Catalog No.
YHA56301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys83-Ala338
Predicted molecular weight
31.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15530
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PDK1, hPDK1, PDPK1, 3-phosphoinositide-dependent protein kinase 1
Investigating the impact of camel whey protein hydrolysate on cyp1a1 and keap1/nrf2 expression in hypoxic stress-affected liver tissue of Oreochromis niloticus., PMID:40493086
FHL2 Facilitates LUSC Growth and Therapy Resistance through PI3K/AKT/mTOR Activation., PMID:40482916
Mechanism Analysis of Zuogui and Yougui Pills on Diabetic Nephropathy Through Transcriptional Regulatory Networks of HIF1A and PPARA., PMID:40417738
Astrocytes-derived LCN2 triggers EV-A71-induced muscle soreness via accumulating lactate., PMID:40378229
7,7-Bis(3-Indolyl)-p-Cresol, a Metabolite from Marine-Derived Bacterium Vibrio spp. DJA11, Suppresses the Proliferation and Motility of Prostate Cancer Cells., PMID:40374533
Examination of PDK1/AKT/mTOR transcription and exosomal mRNA levels in human glioblastoma cell line treated with a combination of temozolomide and hesperidin., PMID:40372477
Anticancer Potential of Cymbopogon citratus L. Essential Oil: In Vitro and In Silico Insights into Mitochondrial Dysfunction and Cytotoxicity in Cancer Cells., PMID:40364370
Integrating Bioinformatics and Machine Learning to Identify Glucose Metabolism-Related Biomarkers with Diagnostic and Prognostic Value for Patients with Kidney Renal Clear Cell Carcinoma., PMID:40341002
Target Validation Studies of PS48, a PDK-1 Allosteric Agonist, for the Treatment of Alzheimer's Disease Phenotype in APP/PS1 Transgenic Mice., PMID:40331945
Mitochondria-targeting natural product rhein conjugated with dichloroacetate as the dual inhibitor of glycolysis and oxidative phosphorylation to off energize cancer cells and induce ROS storm., PMID:40303329
EMC2 promotes breast cancer progression and enhances sensitivity to PDK1/AKT inhibition by deubiquitinating ENO1., PMID:40303285
Resveratrol inhibits the progression of oral squamouscell carcinoma through Norad/Igf2bp2/Pdk1 pathway and remodeling glucose metabolism reprogramming., PMID:40272637
The ultrafine powder of atractylodis macrocephalae rhizoma improves immune function in naturally aging rats by regulating the PI3K/Akt/NF-κB signaling pathway., PMID:40255567
Uncovering the Role of Distal Regions in PDK1 Allosteric Activation., PMID:40255282
USP7 promotes endothelial activation to aggravate sepsis-induced acute lung injury through PDK1/AKT/NF-κB signaling pathway., PMID:40246841
Mechanical Force Triggers Macrophage Pyroptosis and Sterile Inflammation by Disrupting Cellular Energy Metabolism., PMID:40244158
Impaired cardiac branched-chain amino acid metabolism in a novel model of diabetic cardiomyopathy., PMID:40240904
Low level of lactate and trophoblast dysfunction mediated by SNAI1/PDK1 contributes to miscarriage., PMID:40187272
Combining network pharmacology and transcriptomics to validate and explore the efficacy and mechanism of Huayu Wan in treating non-small cell lung cancer., PMID:40185258
SIRT5 Inhibits Mitophagy and Inflammation of Hypoxia-Induced Pulmonary Hypertension by Regulating the Desuccinylation of PDK1., PMID:40169475
An HRL-SC/HIF-1α positive feedback loop enhances cell proliferation, migration and angiogenesis in dental pulp stem cells via PI3K/AKT signalling pathway., PMID:40152548
Genome-Wide Analysis of AGC Genes Related to Salt Stress in Soybeans (Glycine max)., PMID:40141228
Orlistat facilitates immunotherapy via AKT-FOXO3a-FOXM1-mediated PD-L1 suppression., PMID:40139835
