Catalog No.
YHA19201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln29-Lys253
Predicted molecular weight
27.73 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00764
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Pyridoxine kinase, Pyridoxal kinase, C21orf97, PDXK, PNK, PKH, C21orf124
Combinatorial Metabolic Engineering of Escherichia coli MG1655 Enables Efficient Biosynthesis of Vitamin B6., PMID:40445068
Delivery of exogenous miR-19b by Wharton's Jelly Mesenchymal Stem Cells attenuates transplanted kidney ischemia/reperfusion injury by regulating cellular metabolism., PMID:38918324
Butyrate inhibits the malignant biological behaviors of breast cancer cells by facilitating cuproptosis-associated gene expression., PMID:38833016
Pyridoxal kinase gene deletion leads to impaired growth, deranged redox metabolism and cell cycle arrest in Leishmania donovani., PMID:38403043
Discovery and characterization of natural product luteolin as an effective inhibitor of human pyridoxal kinase., PMID:38150934
New Insights Into Pyridoxal Kinase Inhibitors and Their Antileukemic Effects., PMID:38046746
Cheminformatics-based discovery of new organoselenium compounds with potential for the treatment of cutaneous and visceral leishmaniasis., PMID:37937770
Protein-Protein Interfaces as Druggable Targets: A Common Motif of the Pyridoxal-5'-Phosphate-Dependent Enzymes to Receive the Coenzyme from Its Producers., PMID:37751871
Vitamin B6 is governed by the local compartmentalization of metabolic enzymes during growth., PMID:37682999
Identification of high-affinity pyridoxal kinase inhibitors targeting cancer therapy: an integrated docking and molecular dynamics simulation approach., PMID:37578056
The Therapeutic Potential of Vitamins B1, B3 and B6 in Charcot-Marie-Tooth Disease with the Compromised Status of Vitamin-Dependent Processes., PMID:37508330
Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation., PMID:37217797
4'-Deoxypyridoxine disrupts vitamin B6 homeostasis in Escherichia coli K12 through combined inhibition of cumulative B6 uptake and PLP-dependent enzyme activity., PMID:37040165
Investigation of enzymatic quality and quantity using pyridoxal 5'-phosphate (PLP) regeneration system as a decoy in Escherichia coli., PMID:36841388
Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma., PMID:36750831
Identification of Epigenetically Regulated Genes Distinguishing Intracranial from Extracranial Melanoma Metastases., PMID:36716920
Pyridoxal Kinase of Disease-causing Human Parasites: Structural and Functional Insights to Understand its Role in Drug Discovery., PMID:35598242
Screening for Prognostic Biomarkers in Metastatic Adrenocortical Carcinoma by Tissue Micro Arrays Analysis Identifies P53 as an Independent Prognostic Marker of Overall Survival., PMID:35565353
Proteomic analysis of serum in workers exposed to diesel engine exhaust., PMID:34894159
Metabolic features of cancer cells impact immunosurveillance., PMID:34162714
Plasmid-Free System and Modular Design for Efficient 5-Aminolevulinic Acid Production by Engineered Escherichia coli., PMID:33860878
Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models., PMID:33707583
Inborn errors in the vitamin B6 salvage enzymes associated with neonatal epileptic encephalopathy and other pathologies., PMID:33421502
Pyridoxal kinase inhibition by artemisinins down-regulates inhibitory neurotransmission., PMID:33318193
Integrated gene engineering synergistically improved substrate-product transport, cofactor generation and gene translation for cadaverine biosynthesis in E. coli., PMID:33301846
Hereditary polyneuropathy with optic atrophy due to PDXK variant leading to impaired Vitamin B6 metabolism., PMID:32522499
Characterization of hydroxymethylpyrimidine phosphate kinase from mesophilic and thermophilic bacteria and structural insights into their differential thermal stability., PMID:32387178
Pyridoxal Reductase, PdxI, Is Critical for Salvage of Pyridoxal in Escherichia coli., PMID:32253339
CircFOXK2 Promotes Growth and Metastasis of Pancreatic Ductal Adenocarcinoma by Complexing with RNA-Binding Proteins and Sponging MiR-942., PMID:32217695
Structural attributes and substrate specificity of pyridoxal kinase from Leishmania donovani., PMID:32105687
Predictive biomarkers of platinum and taxane resistance using the transcriptomic data of 1816 ovarian cancer patients., PMID:31973910
Vitamin B6 Addiction in Acute Myeloid Leukemia., PMID:31935373
The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity., PMID:31578392
PDXK mutations cause polyneuropathy responsive to pyridoxal 5'-phosphate supplementation., PMID:31187503
Pyridoxal kinase: A vitamin B6 salvage pathway enzyme from Leishmania donovani., PMID:30031075
Systematic Functional Characterization of Human 21st Chromosome Orthologs in Caenorhabditis elegans., PMID:29367452
Identification of YbhA as the pyridoxal 5'-phosphate (PLP) phosphatase in Escherichia coli: Importance of PLP homeostasis on the bacterial growth., PMID:29187681
Isolation and characterization of the 5'-flanking region of the human PDXK gene., PMID:28716709
A loss of Pdxk model of Parkinson disease in Drosophila can be suppressed by Buffy., PMID:28606139
Lentivirus-mediated microRNA-124 gene-modified bone marrow mesenchymal stem cell transplantation promotes the repair of spinal cord injury in rats., PMID:28524176
Salmonella typhimurium PtsJ is a novel MocR-like transcriptional repressor involved in regulating the vitamin B6 salvage pathway., PMID:27987384
Role of RNA-interference-induced zinc finger protein 139 suppression in gastric cancer cell sensitivity to chemotherapeutic agents., PMID:26622672
Negative prognostic value of high levels of intracellular poly(ADP-ribose) in non-small cell lung cancer., PMID:26387143
Proteomics profiling identify CAPS as a potential predictive marker of tamoxifen resistance in estrogen receptor positive breast cancer., PMID:25878567
Implications of polyadenylation in health and disease., PMID:25484187
Purification, crystallization and preliminary X-ray diffraction analysis of pyridoxal kinase from Plasmodium falciparum (PfPdxK)., PMID:25372829
Successful data recovery from oscillation photographs containing strong polycrystalline diffraction rings from an unknown small-molecule contaminant: preliminary structure solution of Salmonella typhimurium pyridoxal kinase (PdxK)., PMID:24699755
Prognostic value of LIPC in non-small cell lung carcinoma., PMID:23343765
Vitamin B6 metabolism influences the intracellular accumulation of cisplatin., PMID:23287530
Alternative cleavage and polyadenylation during colorectal cancer development., PMID:22874640
For research use only. Not for human or drug use.
