Catalog No.
YHA32701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys342
Predicted molecular weight
41.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14862
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Absent in melanoma 2, Interferon-inducible protein AIM2, AIM2
Hydroxysafflor Yellow A Ameliorates Ischemic Stroke by Inhibiting NLRP3, AIM2, and Pyrin Inflammasome-Mediated Pyroptosis., PMID:40512290
Anti-Inflammatory Potential of Essential Oil from the Heart-Wood of the Folk Medicinal Tree Cinnamomum kanehirai Hayata in Macrophages., PMID:40508226
Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer., PMID:40492347
NLRP3 activation promotes cGAS/STING signaling and antitumor immunity by colorectal cancer cells., PMID:40481953
Neutrophil Extracellular Traps Promote AIM2-Dependent Microglial Pyroptosis Following Stroke., PMID:40479571
AIM2-Driven Inflammation in Periodontitis: Mechanisms and Systemic Implications., PMID:40463858
Transcriptomic and Immunopathological Profiles of Inflammasomes in Different Clinical Forms of American Cutaneous Leishmaniasis., PMID:40431153
AIM2 mediated neuron PANoptosis plays an important role in diabetes cognitive dysfunction., PMID:40404017
Vitexin mitigates AIM2 inflammasome-mediated mitochondrial dysfunction and neuroinflammation in chronic constriction injury induced neuropathy model., PMID:40388859
The dual roles of human PYHIN family proteins in cancer: mechanisms and therapeutic implications., PMID:40386782
rFIP-nha activates macrophages towards a pro-inflammatory phenotype via AIM2 inflammasome modulation., PMID:40356602
ZBP1 synchronized with periodontopathogenesis as the essential pattern recognition receptor., PMID:40349992
Zn2+ regulates mitochondrial DNA efflux to inhibit AIM2-mediated ZBP1-PANoptosome pathway and alleviate septic myocardial injury., PMID:40348119
Acetylation modification of AIM2 by KAT2B suppresses the AKT/Wnt/β-catenin signaling pathway activation and inhibits breast cancer progression., PMID:40317048
NETs activate AIM2 to mediate synovial fibroblast pyroptosis and promote acute gouty arthritis development., PMID:40267802
Mitochondrial DNA signals driving immune responses: Why, How, Where?, PMID:40264103
Broxyquinoline targets NLRP3 to inhibit inflammasome activation and alleviate NLRP3-associated inflammatory diseases., PMID:40253767
Investigation of PANoptosis pathway in age-related macular degeneration triggered by Aβ1-40., PMID:40251333
NLRP3 Inflammasome-mediated pyroptosis in acute lung injury: Roles of main lung cell types and therapeutic perspectives., PMID:40184810
Targeting NLRP3 and AIM2 signaling pathways by Viscosol alleviates metabolic dysregulations induced inflammatory responses in diabetic neuro- and nephropathy: An in silico and in vivo study., PMID:40173145
Streptococcus anginosus Activates the NLRP3 Inflammasome to Promote Inflammatory Responses from Macrophages., PMID:40161672
Role of inflammasomes in cancer immunity: mechanisms and therapeutic potential., PMID:40155968
Identification and validation of fibroblast-related biomarkers in rheumatoid arthritis by bulk RNA-seq and single-cell RNA-seq analysis., PMID:40153321
CRM1 mediates ASC nuclear export and inflammasome activation., PMID:40139094
Card9 deficiency exacerbates vulvovaginal candidiasis by impairing the IL-17 production and vaginal epithelial barrier., PMID:40118504
Discovery of Novel Sulfonylurea NLRP3 Inflammasome Inhibitor for the Treatment of Multiple Inflammatory Diseases., PMID:40112040
AIM2 exacerbates hypoxic-ischemic brain damage in neonatal rats via promoting neuronal pyroptosis., PMID:40101806
NLRP3 and AIM2 inflammasomes exacerbate the pathogenic Th17 cell response to eggs of the helminth Schistosoma mansoni., PMID:40100932
Altered Cellular Pathways in the Blood of Patients With Guillain-Barre Syndrome., PMID:40099626
Artificial intelligence-powered prediction of AIM-2 inflammasome sequences using transformers and graph attention networks in periodontal inflammation., PMID:40082687
The Selective 3-MST Inhibitor I3MT-3 Works as a Potent Caspase-1 Inhibitor., PMID:40076859
Molecular characteristics of oligomeric protein complexes AIM2 and TM4SF19 and their association with the pathogenesis of oral squamous cell carcinoma: Potential biomarkers., PMID:40057077
The cGAS-STING-related signature affects the prognosis of colorectal cancer through its regulation of multiple immune cells., PMID:40035384
Correlation Analysis of Pyroptosis-Related Genes CASP1, NLRP3, AIM2, and NLRP1 With Lung Adenocarcinoma., PMID:40026444
Exploration of the role of AIM2/IL-1β in adult laryngeal papilloma., PMID:40025877
The Inflammasome: A Promising Potential Therapeutic Target for Early Brain Injury Following Subarachnoid Hemorrhage., PMID:40018941
Shengmai-Yin resists myocardial ischemia reperfusion injury by inhibiting K27 ubiquitination of absent in melanoma 2., PMID:40010555
CD177+ neutrophils exacerbate septic lung injury via the NETs/AIM2 pathway: An experimental and bioinformatics study., PMID:40007380
Methamphetamine and HIV-1 Tat Synergistically Induce Microglial Pyroptosis Via Activation of the AIM2 Inflammasome., PMID:39969742
Pyroptosis: A Novel Therapeutic Target for Bioactive Compounds in Human Disease Treatment? A Narrative Review., PMID:39940319
Ochratoxin A induces lung cell PANoptosis through activation of the AIM 2 inflammasome., PMID:39938165
AIM2 targeting of nuclear DNA leakage in dendritic cells exacerbates vasculitis in a murine model of Kawasaki disease., PMID:39903175
Role of inflammasomes in acute respiratory distress syndrome., PMID:39884849
Tissue-invasive Pathogens in Periodontitis Patients and Their Correlation with Pro-inflammatory Markers: An Analytical Case-control Study., PMID:39873262
Titanium particle-induced inflammasome in human gingival epithelial cells., PMID:39873089
Absent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy., PMID:39870644
Emerging role of PANoptosis in kidney diseases: molecular mechanisms and therapeutic opportunities., PMID:39833634
Activation and evasion of inflammasomes during viral and microbial infection., PMID:39833559
Scutellarin inhibits pyroptosis via selective autophagy degradation of p30/GSDMD and suppression of ASC oligomerization., PMID:39824372
Role of AIM2 and cGAS-STING signaling in high fat high carbohydrate diet-induced gut dysbiosis associated neurodegeneration., PMID:39805489
For research use only. Not for human or drug use.
