Catalog No.
YHN54701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Phe209
Predicted molecular weight
25.88 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NRN9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Methyltransferase-like protein 5, METTL5, rRNA N6-adenosine-methyltransferase METTL5
Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5., PMID:40475643
Recent Findings in N6-Methyladenosine Modification and Significance in Pancreatic Cancer., PMID:40448344
Scutellarin suppresses ovarian cancer progression by targeting METTL5., PMID:40425707
TRIM28 mediates Mettl5 ubiquitination to promotes Th2 polarization., PMID:40391221
Modulation of Mettl5 alleviates airway allergy by regulating the epigenetic profile of M2 macrophages., PMID:40089091
METTL5 Promotes Tumor Progression in Oral Squamous Cell Carcinoma by Activating the Myc Pathway., PMID:39870169
METTL4 and METTL5 as biomarkers for recurrence-free survival in hepatocellular carcinoma patients., PMID:39706798
Dust mite antigens endow dendritic cells with the capacity to induce a Th2 response by regulating their methylation profiles., PMID:39695662
METTL5 enhances the mRNA stability of TPRKB through m6A modification to facilitate the aggressive phenotypes of hepatocellular carcinoma cell., PMID:39182664
METTL5: A Potential Biomarker for Nonsmall Cell Lung Cancer That Promotes Cancer Cell Proliferation by Interacting with IGF2BP3., PMID:39023781
The novel m6A writer methyltransferase 5 is a promising prognostic biomarker and associated with immune cell infiltration in oral squamous cell carcinoma., PMID:38939970
The m6A-independent role of epitranscriptomic factors in cancer., PMID:38935523
Biological significance of METTL5 in atherosclerosis: comprehensive analysis of single-cell and bulk RNA sequencing data., PMID:38663914
Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders., PMID:37905873
METTL5-mediated 18S rRNA m6A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression., PMID:37735874
Ghost authors revealed: The structure and function of human N6 -methyladenosine RNA methyltransferases., PMID:37674370
Methyltransferase-like proteins in cancer biology and potential therapeutic targeting., PMID:37533128
METTL5 serves as a diagnostic and prognostic biomarker in hepatocellular carcinoma by influencing the immune microenvironment., PMID:37400463
Effect of prenatal perfluoroheptanoic acid exposure on spermatogenesis in offspring mice., PMID:37262965
Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages., PMID:37217897
Comprehensive analysis of m6A related gene mutation characteristics and prognosis in colorectal cancer., PMID:37194014
N6-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis., PMID:36800991
RNA m6A methylation across the transcriptome., PMID:36736310
METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression., PMID:36602428
Knockdown of METTL5 inhibits the Myc pathway to downregulate PD-L1 expression and inhibits immune escape of hepatocellular carcinoma cells., PMID:36369791
Inhibition of METTL5 improves preimplantation development of mouse somatic cell nuclear transfer embryos., PMID:36111643
METTLing in Stem Cell and Cancer Biology., PMID:36094754
Loss of m6A Methyltransferase METTL5 Promotes Cardiac Hypertrophy Through Epitranscriptomic Control of SUZ12 Expression., PMID:35295259
The potential role of methyltransferase-like 5 in deficient mismatch repair of uterine corpus endometrial carcinoma., PMID:35166644
The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation., PMID:35033535
Ribosome 18S m6A methyltransferase METTL5 promotes pancreatic cancer progression by modulating c‑Myc translation., PMID:34970694
Human TRMT112-Methyltransferase Network Consists of Seven Partners Interacting with a Common Co-Factor., PMID:34948388
m6A regulator expression profile predicts the prognosis, benefit of adjuvant chemotherapy, and response to anti-PD-1 immunotherapy in patients with small-cell lung cancer., PMID:34802443
Expression and prognostic potential of ribosome 18S RNA m6A methyltransferase METTL5 in gastric cancer., PMID:34702266
Analysis of the role of METTL5 as a hub gene in lung adenocarcinoma based on a weighted gene co-expression network., PMID:34517547
[Establishment and validation of prognosis predictive model using m6A RNA methylation regulators in children acute myeloid leukemia]., PMID:34445837
A comprehensive review of m6A/m6Am RNA methyltransferase structures., PMID:34023900
METTL16, Methyltransferase-Like Protein 16: Current Insights into Structure and Function., PMID:33671635
Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima., PMID:33428944
Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth., PMID:33357433
Mettl5 mediated 18S rRNA N6-methyladenosine (m6A) modification controls stem cell fate determination and neural function., PMID:35005123
The 18S ribosomal RNA m6 A methyltransferase Mettl5 is required for normal walking behavior in Drosophila., PMID:32350990
The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs., PMID:32217665
Bi-allelic Variants in METTL5 Cause Autosomal-Recessive Intellectual Disability and Microcephaly., PMID:31564433
The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112., PMID:31328227
Use of Nonradioactive Detection Method for North- and South-Western Blot., PMID:26139255
Use of non-radioactive detection method for north- and southwestern blot., PMID:19378081
For research use only. Not for human or drug use.
