Catalog No.
DHC21904
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1-kappa
Target
MSK8, VNRA, Vitronectin receptor, Integrin alpha-V, Vitronectin receptor subunit alpha, CD51, ITGAV, VTNR, ITGB6, Integrin beta-6
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P06756 & P18564
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
Bispecific, STX-100, STX100, STX 100
Clone ID
STX-100
Autoantibodies against endothelial protein C receptor and integrin αvβ6 predict the development of ulcerative colitis., PMID:40372451
The Combination of Oncolytic Virus and Antibody Blockade of TGF-β Enhances the Efficacy of αvβ6-Targeting CAR T Cells Against Pancreatic Cancer in an Immunocompetent Model., PMID:40361460
Anti-integrin αvβ6 autoantibody in patients with ulcerative colitis after proctocolectomy: a cross-sectional study in Japan., PMID:40300750
Anti-integrin αvβ6 IgG antibody as a diagnostic and prognostic marker in ulcerative colitis: A cross-sectional and longitudinal study defining a specific disease phenotype., PMID:40251889
Enhanced cytotoxicity against cholangiocarcinoma by fifth-generation chimeric antigen receptor T cells targeting integrin αvβ6 and secreting anti-PD-L1 scFv., PMID:40241132
Anti-Integrin αvβ6 Antibody Titer as a Predictive Biomarker of Future Treatment Escalation in Patients With Ulcerative Colitis., PMID:39926205
Publisher Correction: Anti-integrin αvβ6 antibody as a biomarker for diagnosing ulcerative colitis: a nationwide multicenter validation study., PMID:39729094
Anti-integrin αvβ6 Antibodies Predict Pouchitis in Patients With Ulcerative Colitis After Restorative Proctocolectomy With Ileal Pouch-Anal Anastomosis., PMID:39657162
A trafficking regulatory subnetwork governs αVβ6 integrin-HER2 cross-talk to control breast cancer invasion and drug resistance., PMID:39630893
Anti-integrin αvβ6 antibody as a biomarker for diagnosing ulcerative colitis: a nationwide multicenter validation study., PMID:39607498
Anti-integrin αvβ6 autoantibody in primary sclerosing cholangitis: a Japanese nationwide study., PMID:39549066
Integrin αVβ6: Autoantigen and Driver of Epithelial Remodeling in Colon and Bile Ducts in Primary Sclerosing Cholangitis and Inflammatory Bowel Disease., PMID:39212221
Knockout of integrin αvβ6 protects against renal inflammation in chronic kidney disease by reduction of pro-inflammatory macrophages., PMID:38844455
Anti-integrin αvβ6 antibody in Takayasu arteritis patients with or without ulcerative colitis., PMID:38784377
Bispecific T cell engager-armed T cells targeting integrin ανβ6 exhibit enhanced T cell redirection and antitumor activity in cholangiocarcinoma., PMID:38744221
Anti-integrin αvβ6 autoantibodies are a potential biomarker for ulcerative colitis-like immune checkpoint inhibitor-induced colitis., PMID:38461170
Diagnostic value of anti-integrin αvβ6 antibodies in ulcerative colitis., PMID:37407314
ROS-responsive microneedles loaded with integrin avβ6-blocking antibodies for the treatment of pulmonary fibrosis., PMID:37331606
Anti-integrin αvβ6 autoantibodies in patients with primary sclerosing cholangitis., PMID:37310456
Anti-Integrin αvβ6 Autoantibodies Are a Novel Biomarker That Antedate Ulcerative Colitis., PMID:36634824
Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by Involving an Integrin-αVβ6/TGF-β Signaling Cascade., PMID:36268721
Anti-Integrin αvβ6 Antibody as a Diagnostic Marker for Pediatric Patients With Ulcerative Colitis., PMID:35709831
Combining a Universal Capture Ligand and Pan-Serotype Monoclonal Antibody to Develop a Pan-Serotype Lateral Flow Strip Test for Foot-and-Mouth Disease Virus Detection., PMID:35458515
Inhibition of Integrin αvβ6 Activation of TGF-β Attenuates Tendinopathy., PMID:35166070
Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer., PMID:35131862
Novel Diagnostic Autoantibodies Against Endothelial Protein C Receptor in Patients With Ulcerative Colitis., PMID:34971808
The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection., PMID:34910784
Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual αvβ6/αvβ8 Integrin Ligand., PMID:33961417
Identification of an Anti-Integrin αvβ6 Autoantibody in Patients With Ulcerative Colitis., PMID:33582126
Harnessing the power of foot-and-mouth-disease virus for targeting integrin alpha-v beta-6 for the therapy of cancer., PMID:33533659
Differential expression of αVβ3 and αVβ6 integrins in prostate cancer progression., PMID:33481853
Integrin αvβ6-TGFβ-SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer., PMID:33385331
Preclinical evaluation of [18F]FB-A20FMDV2 as a selective marker for measuring αVβ6 integrin occupancy using positron emission tomography in rodent lung., PMID:31897589
Systemic delivery and SPECT/CT in vivo imaging of 125I-labelled oncolytic adenoviral mutants in models of pancreatic cancer., PMID:31492884
Targeted magnetic nanoparticle hyperthermia for the treatment of oral cancer., PMID:31309616
The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy., PMID:31259422
Integrin αvβ6 mediates epithelial-mesenchymal transition in human bronchial epithelial cells induced by lipopolysaccharides of Pseudomonas aeruginosa via TGF-β1-Smad2/3 signaling pathway., PMID:31243731
Photo-crosslinked gelatin-hyaluronic acid methacrylate hydrogel-committed nucleus pulposus-like differentiation of adipose stromal cells for intervertebral disc repair., PMID:30808066
Initiation of fibrosis in the integrin Αvβ6 knockout mice., PMID:30500364
Integrins αvβ5 and αvβ6 Mediate IL-4-induced Collective Migration in Human Airway Epithelial Cells., PMID:30359079
Inhibition of integrin αVβ6 changes fibril thickness of stromal collagen in experimental carcinomas., PMID:29966518
Integrin expression and glycosylation patterns regulate cell-matrix adhesion and alter with breast cancer progression., PMID:29577899
Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer., PMID:29530483
A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18F-FB-A20FMDV2 for Imaging the Integrin αvβ6., PMID:29438002
Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus., PMID:29292384
Study on the effect of integrin ανβ6 on the proliferation and apoptosis of thyroid carcinoma cells., PMID:28730778
ImmunoPET Imaging of αvβ6 Expression Using an Engineered Anti-αvβ6 Cys-diabody Site-Specifically Radiolabeled with Cu-64: Considerations for Optimal Imaging with Antibody Fragments., PMID:28653240
The roles of integrin αvβ6 in cancer., PMID:28634043
Photoacoustic and Fluorescence Imaging of Cutaneous Squamous Cell Carcinoma in Living Subjects Using a Probe Targeting Integrin αvβ6., PMID:28181579
Integrins are not essential for entry of coxsackievirus A9 into SW480 human colon adenocarcinoma cells., PMID:27756316
For research use only. Not for human or drug use.
