Catalog No.
YHA34701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln8-His258
Predicted molecular weight
30.51 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14926
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Fascin-2, Retinal fascin, FSCN2
Inhibition of the ILK-AKT pathway by upregulation of PARVB contributes to the cochlear cell death in Fascin2 gene knockout mice., PMID:38374196
RNA-seq analysis highlights DNA replication and DNA repair associated with early-onset hearing loss in the cochlea of DBA/2J mice., PMID:38103727
Comprehensive analysis of the expression, prognosis and biological significance of FSCN family in clear cell renal cell carcinoma., PMID:37559574
Mediation by DNA methylation on the association of BMI and serum uric acid in Chinese monozygotic twins., PMID:36243213
Population-scale analysis of common and rare genetic variation associated with hearing loss in adults., PMID:35661827
Retinitis pigmentosa-linked mutation in DHX38 modulates its splicing activity., PMID:35385551
Prognostic significance of FSCN family in multiple myeloma., PMID:33753991
Pristine Cu-MOF Induces Mitotic Catastrophe and Alterations of Gene Expression and Cytoskeleton in Ovarian Cancer Cells., PMID:35025483
Identification of ncRNA-Mediated Functions of Nucleus-Localized miR-320 in Cardiomyocytes., PMID:31837603
PRPF31 reduction causes mis-splicing of the phototransduction genes in human organotypic retinal culture., PMID:31654038
Null Mutation of the Fascin2 Gene by TALEN Leading to Progressive Hearing Loss and Retinal Degeneration in C57BL/6J Mice., PMID:30082328
Human organotypic retinal flat-mount culture (HORFC) as a model for retinitis pigmentosa11., PMID:29744916
NOVEL CONE DYSTROPHY WITH CENTRAL ELLIPSOID ZONE LOSS ASSOCIATED WITH HUMAN RETINAL FASCIN GENE (FSCN2) MUTATION., PMID:29016529
Targeted RP9 ablation and mutagenesis in mouse photoreceptor cells by CRISPR-Cas9., PMID:28216641
Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid., PMID:27811163
A QTL on Chr 5 modifies hearing loss associated with the fascin-2 variant of DBA/2J mice., PMID:26092689
Attenuation of hearing loss in DBA/2J mice by anti-apoptotic treatment., PMID:26003529
[Genotype-phenotype correlation in patients with PRPH2-mutations]., PMID:25803555
Quantitative trait loci on chromosome 5 for susceptibility to frequency-specific effects on hearing in DBA/2J mice., PMID:25765874
Gene profiling of postnatal Mfrprd6 mutant eyes reveals differential accumulation of Prss56, visual cycle and phototransduction mRNAs., PMID:25357075
Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea., PMID:24845860
Whole exome sequencing in Thai patients with retinitis pigmentosa reveals novel mutations in six genes., PMID:24618324
Correlation of actin crosslinker and capper expression levels with stereocilia growth phases., PMID:24319057
The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice., PMID:20660251
[Genetic aspects of age-related macular degeneration]., PMID:19673454
Allelic copy number variation in FSCN2 detected using allele-specific genotyping and multiplex real-time PCRs., PMID:18450588
A high-resolution RNA expression atlas of retinitis pigmentosa genes in human and mouse retinas., PMID:18281612
Identification of photoreceptor genes affected by PRPF31 mutations associated with autosomal dominant retinitis pigmentosa., PMID:17350276
Retina-specific protein fascin 2 is an actin cross-linker associated with actin bundles in photoreceptor inner segments and calycal processes., PMID:17325187
The 208delG mutation in FSCN2 does not associate with retinal degeneration in Chinese individuals., PMID:17251446
The retinal fascin gene 2 (FSCN2)--partial structural analysis and polymorphism detection in dogs with progressive retinal atrophy (PRA)., PMID:17132901
Prevalence of disease-causing mutations in families with autosomal dominant retinitis pigmentosa: a screen of known genes in 200 families., PMID:16799052
Sequence variations in the retinal fascin FSCN2 gene in a Spanish population with autosomal dominant retinitis pigmentosa or macular degeneration., PMID:16280978
Targeted disruption of FSCN2 gene induces retinopathy in mice., PMID:16043865
Molecular genetics of autosomal dominant retinitis pigmentosa (ADRP): a comprehensive study of 43 Italian families., PMID:15994872
Autosomal dominant macular degeneration associated with 208delG mutation in the FSCN2 gene., PMID:14609921
Mutation of human retinal fascin gene (FSCN2) causes autosomal dominant retinitis pigmentosa., PMID:11527955
Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes., PMID:10783262
For research use only. Not for human or drug use.
