptome characterization of individual nuclear receptor pathways in the human small intestine., PMID:39475639
[Detection of pathogenic gene mutations in thirteen cases of congenital bilateral absence of vas deferens infertility patients]., PMID:39397452
Malignant transformation of ovarian mature cystic teratoma with rupture, elevated serum CA199, CA12, CEA: A case report., PMID:39287252
Assessing the diagnostic utility of serum tumor markers for lung cancer detection in patients with interstitial pneumonia., PMID:39095684
Case report: Three cases of systemic lupus erythematosus presenting primarily with massive ascites and significantly elevated CA-125 levels and a review of pseudo-pseudo Meigs' syndrome in literature., PMID:39081322
Norcantharidin Enhances the Antitumor Effect of 5-Fluorouracil by Inducing Apoptosis of Cervical Cancer Cells: Network Pharmacology, Molecular Docking, and Experimental Validation., PMID:38785510
Unlocking Overexpressed Membrane Proteins to Guide Breast Cancer Precision Medicine., PMID:38611080
Auranofin repurposing for lung and pancreatic cancer: low CA12 expression as a marker of sensitivity in patient-derived organoids, with potentiated efficacy by AKT inhibition., PMID:38515178
Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance., PMID:38502695
Unveiling Novel Urease Inhibitors for Helicobacter pylori: A Multi-Methodological Approach from Virtual Screening and ADME to Molecular Dynamics Simulations., PMID:38396647
A comparative study of diaryl urea molecules with and without sulfonamide group on Carbonic anhydrase IX and XII inhibition and its consequence on breast cancer cells., PMID:38382393
Dynamics of N6-methyladenosine modification during aging and their potential roles in the degeneration of intervertebral disc., PMID:38283178
Simultaneous Assay of CA 72-4, CA 19-9, CEA and CA 125 in Biological Samples Using Needle Three-Dimensional Stochastic Microsensors., PMID:37836876
Recurrent Implantation Failure: Bioinformatic Discovery of Biomarkers and Identification of Metabolic Subtypes., PMID:37686293
Verbascoside: A neuroprotective phenylethanoid glycosides with anti-depressive properties., PMID:37657207
Trafficking of carbonic anhydrase 12 and bicarbonate transporters by histamine stimulation mediates intracellular acidic scenario in lung cancer cells., PMID:37587861
TGM2, HMGA2, FXYD3, and LGALS4 genes as biomarkers in acquired oxaliplatin resistance of human colorectal cancer: A systems biology approach., PMID:37535601
Estrogen-Induced LncRNA, LINC02568, Promotes Estrogen Receptor-Positive Breast Cancer Development and Drug Resistance Through Both In Trans and In Cis Mechanisms., PMID:37404090
Machine-Learning-Based Data Analysis Method for Cell-Based Selection of DNA-Encoded Libraries., PMID:37273617
Therapeutic mechanism of baicalein in peritoneal dialysis-associated peritoneal fibrosis based on network pharmacology and experimental validation., PMID:37266145
Revealing platelet-related subtypes and prognostic signature in pancreatic adenocarcinoma., PMID:37198621
Anticonvulsant Profile of Selected Medium-Chain Fatty Acids (MCFAs) Co-Administered with Metformin in Mice in Acute and Chronic Treatment., PMID:37175220
Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer., PMID:37098526
De Novo Transcriptome Assembly and Comparative Analysis of Differentially Expressed Genes Involved in Cold Acclimation and Freezing Tolerance of the Arctic Moss Aulacomnium turgidum (Wahlenb.) Schwaegr., PMID:36986936
Differential CMS-Related Expression of Cell Surface Carbonic Anhydrases IX and XII in Colorectal Cancer Models-Implications for Therapy., PMID:36982873
The Role of the miR-548au-3p/CA12 Axis in Tracheal Chondrogenesis in Congenital Pulmonary Airway Malformations., PMID:36846718
Indisulam Reduces Viability and Regulates Apoptotic Gene Expression in Pediatric High-Grade Glioma Cells., PMID:36672576
Establishment of a nonshockable rhythm cardiac arrest model caused by asphyxia., PMID:36581829
Proteomic Analysis of Pleural Effusions from COVID-19 Deceased Patients: Enhanced Inflammatory Markers., PMID:36428847
Plasma proteomic characterization of the development of acute kidney injury in early sepsis patients., PMID:36385130
CAXII Is a Surrogate Marker for Luminal Breast Tumors Regulated by ER and GATA3., PMID:36358871
Selection and identification of a specific peptide binding to ovarian cancer cells from a phage-displayed peptide library., PMID:35771408
Metabolomic profile and computational analysis for the identification of the potential anti-inflammatory mechanisms of action of the traditional medicinal plants Ocimum basilicum and Ocimum tenuiflorum., PMID:35461962
Correlation between CA12 and TFF3 and their prediction value of neoadjuvant chemotherapy response in breast cancer., PMID:35229335
Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII., PMID:35069863
First studies on tumor associated carbonic anhydrases IX and XII monoclonal antibodies conjugated to small molecule inhibitors., PMID:35057692
Carbonic anhydrase 12 gene silencing reverses the sensitivity of paclitaxel in drug-resistant breast cancer cells., PMID:34696661
Genetic mutation analysis of 22 patients with congenital absence of vas deferens: a single-center study†., PMID:34673937
Matrine injection inhibits pancreatic cancer growth via modulating carbonic anhydrases- a network pharmacology-based study with in vitro validation., PMID:34597654
Optimization of bioprocess of Schleiferilactobacillus harbinensis Ca12 and its viability in frozen Brazilian berries (Açai, Euterpe oleracea Mart.)., PMID:34510398
Induction of Tertiary Phase Epileptiform Discharges after Postasphyxial Infusion of a Toll-Like Receptor 7 Agonist in Preterm Fetal Sheep., PMID:34205464
The role of HIF proteins in maintaining the metabolic health of the intervertebral disc., PMID:34083809
For research use only. Not for human or drug use.
