Catalog No.
YHA51101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala107-Val392
Predicted molecular weight
34.67 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15382
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BCT2, BCAT2, BCAT(m), BCATM, Placental protein 18, Branched-chain-amino-acid aminotransferase, mitochondrial, PP18, ECA40
Integrating machine learning and molecular docking to decipher the molecular network of aflatoxin b1-induced hepatocellular carcinoma., PMID:40392001
Combined network pharmacology and metabolomics reveal that Rubia cordifolia L. ameliorates exhaustive exercise-induced myocardial injury in rats via the BCAA degradation pathway., PMID:40378926
BCAT2 binding to PCBP1 regulates the PI3K/AKT signaling pathway to inhibit autophagy-related apoptosis and ferroptosis in prostate cancer., PMID:40274762
Spatial Metabolomics and Transcriptomics Reveal Metabolic Reprogramming and Cellular Interactions in Nasopharyngeal Carcinoma with High PD-1 Expression and Therapeutic Response., PMID:40083932
BCAT2 Expression in IDC Breast Cancer subtypes: A Weighted Feature-Based Approach to Identify and Rank Associated Genes Across Public Datasets., PMID:40039929
Design, Synthesis and Biological Activity Study of γ-Aminobutyric Acid (GABA) Derivatives Containing Bridged Bicyclic Skeletons as BCAT1 Inhibitors., PMID:40005214
Gut Microbiota-Mediated hsa_circ_0126925 Targets BCAA Metabolic Enzyme BCAT2 to Exacerbate Colorectal Cancer Progression., PMID:39642324
Oligonol®, an Oligomerized Polyphenol from Litchi chinensis, Enhances Branched-Chain Amino Acid Transportation and Catabolism to Alleviate Sarcopenia., PMID:39519101
Notch1 blockade by a novel, selective anti-Notch1 neutralizing antibody improves immunotherapy efficacy in melanoma by promoting an inflamed TME., PMID:39491031
Identification of New Single Nucleotide Polymorphisms Potentially Related to Small Ruminant Lentivirus Infection Susceptibility in Goats Based on Data Selected from High-Throughput Sequencing., PMID:39452702
Multi-omics analysis identifies BCAT2 as a potential pan-cancer biomarker for tumor progression and immune microenvironment modulation., PMID:39375392
Widely Untargeted Metabolomics Profiling Combined with Transcriptome Analysis Provides New Insight into Amino Acid Biosynthesis at Different Developmental Stages of Rubus Chingii Hu (Chinese Raspberry)., PMID:39254678
Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers., PMID:39242942
Low storage temperature affects quality and volatile compounds in fresh tomatoes., PMID:39033633
Transcriptomic and histologic analyses preliminarily reveal the immune-metabolic response mechanism to saline-alkaline in large yellow croaker (Larimichthys crocea)., PMID:38943980
Adipocytes Are the Only Site of Glutamine Synthetase Expression Within the Lactating Mouse Mammary Gland., PMID:38813479
Bcat2-Mediated Branched-Chain Amino Acid Catabolism Is Linked to the Aggravated Inflammation in Obese with Psoriasis Mice., PMID:38581348
miR-743b-3p promotes hepatic lipogenesis via branched-chain amino acids (BCAA) metabolism by targeting PPM1K in aged mice., PMID:38565071
Multiple-matrices metabolomics combined with serum pharmacochemistry for discovering the potential targets and active constituents of Qifu decoction against heart failure., PMID:38522367
Plasma Proteome-Wide Mendelian Randomization Analysis Reveals Biomarkers and Therapeutic Targets for Different Stages of COVID-19., PMID:40303168
Maintenance of the branched-chain amino acid transporter LAT1 counteracts myotube atrophy following chemotherapy., PMID:38284122
Metabolic Pathway Engineering Improves Dendrobine Production in Dendrobium catenatum., PMID:38203567
Genipin inhibits proliferation of gastric cancer cells by inducing ferroptosis: an integrated study of network pharmacology and bioinformatics study., PMID:38175425
Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis., PMID:37993768
Deficiency of BCAT2-mediated branched-chain amino acid catabolism promotes colorectal cancer development., PMID:37926361
Gene purging and the evolution of Neoave metabolism and longevity., PMID:37918802
Identification of ferroptosis-related genes in type 2 diabetes mellitus based on machine learning., PMID:37904700
BCAT2 promotes melanoma progression by activating lipogenesis via the epigenetic regulation of FASN and ACLY expressions., PMID:37801083
Branched-chain amino acid supplementation does not enhance lean tissue accretion in low birth weight neonatal pigs, despite lower Sestrin2 expression in skeletal muscle., PMID:37743429
Comprehensive analysis of ferritinophagy-related genes and immune infiltration landscape in diabetic retinopathy., PMID:37522124
Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression., PMID:37337119
High doses of rosuvastatin induce impaired branched-chain amino acid catabolism and lead to insulin resistance., PMID:37139700
Prenatal Exposure to Metabolism-Disrupting Chemicals, Cord Blood Transcriptome Perturbations, and Birth Weight in a Belgian Birth Cohort., PMID:37108768
Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma., PMID:37076565
Bcat1 is controlled by Tsc2/mTORC1 pathway at expression levels and its deficiency together with Bcat2 inactivation suppresses the growth of a Tsc2-/- tumor cell line., PMID:36965015
Hepatic and serum branched-chain fatty acid profile in patients with nonalcoholic fatty liver disease: A case-control study., PMID:36876627
BCAT2 Shapes a Noninflamed Tumor Microenvironment and Induces Resistance to Anti-PD-1/PD-L1 Immunotherapy by Negatively Regulating Proinflammatory Chemokines and Anticancer Immunity., PMID:36642843
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism., PMID:36608679
Metabolic Adaptations and Substrate Oxidation are Unaffected by Exogenous Testosterone Administration during Energy Deficit in Men., PMID:36563086
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis., PMID:36443523
Distribution characteristics and regulation of amino acids and fatty acids in muscle and adipose tissues of sheep grown in natural grazing environment., PMID:36127314
The mechanism of branched-chain amino acid transferases in different diseases: Research progress and future prospects., PMID:36119495
Plasma proteomics of SARS-CoV-2 infection and severity reveals impact on Alzheimer and coronary disease pathways., PMID:35923315
Enhancement of BCAT2-Mediated Valine Catabolism Stimulates β-Casein Synthesis via the AMPK-mTOR Signaling Axis in Bovine Mammary Epithelial Cells., PMID:35916279
Acute binge alcohol alters whole body metabolism and the time-dependent expression of skeletal muscle-specific metabolic markers for multiple days in mice., PMID:35793479
Diet high in branched-chain amino acid promotes PDAC development by USP1-mediated BCAT2 stabilization., PMID:35663242
Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma., PMID:35499760
The BCAT1 CXXC Motif Provides Protection against ROS in Acute Myeloid Leukaemia Cells., PMID:35453368
Identification of 14 Differentially-Expressed Metabolism-Related Genes as Potential Targets of Gastric Cancer by Integrated Proteomics and Transcriptomics., PMID:35265615
Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients., PMID:35178660
For research use only. Not for human or drug use.
