Catalog No.
YHA20201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Val198
Predicted molecular weight
24.48 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14508
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CIS-2, STAT-induced STAT inhibitor 2, SSI-2, SOCS2, STATI2, CIS2, Cytokine-inducible SH2 protein 2, SSI2, Suppressor of cytokine signaling 2, SOCS-2
Botulinum toxin A prevents hypertrophic scarring by suppressing PARP14/SOCS2-mediated M2 polarization of macrophages., PMID:40505894
Genome-wide identification of socs gene in rainbow trout (Oncorhynchus mykiss) and response to microplastic exposure., PMID:40402276
Mechanisms of Fetal Overgrowth in Gestational Diabetes: The Potential Role of SOCS2., PMID:40362828
Regulation of Immune-Related Gene Expression by Salinity-Induced HPI Axis in Large Yellow Croaker, Larimichthys crocea., PMID:40362534
Suppressor of cytokine signaling 2 modulates regulatory T cell activity to suppress liver hepatocellular carcinoma growth and metastasis., PMID:40248063
Genetic and Epigenetic Adaptation Mechanisms of Sheep Under Multi-Environmental Stress Environment., PMID:40244095
Editorial: SOCS: regulation of the immune system at a whole new level., PMID:40207225
Modulation of Macrophages TLR4-Mediated Transcriptional Response by Lacticaseibacillus rhamnosus CRL1505 and Lactiplantibacillus plantarum CRL1506., PMID:40141330
Modified expression of JAK-STAT pathway genes in an in vivo rheumatoid arthritis model: A preclinical study to explore genetic insights., PMID:40073707
Loss of Socs2 improves molecular responses to IFNα in a mouse model of myeloproliferative neoplasms driven by JAK2-V617F., PMID:40069287
Comparative characterization of human accelerated regions in neurons., PMID:40011774
Gut microbiome-derived indole-3-carboxaldehyde regulates stress vulnerability in chronic restraint stress by activating aryl hydrocarbon receptors., PMID:39946793
Optimization of CRISPR/Cas9 Gene Editing System in Sheep (Ovis aries) Oocytes via Microinjection., PMID:39940839
SOCS2 inhibits the tumorigenesis of GISTs and increases the sensitivity of GISTs to imatinib by suppression of KIT activation., PMID:39922931
BCL6 coordinates muscle mass homeostasis with nutritional states., PMID:39841144
Efficient Generation of SOCS2 Knock-Out Sheep by Electroporation of CRISPR-Cas9 Ribonucleoprotein Complex with Dual-sgRNAs., PMID:39807995
METTL3 inhibition promotes radiosensitivity in hepatocellular carcinoma through regulation of SLC7A11 expression., PMID:39799112
Elevated levels of exogenous prolactin promote inflammation at the maternal-fetal interface via the JAK2/STAT5B signaling axis., PMID:39763651
Leveraging Therapeutic Proteins and Peptides from Lumbricus Earthworms: Targeting SOCS2 E3 Ligase for Cardiovascular Therapy through Molecular Dynamics Simulations., PMID:39409145
Exhausted signature and regulatory network of NK cells in myasthenia gravis., PMID:39346912
The investigation of SNP in SOCS2 gene and its effect on milk yield, fat, protein, and somatic cell count in Awassi ewes., PMID:39312078
Expression Characteristics, Immune Signature, and Prognostic Value of the SOCS Family Identified by Multiomics Integrative Analysis in Liver Cancer., PMID:39307915
Bivariate genome-wide association study of circulating fibrinogen and C-reactive protein levels., PMID:39299614
FGF21 upregulation by hepatitis C virus via the eIF2α-ATF4 pathway: implications for interferon signaling suppression and TRIM31-mediated TSC degradation., PMID:39211324
A loss of function mutation in SOCS2 results in increased inflammatory response of macrophages to TLR ligands and Staphylococcus aureus., PMID:39185412
Identification and analysis of significant genes in nonalcoholic steatohepatitis-hepatocellular carcinoma transformation: Bioinformatics analysis and machine learning approach., PMID:39142007
Analysis of machine learning based integration to identify the crosslink between inflammation and immune response in non-alcoholic fatty liver disease through bioinformatic analysis., PMID:39108890
Inhibition of DDR1 promotes ferroptosis and overcomes gefitinib resistance in non-small cell lung cancer., PMID:39089636
Targeting SOCS2 alleviates myocardial fibrosis by reducing nuclear translocation of β-catenin., PMID:39084528
Leonurine Exerts Anti-Inflammatory Effects in Lipopolysaccharide (LPS)-Induced Endometritis by Modulating Mouse JAK-STAT/PI3K-Akt/PPAR Signaling Pathways., PMID:39062636
The Interplay Between Helicobacter pylori and Suppressors of Cytokine Signaling (SOCS) Molecules in the Development of Gastric Cancer and Induction of Immune Response., PMID:38924222
CEBPA Restrains the Malignant Progression of Breast Cancer by Prompting the Transcription of SOCS2., PMID:38775935
Dietary supplementation of Chinese herbal medicines enhances the immune response and resistance of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus., PMID:38694480
Desflurane alleviates LPS-induced acute lung injury by modulating let-7b-5p/HOXA9 axis., PMID:38676899
A hypoxia-glycolysis-lactate-related gene signature for prognosis prediction in hepatocellular carcinoma., PMID:38627714
Research Note: SOCS2 contributes to reduction of the third digit during development of the chicken forelimb., PMID:38564834
Coordinated activation of DNMT3a and TET2 in cancer stem cell-like cells initiates and sustains drug resistance in hepatocellular carcinoma., PMID:38528605
Integrating single-cell and bulk sequencing data to identify glycosylation-based genes in non-alcoholic fatty liver disease-associated hepatocellular carcinoma., PMID:38515461
Effect of IGFBP-4 during In Vitro Maturation on Developmental Competence of Bovine Cumulus Oocyte Complexes., PMID:38473060
Mutation of SOCS2 induces structural and functional changes in mammary development., PMID:38391249
OCA-B/Pou2af1 is sufficient to promote CD4+ T cell memory and prospectively identifies memory precursors., PMID:38386711
ZEB1 shapes AML immunological niches, suppressing CD8 T cell activity while fostering Th17 cell expansion., PMID:38363677
Ammonia stress-induced heat shock factor 1 enhances white spot syndrome virus infection by targeting the interferon-like system in shrimp., PMID:38358252
POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer., PMID:38267746
MiR-9 promotes G-MDSC recruitment and tumor proliferation by targeting SOCS3 in breast cancer., PMID:38145323
Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging., PMID:38103096
A three-gene signature reveals changes in the tumor immune microenvironment in the progression from NAFLD to HCC., PMID:38102321
CTRP6 protects against ferroptosis to drive lung cancer progression and metastasis by destabilizing SOCS2 and augmenting the xCT/GPX4 pathway., PMID:38084702
SOCS2 inhibits hepatoblastoma metastasis via downregulation of the JAK2/STAT5 signal pathway., PMID:38071211
Inhibition of miR-578 through SOCS2-dependent manner reverses gefitinib resistance in NSCLC cells., PMID:37948135
For research use only. Not for human or drug use.
