Catalog No.
YHA54601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu32-Asp165
Predicted molecular weight
17.32 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15496
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Group 10 secretory phospholipase A2, PLA2G10, Phosphatidylcholine 2-acylhydrolase 10, sPLA2-X, GX sPLA2, Group X secretory phospholipase A2
Intestinal overexpression of Pla2g10 alters the composition, diversity and function of gut microbiota in mice., PMID:40160470
Group X phospholipase A2 links colonic lipid homeostasis to systemic metabolism via host-microbiota interaction., PMID:39298315
Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity., PMID:38669316
Exploring biomarkers in trigeminal neuralgia patients operated with microvascular decompression: A comparison with multiple sclerosis patients and non-neurological controls., PMID:38158702
Combination of metabolomics and network pharmacology analysis to decipher the mechanisms of total flavonoids of Litchi seed against prostate cancer., PMID:37167442
Cellular Distribution of Secreted Phospholipase A2 in Lungs of IPF Patients and Its Inhibition in Bleomycin-Induced Pulmonary Fibrosis in Mice., PMID:37048117
Multi-omics profiling of PC-3 cells reveals bufadienolides-induced lipid metabolic remodeling by regulating long-chain lipids synthesis and hydrolysis., PMID:36645548
Dengue NS1 induces phospholipase A2 enzyme activity, prostaglandins, and inflammatory cytokines in monocytes., PMID:35395274
Understanding the role of myoglobin content in Iberian pigs fattened in an extensive system through analysis of the transcriptome profile., PMID:35355298
PLA2G10 incorporated in exosomes could be diagnostic and prognostic biomarker for non-small cell lung cancer., PMID:35231479
Exercise-induced alterations in phospholipid hydrolysis, airway surfactant, and eicosanoids and their role in airway hyperresponsiveness in asthma., PMID:33533300
Mating to Intact, but Not Vasectomized, Males Elicits Changes in the Endometrial Transcriptome: Insights From the Bovine Model., PMID:32766237
PLA2G10 facilitates the cell-cycle progression of soft tissue leiomyosarcoma cells at least by elevating cyclin E1/CDK2 expression., PMID:32423798
Secreted Phospholipase A2 Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung., PMID:32341057
Wide-Range Effects of 1,25(OH)2D3 on Group 4A Phospholipases Is Related to Nuclear Factor κ-B and Phospholipase-A2 Activating Protein Activity in Mast Cells., PMID:31707382
Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen., PMID:29093264
Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer., PMID:27292189
Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility., PMID:26828067
Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils., PMID:26139511
Deficiency of spermatogenesis and reduced expression of spermatogenesis-related genes in prefoldin 5-mutant mice., PMID:29124133
PLA2G10 Gene Variants, sPLA2 Activity, and Coronary Heart Disease Risk., PMID:25583995
Phylogenetic and structural analysis of the phospholipase A2 gene family in vertebrates., PMID:25543670
The effect of group X secreted phospholipase A2 on fertilization outcome is specific and not mimicked by other secreted phospholipases A2 or progesterone., PMID:24287291
Deficiency of phospholipase A2 receptor exacerbates ovalbumin-induced lung inflammation., PMID:23817419
Regulation and function of epithelial secreted phospholipase A2 group X in asthma., PMID:23614662
Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice., PMID:23349189
Human group X secreted phospholipase A2 induces dendritic cell maturation through lipoprotein-dependent and -independent mechanisms., PMID:22494626
Group X secretory PLA2 in neutrophils plays a pathogenic role in abdominal aortic aneurysms in mice., PMID:21984544
Group X secreted phospholipase A₂ specifically decreases sperm motility in mice., PMID:21792918
Blockade of human group X secreted phospholipase A2 (GX-sPLA2)-induced airway inflammation and hyperresponsiveness in a mouse asthma model by a selective GX-sPLA2 inhibitor., PMID:21652694
Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X., PMID:20974857
Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice., PMID:20833395
Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis., PMID:18801741
Enhanced protein expression in mammalian cells using engineered SUMO fusions: secreted phospholipase A2., PMID:18539905
Reduction in myocardial ischemia/reperfusion injury in group X secretory phospholipase A2-deficient mice., PMID:18506007
Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate., PMID:18212756
Identification of differential expression of genes in hepatocellular carcinoma by suppression subtractive hybridization combined cDNA microarray., PMID:17786358
Butyrate inhibits oral cancer cell proliferation and regulates expression of secretory phospholipase A2-X and COX-2., PMID:17595767
Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model., PMID:17403936
Differential behavior of sPLA2-V and sPLA2-X in human neutrophils., PMID:17275398
Hydrolysis of minor glycerophospholipids of plasma lipoproteins by human group IIA, V and X secretory phospholipases A2., PMID:17197234
Modulation of the activity and arachidonic acid selectivity of group X secretory phospholipase A2 by sphingolipids., PMID:17148553
Atherogenic properties of LDL particles modified by human group X secreted phospholipase A2 on human endothelial cell function., PMID:17077289
Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction., PMID:17008322
The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2., PMID:16962371
The first potent inhibitor of mammalian group X secreted phospholipase A2: elucidation of sites for enhanced binding., PMID:16686528
sPLA2-X stimulates cutaneous melanocyte dendricity and pigmentation through a lysophosphatidylcholine-dependent mechanism., PMID:16456529
Diverse cellular localizations of secretory phospholipase A2 enzymes in several human tissues., PMID:16188494
Synergy between extracellular group IIA phospholipase A2 and phagocyte NADPH oxidase in digestion of phospholipids of Staphylococcus aureus ingested by human neutrophils., PMID:16177112
Group V and X secretory phospholipase A2 prevents adenoviral infection in mammalian cells., PMID:16146426
For research use only. Not for human or drug use.
