Catalog No.
YHA59901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val31-His350
Predicted molecular weight
38.27 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43184
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ADAM 12, MLTN, Meltrin-alpha, Disintegrin and metalloproteinase domain-containing protein 12, ADAM12
ADAM12 promotes temozolomide resistance in glioblastoma by activating the TNF-α - NF-κB pathway., PMID:40180114
MeCP2 promotes keloid progression by regulating ADAM12 expression and Wnt/β-catenin pathway., PMID:40119949
Pan-cancer analysis identifies ADAM12 as a prognostic biomarker and indicator of immune infiltration in glioma., PMID:39984619
Molecular mechanisms of recombinant proteins PTTG1IP, ADAM12, PAPSS1, and MYO1B and their effects on wound repair induced by tendon exposure: Analysis of key genes., PMID:39978508
Profiling the Secretome of Glioblastoma Cells Under Histone Deacetylase Inhibition Using Mass Spectrometry., PMID:39959291
Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1., PMID:39806854
A disintegrin and metallopeptidase domain (ADAM) 12, ADAM 17 mRNA and ADAM10 protein hold potential as biomarkers for detection of early gastric cancer., PMID:39755747
Unveiling miRNA30b's Role in Suppressing ADAM12 to Combat Triple-Negative Breast Cancer., PMID:39742357
Are hypoxia-related proteins associated with the invasiveness of glandular odontogenic cysts? A multicenter study., PMID:39644628
Genes Related to Motility in an Ionizing Radiation and Estrogen Breast Cancer Model., PMID:39596804
Identification of Potential Biomarkers and Therapeutic Targets for Periodontitis., PMID:39532570
From inflammation to depression: key biomarkers for IBD-related major depressive disorder., PMID:39501335
Fibrolytic vaccination against ADAM12 reduces desmoplasia in preclinical pancreatic adenocarcinomas., PMID:39478152
HLA-G neo-expression modifies genetic programs governing tumor cell lines., PMID:39358558
Embryo-Derived Cathepsin B Promotes Implantation and Decidualization by Activating Pyroptosis., PMID:39316370
Fibrosis uncovered: ADAMTS12 cuts to the core of extracellular matrix drama., PMID:39286974
Serum cytokine profiles in children with IgA vasculitis with nephritis., PMID:39235446
Circadian clock component PER2 negatively regulates CD4+ T cell IFN-γ production in ulcerative colitis., PMID:39097147
ADAM12-Generated Basigin Ectodomain Binds β1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins., PMID:38892056
Disturbance of Fetal Growth by Azithromycin Through Induction of ER Stress in the Placenta., PMID:38877798
The Emerging Role of ADAM 12 Regulates Epithelial-mesenchymal Transition by Activating the Wnt/β-catenin Signaling Pathway in Colorectal Cancer., PMID:38716545
Exploring the ADAM12 Expression in Clear Cell Renal Cell Carcinoma: A Radiogenomic Analysis on CT Imaging., PMID:38485610
Epigenetic Mechanisms Histone Deacetylase-Dependent Regulate the Glioblastoma Angiogenic Matrisome and Disrupt Endothelial Cell Behavior In Vitro., PMID:38272115
Amplifying T cell-mediated antitumor immune responses in nonsmall cell lung cancer through photodynamic therapy and anti-PD1., PMID:38269509
Polymorphism of ADAM12, DPP6 and PRKN genes and their associations with milk production traits in Holstein., PMID:37917556
MiR-135b-5p targets ADAM12 to suppress invasion and accelerate trophoblast apoptosis in preeclampsia., PMID:37864886
A new strategy to identify ADAM12 and PDGFRB as a novel prognostic biomarker for matrine regulates gastric cancer via high throughput chip mining and computational verification., PMID:37847945
Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis., PMID:37798557
Prognostic Impact of FSTL3, ADAM12, and FAT4 in Patients of Colon Cancer: Clinicopathologic Study., PMID:37751246
Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy., PMID:37715129
ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy., PMID:37495855
ADAM12 promotes the resistance of lung adenocarcinoma cells to EGFR-TKI and regulates the immune microenvironment by activating PI3K/Akt/mTOR and RAS signaling pathways., PMID:37418984
Genetic Associations with Placental Proteins in Maternal Serum Identify Biomarkers for Hypertension in Pregnancy., PMID:37398343
PRDM16 deficiency in vascular smooth muscle cells aggravates abdominal aortic aneurysm., PMID:37079380
Upregulation of Cell Surface Glycoproteins in Correlation with KSHV LANA in the Kaposi Sarcoma Tumor Microenvironment., PMID:37046832
A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition., PMID:36866761
The association between ADAM12 gene polymorphisms and osteoarthritis: an updated meta-analysis., PMID:36855121
ADAM Metallopeptidase Domain 12 Facilitates Colorectal Cancer Progression by Inhibiting Hippo Signaling Pathway Activity., PMID:36806444
ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway., PMID:36717944
Validation of a multiple marker test for early pregnancy outcome prediction., PMID:36708430
Alternatively Spliced Isoforms of MUC4 and ADAM12 as Biomarkers for Colorectal Cancer Metastasis., PMID:36675796
ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer., PMID:36545255
MicroRNA-149 Regulates Proliferation, Migration, and Invasion of Pituitary Adenoma Cells by Targeting ADAM12 and MMP14., PMID:36542326
ADAM12 promotes gemcitabine resistance by activating EGFR signaling pathway and induces EMT in bladder cancer., PMID:36512304
Effects of Subtoxic Concentrations of Atrazine, Cypermethrin, and Vinclozolin on microRNA-Mediated PI3K/Akt/mTOR Signaling in SH-SY5Y Cells., PMID:36498866
Identification of the circRNA-miRNA-mRNA Regulatory Network in Pterygium-Associated Conjunctival Epithelium., PMID:36398070
Roles of follistatin-like protein 3 in human non-tumor pathophysiologies and cancers., PMID:36325361
Serum ADAM metallopeptidase domain 12 as a promising diagnostic biomarker for breast and liver cancer., PMID:36183312
Vaccination-based immunotherapy to target profibrotic cells in liver and lung., PMID:36113462
Expression of ADAM12 in Gastric Cancer and its Relation to Tumor Cell Behavior and Prognosis., PMID:36099146
For research use only. Not for human or drug use.
