Catalog No.
YHA01501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn416-Arg670
Predicted molecular weight
29.45 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
A8K7I4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Calcium-activated chloride channel regulator 1, hCLCA1, Calcium-activated chloride channel protein 1, CACC1, CaCC-1, Calcium-activated chloride channel family member 1, hCaCC-1, CLCA1
Calcium-activated chloride channel regulator 1 (CLCA1): More than a regulator of chloride transport and mucus production. PMID: 31871532
Differential Expression Analysis Revealing CLCA1 to Be a Prognostic and Diagnostic Biomarker for Colorectal Cancer. PMID: 33251137
CLCA1 and TMEM16A: the link towards a potential cure for airway diseases. PMID: 26296094
Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement. PMID: 31995732
CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway. PMID: 28974231
Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing properties. PMID: 31570526
Soluble mucus component CLCA1 modulates expression of leukotactic cytokines and BPIFA1 in murine alveolar macrophages but not in bone marrow-derived macrophages. PMID: 29610986
Secretory diarrhoea: mechanisms and emerging therapies. PMID: 26122478
Secreted CLCA1 modulates TMEM16A to activate Ca(2+)-dependent chloride currents in human cells. PMID: 25781344
Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity. PMID: 29885864
CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A. PMID: 34066250
Role of ion channels in gastrointestinal cancer. PMID: 31636470
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. PMID: 24942678
Role of goblet cell protein CLCA1 in murine DSS colitis. PMID: 26855614
[AIRWAY EPITHELIAL CELL DIFFERENTIATION AND HYPERSECRETION -THE ROLE OF IL-13, CLCA1 AND TMEM16A]. PMID: 29129885
Intracellular Ion Channels in Pancreas Cancer. PMID: 31834994
Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation. PMID: 23112050
The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice. PMID: 26162072
Corrigendum: Differential Expression Analysis Revealing CLCA1 to Be a Prognostic and Diagnostic Biomarker for Colorectal Cancer. PMID: 33392101
Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1). PMID: 28420732
Differential association of MUC5AC and CLCA1 expression in small cartilaginous airways of RAO-affected and control horses. PMID: 20095232
Is rabbit CLCA1 related to the basolateral Ca2+ -dependent Cl- channel of gastric parietal cells? PMID: 11282004
Human ClCa1 modulates anionic conduction of calcium-dependent chloride currents. PMID: 19307298
CLCA1 gene polymorphisms in chronic obstructive pulmonary disease. PMID: 14985398
Tight junction, mucin, and inflammasome-related molecules are differentially expressed in eosinophilic, mixed, and neutrophilic experimental asthma in mice. PMID: 30267575
Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis. PMID: 27803115
TMEM16A Mediates Mucus Production in Human Airway Epithelial Cells. PMID: 33026825
Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-D-aspartate receptors. PMID: 18616988
The Emerging Role of Calcium-activated Chloride Channel Regulator 1 in Cancer. PMID: 30952704
Bioinformatics Analysis and Identification of Underlying Biomarkers Potentially Linking Allergic Rhinitis and Asthma. PMID: 32460303
Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer. PMID: 11445004
HO-1 inhibits IL-13-induced goblet cell hyperplasia associated with CLCA1 suppression in normal human bronchial epithelial cells. PMID: 26507166
Association of the CLCA1 p.S357N variant with meconium ileus in European patients with cystic fibrosis. PMID: 20179644
Comparative Proteomics of Ovarian Cancer Aggregate Formation Reveals an Increased Expression of Calcium-activated Chloride Channel Regulator 1 (CLCA1). PMID: 26004777
Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins. PMID: 9828122
The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1. PMID: 11994272
Increased human Ca²⁺-activated Cl⁻ channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients. PMID: 22731784
Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer. PMID: 25603912
Increased mucus accumulation in horses chronically affected with recurrent airway obstruction is not associated with up-regulation of CLCA1, EGFR, MUC5AC, Bcl-2, IL-13 and INF-gamma expression. PMID: 18597857
Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma. PMID: 30419838
High chloride channel accessory 1 expression predicts poor prognoses in patients with rectal cancer receiving chemoradiotherapy. PMID: 30123054
Comparison of the properties of CLCA1 generated currents and I(Cl(Ca)) in murine portal vein smooth muscle cells. PMID: 11850505
Prognostic value of chloride channel accessory mRNA expression in colon cancer. PMID: 31404307
For research use only. Not for human or drug use.
