Catalog No.
YHA29901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro290-Glu642
Predicted molecular weight
43.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14777
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HEC1, Kinetochore protein Hec1, HsHec1, HEC, Kinetochore protein NDC80 homolog, Kinetochore-associated protein 2, NDC80, Highly expressed in cancer protein, Retinoblastoma-associated protein HEC, KNTC2
Expression of kinetochore component NDC80 promotes esophageal squamous cell carcinoma cells proliferation and migration., PMID:40474064
Identification of key biomarker genes in liver hepatocellular carcinoma and kidney renal clear cell carcinoma progression: A shared high-throughput screening and molecular docking method with potentials for targeted therapeutic interventions., PMID:40390492
AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation., PMID:40328643
Network-Based Integrative Analysis to Identify Key Genes and Corresponding Reporter Biomolecules for Triple-Negative Breast Cancer., PMID:40287845
Cell-Type-Specific Heat-Induced Changes in the Proteomes of Pollen Mother Cells and Microspores Provide New Insights into Tomato Pollen Production Under Elevated Temperature., PMID:40265418
Molecular basis identification and hypnotic drug interactions for cognitive impairment related to sleep deprivation., PMID:40229714
Proximity-based activation of AURORA A by MPS1 potentiates error correction., PMID:40203828
Spindle integrity is regulated by a phospho-dependent interaction between the Ndc80 and Dam1 kinetochore complexes., PMID:40184422
Ndc80 complex, a conserved coupler for kinetochore-microtubule motility, is a sliding molecular clutch., PMID:40161670
Analysis of a cancer-associated mutation in the budding yeast Nuf2 kinetochore protein., PMID:40161439
Towards identification of a holocentromere marker in the lepidopteran model Spodoptera frugiperda., PMID:40067534
Development of a MVI associated HCC prognostic model through single cell transcriptomic analysis and 101 machine learning algorithms., PMID:40055377
Decoding oral cancer: insights from miRNA expression profiles and their regulatory targets., PMID:39935706
The KNL-1/Knl1 outer kinetochore protein caught regulating F-actin., PMID:39820668
Berberine restrains non-small cell lung cancer cell growth, invasion and glycolysis via inactivating the SPC25/NUF2 pathway., PMID:39755832
A role for the kinetochore protein, NUF2, in ribosome biogenesis., PMID:39705402
Binding site maturation modulated by molecular density underlies Ndc80 binding to kinetochore receptor CENP-T., PMID:39700145
The kinetochore protein KNL-1 regulates the actin cytoskeleton to control dendrite branching., PMID:39625434
NUF2 Promotes Breast Cancer Metastasis via Activating Wnt/β-Catenin Pathways., PMID:39614440
Clinical and prognostic significance of Hec1 expression in patients with Cervical Cancer., PMID:39544289
α-tubulin detyrosination fine-tunes kinetochore-microtubule attachments., PMID:39521805
SEC-SAXS/MC Ensemble Structural Studies of the Microtubule Binding Protein Cdt1 Show Monomeric, Folded-Over Conformations., PMID:39503309
Unveiling the genetic link and pathogenesis between psoriasis and IgA nephropathy based on Mendelian randomization and transcriptome data analyses., PMID:39460798
Novel insights into the circadian modulation of lipid metabolism in chicken livers revealed by RNA sequencing and weighted gene co-expression network analysis., PMID:39361997
Identification of exosome-related gene features in psoriasis and construction of a diagnostic model via integrated bioinformatics analysis., PMID:39358990
Artificial kinetochore beads establish a biorientation-like state in the spindle., PMID:39298589
On discovery of novel hub genes for ER+ and TN breast cancer types through RNA seq data analyses and classification models., PMID:39242688
Targeting NUF2 suppresses gastric cancer progression through G2/M phase arrest and apoptosis induction., PMID:39193700
Integrating bioinformatics and machine learning methods to analyze diagnostic biomarkers for HBV-induced hepatocellular carcinoma., PMID:39095799
The Molecular Mechanism of Aurora-B Regulating Kinetochore-Microtubule Attachment in Mitosis and Oocyte Meiosis., PMID:39068909
Identification of Hub Genes for Psoriasis and Cancer by Bioinformatic Analysis., PMID:39045407
NDC80/HEC1 promotes macrophage polarization and predicts glioma prognosis via single-cell RNA-seq and in vitro experiment., PMID:39021287
Knockdown of NUF2-derived exosomes can inhibit the migration and autophagy of BC cells and improve resistance to doxorubicin., PMID:38964084
Proximity-based activation of AURORA A by MPS1 potentiates error correction., PMID:38948877
WZ-3146 acts as a novel small molecule inhibitor of KIF4A to inhibit glioma progression by inducing apoptosis., PMID:38937742
Meiosis-specific functions of kinetochore protein SPC105R required for chromosome segregation in Drosophila oocytes., PMID:38865189
A conserved site on Ndc80 complex facilitates dynamic recruitment of Mps1 to yeast kinetochores to promote accurate chromosome segregation., PMID:38776906
A communication hub for phosphoregulation of kinetochore-microtubule attachment., PMID:38776904
Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor., PMID:38776902
NDC80 Kinetochore Complex Serves as a Potential Prognostic Predictor and Correlates with Immune Infiltrates in Epithelial Ovarian Cancer Patients., PMID:38711823
Role of CENPF and NDC80 in the rehabilitation nursing of hepatocellular carcinoma and cirrhosis: An observational study., PMID:38701255
The outer kinetochore components KNL-1 and Ndc80 complex regulate axon and neuronal cell body positioning in the C. elegans nervous system., PMID:38656792
Spindle component 25 predicts the prognosis and the immunotherapy response of cancers: a pan-cancer analysis., PMID:38605119
Meiosis-specific functions of kinetochore protein SPC105R required for chromosome segregation in Drosophila oocytes., PMID:38559067
Binding Site Maturation Modulated by Molecular Density Underlies Ndc80 Binding to Kinetochore Receptor CENP-T., PMID:38464265
Structure of the human KMN complex and implications for regulation of its assembly., PMID:38459128
Structure of the human outer kinetochore KMN network complex., PMID:38459127
SPC25 Functions as a Prognostic-Related Biomarker, and Its High Expression Correlates with Tumor Immune Infiltration and UCEC Progression., PMID:38420826
KNL1 and NDC80 represent new universal markers for the detection of functional centromeres in plants., PMID:38403686
Coregulation of NDC80 Complex Subunits Determines the Fidelity of the Spindle-Assembly Checkpoint and Mitosis., PMID:38324016
For research use only. Not for human or drug use.
