Catalog No.
YHA60101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val235-Ser521
Predicted molecular weight
33.86 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43187
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IRAK-2, Interleukin-1 receptor-associated kinase-like 2, IRAK2
Clustering Based on Innate Immunity Reveals Differential Dysregulation Based on Disease Severity in Myelodysplastic Neoplasms., PMID:40397075
IRAK2 overexpression restrains prostate cancer progression by regulation of TRAF6 ubiquitination., PMID:39549822
Diminished expression of the ubiquitin-proteasome system in early treatment-naïve patients with rheumatoid arthritis and concomitant type 2 diabetes may be linked to IL-1 pathway hyper-activity; results from PEAC cohort., PMID:39342401
Severe invasive infections linked to IRAK2 immune variants., PMID:39299377
Dysregulation of Toll-Like Receptor Signaling-Associated Gene Expression in X-Linked Agammaglobulinemia: Implications for Correlations Genotype-Phenotype and Disease Expression., PMID:39116841
The effect of the HMGB1/RAGE/TLR4/NF-κB signalling pathway in patients with idiopathic epilepsy and its relationship with toxoplasmosis., PMID:39046369
IL-1 receptor-associated kinase family proteins: An overview of their role in liver disease., PMID:38936453
Both IRAK3 and IRAK1 Activate the MyD88-TRAF6 Pathway in Zebrafish., PMID:38847613
Identifying allergic-rhinitis-associated genes with random-walk-based method in PPI network., PMID:38697003
OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation., PMID:38605168
Oxomollugin, an oxidized substance in mollugin, inhibited LPS-induced NF-κB activation via the suppressive effects on essential activation factors of TLR4 signaling., PMID:38564154
Effects of immunosuppression-associated gga-miR-146a-5p on immune regulation in chicken macrophages by targeting the IRKA2 gene., PMID:38492902
The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection., PMID:38367238
Alleviating mitochondrial dysfunction in diabetic cardiomyopathy through the Adipsin and Irak2 pathways., PMID:38303084
Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy., PMID:38167325
Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy., PMID:38072993
Immunological characterization of stroke-heart syndrome and identification of inflammatory therapeutic targets., PMID:37965346
Linkage analysis using whole exome sequencing data implicates SLC17A1, SLC17A3, TATDN2 and TMEM131L in type 1 diabetes in Kuwaiti families., PMID:37696853
MiRNA-146a-A Key Player in Immunity and Diseases., PMID:37628949
Emerging trends in IRAK-4 kinase research., PMID:37490192
Kaempferol and Biomodified Kaempferol from Sophora japonica Extract as Potential Sources of Anti-Cancer Polyphenolics against High Grade Glioma Cell Lines., PMID:37445894
Dipotassium Glycyrrhizininate Improves Skin Wound Healing by Modulating Inflammatory Process., PMID:36835248
RNA-Seq Analysis of Clinical Samples from TCGA Reveal Molecular Signatures for Ovarian Cancer., PMID:36797673
IRAK2 Downregulation in Triple-Negative Breast Cancer Cells Decreases Cellular Growth In Vitro and Delays Tumour Progression in Murine Models., PMID:36768848
Hyperfunction variant rs708035 of interleukin 1 receptor-associated kinases 2 gene involved in the predisposition of leprosy infection., PMID:36670053
Interleukin-1 receptor-associated kinase 2 promotes inflammatory reactions by activating the nuclear factor kappa-B signaling pathway in diabetic nephropathy., PMID:38558563
The Heterogeneity of Tumour-Associated Macrophages Contributes to the Recurrence and Outcomes of Glioblastoma Patients., PMID:36542317
Myc-mediated circular RNA circMcph1/miR-370-3p/Irak2 axis is a progressive regulator in hepatic fibrosis., PMID:36435226
Identification of ester-linked ubiquitylation sites during TLR7 signalling increases the number of inter-ubiquitin linkages from 8 to 12., PMID:36408944
The first identification of three AdIRAK2 genes from an evolutionarily important amphibian Andrias davidianus and their involvement in NF-κB activation and inflammatory responses., PMID:36368593
Integrative weighted molecular network construction from transcriptomics and genome wide association data to identify shared genetic biomarkers for COPD and lung cancer., PMID:36194576
Polygenic Innate Immunity Score to Predict the Risk of Cytomegalovirus Infection in CMV D+/R- Transplant Recipients. A Prospective Multicenter Cohort Study., PMID:36016941
Intergrated Transcriptomic and Proteomic Analysis Revealed the Differential Responses to Novel Duck Reovirus Infection in the Bursa of Fabricius of Cairna moschata., PMID:35893682
Pacritinib Inhibition of IRAK1 Blocks Aberrant TLR8 Signalling by SARS-CoV-2 and HIV-1-Derived RNA., PMID:35785771
Multi-locus SNP analyses of interleukin 1 receptor associated kinases 2 gene polymorphisms with the susceptibility to rheumatoid arthritis., PMID:35588430
Implication of genetic variants in primary microRNA processing sites in the risk of multiple sclerosis., PMID:35561450
Purification, crystallization and drug screening of the IRAK pseudokinases., PMID:35525539
IRAK2-NF-κB signaling promotes glycolysis-dependent tumor growth in pancreatic cancer., PMID:35486320
Natural Plant Compounds: Does Caffeine, Dipotassium Glycyrrhizinate, Curcumin, and Euphol Play Roles as Antitumoral Compounds in Glioblastoma Cell Lines?, PMID:35300350
A CD40 variant is associated with systemic bone loss among patients with rheumatoid arthritis., PMID:35107652
miR-424-5p overexpression inhibits LPS-stimulated inflammatory response in bovine endometrial epithelial cells by targeting IRAK2., PMID:35032930
A Random Walk-Based Method to Identify Candidate Genes Associated With Lymphoma., PMID:34899868
Structural anomalies in a published NMR-derived structure of IRAK-M., PMID:34837785
IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies., PMID:34743084
HOIL-1-catalysed, ester-linked ubiquitylation restricts IL-18 signaling in cytotoxic T cells but promotes TLR signalling in macrophages., PMID:33932090
IRAK2 Has a Critical Role in Promoting Feed-Forward Amplification of Epidermal Inflammatory Responses., PMID:33864770
The extreme C-terminus of IRAK2 assures full TRAF6 ubiquitination and optimal TLR signaling., PMID:33799071
Role of the Host Genetic Susceptibility to 2009 Pandemic Influenza A H1N1., PMID:33671828
Manganese superoxide dismutase induced by lipoteichoic acid isolated from Staphylococcus aureus regulates cytokine production in THP-1 cells., PMID:33558048
Protein Kinase-Mediated Decision Between the Life and Death., PMID:33539010
For research use only. Not for human or drug use.