Knockdown of SLC7A5 inhibits malignant progression and attenuates oxaliplatin resistance in gastric cancer by suppressing glycolysis., PMID:40133832
Gua Sha Alleviates Radiculitis-Induced Pain Via HIF-1α-Mediated Metabolic Reprogramming Pathway in Rats., PMID:40130025
308-nm excimer laser combined with piperine promotes melanin synthesis through PTEN/PDK1/GSK3b regulation of keratinocyte paracrine., PMID:40105984
Complement C3a promotes the formation of osteoclasts by inhibiting Sirt1 to activate the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma., PMID:40091033
Sinomenine synergistically enhances 5-Fu anticancer effects in oral cancer through modulating the miR-140-5p-PDK1-anaerobic glycolysis pathway., PMID:40086584
Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes., PMID:40074083
Melatonin attenuates inflammatory bone loss by alleviating mitophagy and lactate production., PMID:40064756
Hypoxia inducible factor-1α drives cancer resistance to cuproptosis., PMID:40054467
Anthocyanin-Binding Affinity and Non-Covalent Interactions with IIS-Pathway-Related Protein Through Molecular Docking., PMID:39996808
[Partial knockout of NtPDK1a/1b/1c/1d enhances the disease resistance of Nicotiana tabacum]., PMID:39989063
PDK1-mediated phosphorylation of USP5 modulates NF-κB signalling to enhance osteosarcoma growth., PMID:39988167
Lactoferrin-encapsulated dichloroacetophenone (DAP) nanoparticles enhance drug delivery and anti-tumor efficacy in prostate cancer., PMID:39924080
The m6A modification regulates the composition of myofiber types in chicken skeletal muscle., PMID:39919566
Molecular Docking Appraisal of Pleurotus ostreatus Phytochemicals as Potential Inhibitors of PI3K/Akt Pathway for Breast Cancer Treatment., PMID:39906062
A cellular model of TDP-43 induces phosphorylated TDP-43 aggregation with distinct changes in solubility and autophagy dysregulation., PMID:39887552
miR378a-3p in serum extracellular vesicles is associated with pancreatic beta-cell mass in diabetic states., PMID:39879698
Lactoferrin conjugated radicicol nanoparticles enhanced drug delivery and cytotoxicity in prostate cancer cells., PMID:39870236
Investigating the link between microplastic exposure (benzyl butyl phthalate) and neurodegenerative diseases using high-performance computational toxicology., PMID:39830890
Ribosomal s6 kinase is a mediator of aquaporin-2 S256 phosphorylation and membrane accumulation after EGFR inhibition with erlotinib., PMID:39823198
An in-depth study of indolone derivatives as potential lung cancer treatment., PMID:39820391
Role of PI3K/AKT signaling pathway during capacitation., PMID:39799846
Generation of a PDK-1 knockout human embryonic stem cell line by CRISPR/(WAe009-A-2K) Cas9 editing., PMID:39798272
In vivo antitumor activity of PHT-427 inhibitor-loaded polymeric nanoparticles in head and neck squamous cell carcinoma., PMID:39789884
Activation of the WNT4/ β-catenin/FOXO1 pathway by PDK1 promotes cervical cancer metastasis and EMT process., PMID:39779500
Distinct UPR and Autophagic Functions Define Cell-Specific Responses to Proteotoxic Stress in Microglial and Neuronal Cell Lines., PMID:39768160
Investigation of the protective effect of cilostazol on acute lung injury-mediated inflammation and in silico molecular modelling studies of inflammatory signalling pathway: a repurposing study., PMID:39754679
Shikonin induces the apoptosis and pyroptosis of EGFR-T790M-mutant drug-resistant non-small cell lung cancer cells via the degradation of cyclooxygenase-2., PMID:39702296
For research use only. Not for human or drug use.
