Catalog No.
YHA26701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu356-Glu606
Predicted molecular weight
30.23 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14678
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ATP-binding cassette sub-family D member 4, ABCD4, PXMP1-L, PMP70-related protein, Peroxisomal membrane protein 1-like, P70R, PMP69, Peroxisomal membrane protein 69, PXMP1L, Lysosomal cobalamin transporter ABCD4
Multiple association studies identify 3 novel candidate genes for teat number trait in Danish Landrace and Large White pigs: BRINP3, LIN52, and UBE3B., PMID:40305433
Effect of different Lys/Met ratios in a low-protein diet on the meat quality of Tibetan sheep: A transcriptomics- and metabolomics-based analysis., PMID:39986761
Phenotype puzzle: the role of novel LMBRD1 gene variant in Cbl deficiency causing Dyskeratosis Congenita-like clinical manifestations., PMID:39939801
Dissecting the role of vitamin B12 metabolism in craniofacial development through analysis of clinical phenotypes and model organism discoveries., PMID:39676000
Prospecting Specific Protein Patterns for High Body Mass Index (BMI), Metabolic Syndrome and Type 2 Diabetes in Saliva and Blood Plasma From a Brazilian Population., PMID:39073314
ABCD4 is associated with mammary gland development in mammals., PMID:38764031
Structural bioinformatics studies of six human ABC transporters and their AlphaFold2-predicted water-soluble QTY variants., PMID:38577032
Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation., PMID:38565986
Whole-Genome Resequencing of Ujimqin Sheep Identifies Genes Associated with Vertebral Number., PMID:38473062
Transmembrane helix 6 of ABCD4 is indispensable for cobalamin transport., PMID:38069516
Protein expression and localization of ABC transporters in pancreatic adenocarcinoma: Prognostic role of ABCC8., PMID:37839922
The complex machinery of human cobalamin metabolism., PMID:36680553
Substrate Specificity and the Direction of Transport in the ABC Transporters ABCD1-3 and ABCD4., PMID:35908918
Cobalamin F deficiency in a girl with severe skin hyperpigmentation and a homozygous LMBRD1 variant., PMID:34958133
Prenatal diagnosis of combined methylmalonic acidemia and homocystinuria cobalamin C type using clinical exome sequencing and targeted gene analysis., PMID:34655177
Across Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells., PMID:34579568
The lysosomal protein ABCD4 can transport vitamin B12 across liposomal membranes in vitro., PMID:33845046
Cobalamin J disease detected on newborn screening: Novel variant and normal neurodevelopmental course., PMID:33729671
Role of Genetic Variation in ABC Transporters in Breast Cancer Prognosis and Therapy Response., PMID:33334016
An inventory of lysosomal ABC transporters., PMID:33098571
Cryo-EM structure of human lysosomal cobalamin exporter ABCD4., PMID:31467407
Loss of abcd4 in zebrafish leads to vitamin B12-deficiency anemia., PMID:31113616
A QTL for Number of Teats Shows Breed Specific Effects on Number of Vertebrae in Pigs: Bridging the Gap Between Molecular and Quantitative Genetics., PMID:30972109
Patients with cobalamin G or J defect missed by the current newborn screening program: diagnosis and novel mutations., PMID:30651581
Characterization of human ATP-binding cassette protein subfamily D reconstituted into proteoliposomes., PMID:29397936
Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B12-trafficking proteins ABCD4 and LMBD1., PMID:28572511
ABC Transporter Subfamily D: Distinct Differences in Behavior between ABCD1-3 and ABCD4 in Subcellular Localization, Function, and Human Disease., PMID:27766264
Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1., PMID:27456980
Lessons in biology from patients with inherited disorders of vitamin B12 and folate metabolism., PMID:27163846
Gene expression profile of ABC transporters and cytotoxic effect of ibuprofen and acetaminophen in an epithelial ovarian cancer cell line in vitro., PMID:26200827
Purification and interaction analyses of two human lysosomal vitamin B12 transporters: LMBD1 and ABCD4., PMID:25535791
Role of NH2-terminal hydrophobic motif in the subcellular localization of ATP-binding cassette protein subfamily D: common features in eukaryotic organisms., PMID:25301552
Progressive hyperpigmentation in a Taiwanese child due to an inborn error of vitamin B12 metabolism (cblJ)., PMID:25234635
Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets., PMID:23754956
Defect of cobalamin intracellular metabolism presenting as diabetic ketoacidosis: a rare manifestation., PMID:23546813
Late onset of symptoms in an atypical patient with the cblJ inborn error of vitamin B12 metabolism: diagnosis and novel mutation revealed by exome sequencing., PMID:23141461
Mutations in ABCD4 cause a new inborn error of vitamin B12 metabolism., PMID:22922874
The role of ABC transporters in progression and clinical outcome of colorectal cancer., PMID:22294766
Host response transcriptional profiling reveals extracellular components and ABC (ATP-binding cassette) transporters gene enrichment in typhoid fever-infected Nigerian children., PMID:21914192
Two novel mutations in African and Asian children with progressive familial intrahepatic cholestasis type 3., PMID:21514256
Conservation of targeting but divergence in function and quality control of peroxisomal ABC transporters: an analysis using cross-kingdom expression., PMID:21476988
Identification of novel SNPs of ABCD1, ABCD2, ABCD3, and ABCD4 genes in patients with X-linked adrenoleukodystrophy (ALD) based on comprehensive resequencing and association studies with ALD phenotypes., PMID:20661612
Induction of the adrenoleukodystrophy-related gene (ABCD2) by thyromimetics., PMID:19406244
70-kDa peroxisomal membrane protein related protein (P70R/ABCD4) localizes to endoplasmic reticulum not peroxisomes, and NH2-terminal hydrophobic property determines the subcellular localization of ABC subfamily D proteins., PMID:19010322
Effect of dietary polyunsaturated fatty acids on the expression of peroxisomal ABC transporters., PMID:18585430
High-resolution copy number and gene expression microarray analyses of head and neck squamous cell carcinoma cell lines of tongue and larynx., PMID:18314910
Mapping ATP-binding cassette transporter gene expression profiles in melanocytes and melanoma cells., PMID:17885581
Dehydroepiandrosterone up-regulates the Adrenoleukodystrophy-related gene (ABCD2) independently of PPARalpha in rodents., PMID:17686565
The peroxisomal ABC transporter family., PMID:17039367
For research use only. Not for human or drug use.
