Catalog No.
YHA52901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile1041-Gln1274
Predicted molecular weight
28.85 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15439
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MOAT-B, MOATB, Multi-specific organic anion transporter B, ATP-binding cassette sub-family C member 4, Multidrug resistance-associated protein 4, MRP4, ABCC4, MRP/cMOAT-related ABC transporter
Pharmacogenetic Profiling of Genes Associated with Outcomes of Chemotherapy in Omani Healthy Controls., PMID:40428413
In vitro assessment of ATP-binding cassette transporters and their functional genetic polymorphisms on fluoroquinolone accumulation in human embryonic kidney 293 recombinant cell lines., PMID:40253817
Exploring the Molecular Intersection of Posterior Ocular Tuberculosis: Mycobacterium tuberculosis Proteins, Ocular Autoimmunity, and Immune Receptor Interactions., PMID:40151358
Structural basis of human ABCC4 recognition of cAMP and ligand recognition flexibility., PMID:40148998
Molecular determinants of neuroprotection in blood-brain interfaces of the cynomolgus monkey., PMID:40144668
Structural basis for the reversal of human MRP4-mediated multidrug resistance by lapatinib., PMID:40138312
Rapid Evolution in Action: Environmental Filtering Supports Coral Adaptation to a Hot, Acidic, and Deoxygenated Extreme Habitat., PMID:40028829
Genome-Wide Association Studies for Lactation Performance in Buffaloes., PMID:40004492
Silencing drug transporters in human primary muscle cells modulates atorvastatin pharmacokinetics: A pilot study., PMID:39909477
The Role of Candidate Polymorphisms in Drug Transporter Genes on High-Dose Methotrexate in the Consolidation Phase of the AIEOP-BFM ALL 2009 Protocol., PMID:39891427
Characterisation of pregnancy-induced alterations in apolipoproteins and their associations with maternal metabolic risk factors and offspring birth outcomes: a preconception and longitudinal cohort study., PMID:39842285
Protective role of ABCC drug subfamily resistance transporters (ABCC1-7) in intestinal inflammation., PMID:39808251
Knockdown of an ATP-binding cassette transporter in resistant western corn rootworm larvae partially reverses resistance to eCry3.1Ab protein., PMID:39733129
The cytokinin efflux transporter ABCC4 participates in Arabidopsis root system development., PMID:39719052
Investigating the crosstalk between ABCC4 and ABCC5 in 3T3-L1 adipocyte differentiation., PMID:39717760
Identification of Genetic Factors Related With Nonhereditary Colorectal Polyposis and Its Recurrence Through Genome-Wide Association Study., PMID:39629711
Upregulation of P-Glycoprotein and Breast Cancer Resistance Protein Activity in Newly Developed in Vitro Rat Blood-Brain Barrier Spheroids Using Advanced Glycation End-Products., PMID:39551527
Circular RNA circABCC4 as the ceRNA facilitates renal carcinoma progression., PMID:39475972
Enhanced platelet sensitization is accompanied by increased expression of the transporter MRP4 and elevated plasma S1P levels in mild COVID-19 convalescents., PMID:39475058
Obesity-related drug transporter expression alterations in human liver and kidneys., PMID:39412582
Flurbiprofen inhibits cAMP transport by MRP4/ABCC4 increasing the potency of gemcitabine treatment in PDAC cell models., PMID:39378921
Analysis of CNS autoimmunity in genetically diverse mice reveals unique phenotypes and mechanisms., PMID:39325545
Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites., PMID:39313329
Organic anion transporters in remote sensing and organ crosstalk., PMID:39284369
Tumor ABCC4-mediated release of PGE2 induces CD8+ T cell dysfunction and impairs PD-1 blockade in prostate cancer., PMID:39247809
Studies on absorption mechanism and pharmacokinetic properties of albendazole-bile acid conjugate: In vivo and in vitro., PMID:39243427
Evaluation of Novel Diaza Cage Compounds as MRP Modulators in Cancer Cells., PMID:39219427
Association of rare and common genetic variants in MOCOS with inadequate response to allopurinol., PMID:39137147
Overcoming flumatinib resistance in chronic myeloid leukaemia: Insights into cellular mechanisms and ivermectin's therapeutic potential., PMID:39046364
Ticagrelor modestly raises plasma riboflavin concentration in humans and inhibits riboflavin transport by BCRP and MRP4., PMID:39039844
Antiretroviral drug dolutegravir induces inflammation at the mouse brain barriers., PMID:38982638
Effect of hypoxia on aquaporins and hepatobiliary transport systems in human hepatic cells., PMID:38951656
Caffeine Inhibits Both Basal and Insulin-Activated Urate Transport., PMID:38932509
Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells., PMID:38905201
The ATP-bound inward-open conformation of ABCC4 reveals asymmetric ATP binding for substrate transport., PMID:38886124
The multidrug resistance protein 4 is expressed and functionally active in isolated bladder from pig., PMID:38881411
Transporter Protein Expression of Corneal Epithelium in Rabbit and Porcine: Evaluation of Models for Ocular Drug Transport Study., PMID:38809137
Distinguishing Molecular Properties of OAT, OATP, and MRP Drug Substrates by Machine Learning., PMID:38794254
Pharmacogenetics of tenofovir drug transporters in the context of HBV: Is there an impact?, PMID:38713940
Factors Influencing Mortality in Children with Central Nervous System Tumors: A Cohort Study on Clinical Characteristics and Genetic Markers., PMID:38674407
Utilization of Diverse Molecules as Receptors by Cry Toxin and the Promiscuous Nature of Receptor-Binding Sites Which Accounts for the Diversity., PMID:38672442
Unraveling the genetics of arsenic toxicity with cellular morphology QTL., PMID:38662777
Epigenetic dissection of human blood group genes reveals regulatory elements and detailed characteristics of KEL and four other loci., PMID:38644556
Identification of ADME genes polymorphic variants linked to trastuzumab-induced cardiotoxicity in breast cancer patients: Case series of mono-institutional experience., PMID:38547766
Comparing ATPase activity of ATP-binding cassette subfamily C member 4, lamprey CFTR, and human CFTR using an antimony-phosphomolybdate assay., PMID:38440176
Structural View of Cryo-Electron Microscopy-Determined ATP-Binding Cassette Transporters in Human Multidrug Resistance., PMID:38397468
ABCC4 suppresses glioblastoma progression and recurrence by restraining cGMP-PKG signalling., PMID:38347095
Atorvastatin-associated myotoxicity: A toxicokinetic review of pharmacogenetic associations to evaluate the feasibility of precision pharmacotherapy., PMID:38182100
Cranberry Proanthocyanidins Mitigate Reflux-Induced Transporter Dysregulation in an Esophageal Adenocarcinoma Model., PMID:38139823
Characteristics of ABCC4 and ABCG2 High Expression Subpopulations in CRC-A New Opportunity to Predict Therapy Response., PMID:38067326