Catalog No.
DHE43301
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Target
NAMPT, Pre-B-cell colony-enhancing factor 1, NAmPRTase, Pre-B cell-enhancing factor, Nicotinamide phosphoribosyltransferase, Visfatin, PBEF, PBEF1, Nampt
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P43490
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
Alt-100, Alt 100, Alt100
Clone ID
Alt-100
Anti-CHI3L1 antibody suppresses colon cancer growth through downregulation of VEGFA and NAMPT expression., PMID:40377878
NAMPT regulates mitochondria and oxidative stress level for mouse early embryo development., PMID:40320561
eNAMPT Is a Novel DAMP and Therapeutic Target in Human and Murine Pulmonary Fibrosis., PMID:40126452
Research progress in bifunctional small molecules for cancer immunotherapy., PMID:39919914
The Gut Microbiota Affects Anti-TNF Responsiveness by Activating the NAD+ Salvage Pathway in Ulcerative Colitis., PMID:39739648
Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) drives abnormal pericyte-rich vasculature in triple-negative breast cancer., PMID:39636369
CD38 ligation in sepsis promotes nicotinamide phosphoribosyltransferase-mediated IL-6 production in kidney stromal cells., PMID:39568061
Inhibition of ethanol-induced eNAMPT secretion attenuates liver ferroptosis through BAT-Liver communication., PMID:39059204
eNAMPT is a novel therapeutic target for mitigation of coronary microvascular disease in type 2 diabetes., PMID:38898303
Identifying hub genes in response to ustekinumab and the impact of ustekinumab treatment on fibrosis in Crohn's disease., PMID:38840917
Extracellular Nicotinamide Phosphoribosyltransferase Is a Therapeutic Target in Experimental Necrotizing Enterocolitis., PMID:38790933
Drug discovery targeting nicotinamide phosphoribosyltransferase (NAMPT): Updated progress and perspectives., PMID:38244254
Antibody drug conjugates beyond cytotoxic payloads., PMID:37981349
Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer., PMID:37880182
Single-Cell Network-Based Drug Repositioning for Discovery of Therapies against Anti-Tumour Necrosis Factor-Resistant Crohn's Disease., PMID:37762402
SARS-CoV-2 infection dysregulates NAD metabolism., PMID:37457744
Recent advances of targeting nicotinamide phosphoribosyltransferase (NAMPT) for cancer drug discovery., PMID:37413882
High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway., PMID:37173894
Involvement of eNAMPT/TLR4 inflammatory signaling in progression of non-alcoholic fatty liver disease, steatohepatitis, and fibrosis., PMID:36809677
Review of various NAMPT inhibitors for the treatment of cancer., PMID:36160449
A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy., PMID:35658441
Is eNAMPT/visfatin a potential serum marker of papillary thyroid cancer?, PMID:35450096
eNAMPT Is a Novel Damage-associated Molecular Pattern Protein That Contributes to the Severity of Radiation-induced Lung Fibrosis., PMID:35167418
Alterations in Kynurenine and NAD+ Salvage Pathways during the Successful Treatment of Inflammatory Bowel Disease Suggest HCAR3 and NNMT as Potential Drug Targets., PMID:34948292
Cisplatin resistance of NSCLC cells involves upregulation of visfatin through activation of its transcription and stabilization of mRNA., PMID:34656559
Involvement of eNAMPT/TLR4 signaling in murine radiation pneumonitis: protection by eNAMPT neutralization., PMID:34139379
Radiation exposure triggers the malignancy of non‑small cell lung cancer cells through the activation of visfatin/Snail signaling., PMID:33432364
The role of visfatin and resistin in an in vitro model of obesity-induced invasive liver cancer., PMID:33356858
Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody., PMID:33243842
NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion., PMID:33171124
Crucial transcripts predict response to initial immunoglobulin treatment in acute Kawasaki disease., PMID:33082496
Role of secreted extracellular nicotinamide phosphoribosyltransferase (eNAMPT) in prostate cancer progression: Novel biomarker and therapeutic target., PMID:33045468
Silencing of NAMPT leads to up-regulation of insulin receptor substrate 1 gene expression in U87 glioma cells., PMID:32597148
Anti-Cancer Activity of PAK4/NAMPT Inhibitor and Programmed Cell Death Protein-1 Antibody in Kidney Cancer., PMID:35224510
Neutralization of extracellular NAMPT (nicotinamide phosphoribosyltransferase) ameliorates experimental murine colitis., PMID:32338310
Role of Nampt overexpression in a rat model of Hashimoto's thyroiditis and its mechanism of action., PMID:32256774
Bioactive fractions from Securidaca inappendiculata alleviated collagen-induced arthritis in rats by regulating metabolism-related signaling., PMID:32187848
Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α., PMID:32142369
Hyperbaric oxygen activates visfatin expression and angiogenesis via angiotensin II and JNK pathway in hypoxic human coronary artery endothelial cells., PMID:31957305
Targeting NAD+ Synthesis to Potentiate CD38-Based Immunotherapy of Multiple Myeloma., PMID:31952784
Corneal Denervation Causes Epithelial Apoptosis Through Inhibiting NAD+ Biosynthesis., PMID:31415077
Multi-dimensional immunoproteomics coupled with in vitro recapitulation of oncogenic NRASQ61R identifies diagnostically relevant autoantibody biomarkers in thyroid neoplasia., PMID:31326556
Controlling cellular distribution of drugs with permeability modifying moieties., PMID:31303996
Monoclonal antibody AC10364 inhibits cell proliferation in 5-fluorouracil resistant hepatocellular carcinoma via apoptotic pathways., PMID:31303763
Visfatin Promotes Wound Healing through the Activation of ERK1/2 and JNK1/2 Pathway., PMID:30463229
Clinical Significance of Serum Visfatin in Renal Transplant Recipients., PMID:30316365
Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody-Drug Conjugates., PMID:30242091
Nicotinamide Phosphate Transferase (NAMPT) Increases in Plasma in Patients with Acute Coronary Syndromes, and Promotes Macrophages to M2 Polarization., PMID:30158377
Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates., PMID:30128077
NAMPT: A pleiotropic modulator of monocytes and macrophages., PMID:30031171
For research use only. Not for human or drug use.
