Catalog No.
YHA08901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His601-Glu870
Predicted molecular weight
34.49 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00308
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Atrophin-1-interacting protein 2, WWP2, AIP2, WW domain-containing protein 2, HECT-type E3 ubiquitin transferase WWP2, NEDD4-like E3 ubiquitin-protein ligase WWP2
ARRDC3 tyrosine phosphorylation functions as a switch to control c-Src versus WWP2 interactions and distinct scaffolding functions., PMID:40409556
The Ubiquitination and Degradation of SH2B3 Mediated by MEF2A/WWP2 Axis Restores Microglial Homeostasis to Alleviate Cerebral Microvascular Endothelial Cell Injury in Ischemic Stroke., PMID:40407948
Ubiquitin-proteasome Pathway-linked Gene Signatures as Prognostic Indicators in Prostate Cancer., PMID:40295064
LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux., PMID:40280227
HSP90 regulates dCK stability and inhibits ionizing radiation-induced ferroptosis in cervical cancer cells., PMID:40263268
A Novel Prognostic Signature of Mitophagy-Related E3 Ubiquitin Ligases in Breast Cancer., PMID:40004017
Sculponeatin A induces mitochondrial dysfunction in non-small cell lung cancer through WWP2-mediated degradation of mitochondrial STAT3., PMID:39993792
The splicing factor SRRM2 modulates two S6K kinases to promote colorectal cancer growth., PMID:39956864
DEF6 regulates renal ischemia reperfusion injury through suppressing the WWP2 mediated ubiquitination of PARP1., PMID:39837430
A Novel IgG-IgM Autoantibody Panel Enhances Detection of Early-stage Lung Adenocarcinoma from Benign Nodules., PMID:39661479
Proteomics analysis of extracellular vesicles for biomarkers of autism spectrum disorder., PMID:39606031
Histone demethylase PHF8 protected against chondrocyte injury and alleviated posttraumatic osteoarthritis by epigenetically enhancing WWP2 expression., PMID:39454680
Stage analysis of pancreatic ductal adenocarcinoma via network analysis., PMID:39308540
Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases., PMID:39223706
Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity., PMID:39196068
CMTM5 influences Hippo/YAP axis to promote ferroptosis in glioma through regulating WWP2-mediated LATS2 ubiquitination., PMID:39166861
Ubiquitination of NS1 Confers Differential Adaptation of Zika Virus in Mammalian Hosts and Mosquito Vectors., PMID:39159062
Lysosomal-Associated Protein Transmembrane 5, Tubular Senescence, and Progression of CKD., PMID:39078711
WWP2 deletion aggravates acute kidney injury by targeting CDC20/autophagy axis., PMID:38909885
Herpes simplex encephalitis due to a mutation in an E3 ubiquitin ligase., PMID:38730242
Large-scale cross-ancestry genome-wide meta-analysis of serum urate., PMID:38658550
WWP2 protects against sepsis-induced cardiac injury through inhibiting cardiomyocyte ferroptosis., PMID:38591063
Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence., PMID:38570801
WWP2 Regulates Renal Fibrosis and the Metabolic Reprogramming of Profibrotic Myofibroblasts., PMID:38502123
E3 ubiquitin ligase WWP2 as a promising therapeutic target for diverse human diseases., PMID:38430667
The biogenesis, identification, and functionality of circWWP2 in lipopolysaccharide stimulated macrophages., PMID:38316263
Quantification of AMPA receptor subunits and RNA editing-related proteins in the J20 mouse model of Alzheimer's disease by capillary western blotting., PMID:38299128
A positive feedback between PDIA3P1 and OCT4 promotes the cancer stem cell properties of esophageal squamous cell carcinoma., PMID:38254118
The role of WWP1 and WWP2 in bone/cartilage development and diseases., PMID:38252355
Proliferation, migration and phenotypic transformation of VSMC induced via Hcy related to up-expression of WWP2 and p-STAT3., PMID:38166045
Exploring biomarkers in trigeminal neuralgia patients operated with microvascular decompression: A comparison with multiple sclerosis patients and non-neurological controls., PMID:38158702
Genomic Characteristics and Its Therapeutic Implications in Breast Cancer Patients with Detectable Molecular Residual Disease., PMID:38062709
Spatial Mechano-Signaling Regulation of GTPases through Non-Degradative Ubiquitination., PMID:37946677
WWP2 binds to NKRF, enhances the NF-κB signaling, and promotes malignant phenotypes of acute myeloid leukemia cells., PMID:37921219
Apigenin promotes cell death in NCI-H23 cells by upregulation of PTEN: potential involvement of the binding of apigenin with WWP2 protein., PMID:37870050
Identification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis., PMID:37749624
A membrane-associated MHC-I inhibitory axis for cancer immune evasion., PMID:37557169
Atorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A., PMID:37557013
Divergent regulation of α-arrestin ARRDC3 function by ubiquitination., PMID:37223976
Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X., PMID:37149668
Acupuncture improves learning and memory ability of posttraumatic stress disorder model rats through epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway., PMID:37066940
The E3 ubiquitin ligases regulate inflammation in cardiovascular diseases., PMID:36872193
WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein., PMID:36803368
lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1., PMID:36795754
Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1., PMID:36773333
Selection signatures for local and regional adaptation in Chinese Mongolian horse breeds reveal candidate genes for hoof health., PMID:36658473
The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis., PMID:36450710
Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling., PMID:36398662
miR-328-5p Induces Human Intervertebral Disc Degeneration by Targeting WWP2., PMID:36211818
WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes., PMID:36208715
For research use only. Not for human or drug use.
