Catalog No.
YHG87001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile489-Asp667
Predicted molecular weight
22.58 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14683
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DXS423E, SB1.8, KIAA0178, Structural maintenance of chromosomes protein 1A, SMC-1A, Sb1.8, SMC1, SMC1A, SMC protein 1A, SMC1L1, SMC-1-alpha
Investigation into the Spatial Heterogeneity of Lung Composite Large-Cell Neuroendocrine Carcinoma Spatial Transcriptomic Analysis of Combined Large-Cell Neuroendocrine Carcinoma., PMID:40304569
[Clinicopathological features of primary thoracic synovial sarcoma: a study of 42 cases]., PMID:40302578
Characteristics and clinical outcomes of patients with myeloid malignancies and cohesin mutations., PMID:40219906
Cohesin mutations and chromatin changes in cancer., PMID:40063003
Increased interferon I signaling, DNA damage response and evidence of T-cell exhaustion in a patient with combined interferonopathy (Aicardi-Goutières Syndrome, AGS) and cohesinopathy (Cornelia de Lange Syndrome, CdLS)., PMID:39871364
Association of Structural Maintenance of Chromosome-1A Phosphorylation with Progression of Breast Cancer., PMID:39851557
A De Novo Frameshift Variant in SMC1A Causes Non-Classic Cornelia de Lange Syndrome With Epilepsy: A Case Report and Literature Review., PMID:39831465
Identification of novel KRASG12D neoantigen specific TCRs and a strategy to eliminate off-target recognition., PMID:39819441
Genome Instability and Senescence Are Markers of Cornelia de Lange Syndrome Cells., PMID:39682772
Sensory-Motor Polyneuropathy in an 11-year- old Girl with a Pathogenic Variant in SMC1A: A Case Report., PMID:39542017
The Benefits of Whole-Exome Sequencing in the Differential Diagnosis of Hypophosphatasia., PMID:39519277
Sleep correlates of behavior functioning in Cornelia de Lange syndrome., PMID:39394947
A Novel De Novo STAG1 Variant in Monozygotic Twins with Neurodevelopmental Disorder: New Insights in Clinical Heterogeneity., PMID:39336775
Hsa_circ_0000092 up-regulates IL24 by SMC1A to induce macrophages M2 polarization., PMID:39296099
Cohesin mutations in acute myeloid leukemia., PMID:39251741
The cohesin ATPase cycle is mediated by specific conformational dynamics and interface plasticity of SMC1A and SMC3 ATPase domains., PMID:39240714
Psoriatic skin transcript phenotype: androgen/estrogen and cortisone/cortisol imbalance with increasing DNA damage response., PMID:39180588
RetSat stabilizes mitotic chromosome segregation in pluripotent stem cells., PMID:39172275
Structural Variants in the SMC1A Gene Associated With Near-Haploidy in Undifferentiated Pleomorphic Sarcomas., PMID:39149945
Subunit-specific analysis of cohesin-mutant myeloid malignancies reveals distinct ontogeny and outcomes., PMID:39033241
Cohesin composition and dosage independently affect early development in zebrafish., PMID:38975838
DCAF15 control of cohesin dynamics sustains acute myeloid leukemia., PMID:38961054
Identification of SMC2 and SMC4 as prognostic markers in breast cancer through bioinformatics analysis., PMID:38773061
Cornelia de Lange Spectrum., PMID:38735830
Treatment patterns, clinical outcomes and gene mutation characteristics of hepatitis B virus-associated mantle cell lymphoma., PMID:38676394
X-Linked Epilepsies: A Narrative Review., PMID:38612920
Synthetic Lethality between Cohesin and WNT Signaling Pathways in Diverse Cancer Contexts., PMID:38607047
High Clinical Exome Sequencing Diagnostic Rates and Novel Phenotypic Expansions for Nonisolated Microphthalmia, Anophthalmia, and Coloboma., PMID:38502138
Neurobehavioral and developmental profiles: genotype-phenotype correlations in individuals with Cornelia de Lange syndrome., PMID:38462617
SMC1A epilepsy syndrome: clinical data from a large international cohort., PMID:38421079
Sulfotransferase SULT2B1 facilitates colon cancer metastasis by promoting SCD1-mediated lipid metabolism., PMID:38372484
The synergism of SMC1A cohesin gene silencing and bevacizumab against colorectal cancer., PMID:38365745
AKT/FOXM1/STMN1 signaling pathway activation by SMC1A promotes tumor growth in breast cancer., PMID:38282144
Comprehensive review and expanding the genetic landscape of Cornelia-de-Lange spectrum: insights from novel mutations and skin biopsy in exome-negative cases., PMID:38216990
A study on genotypes and phenotypes of short stature caused by epigenetic modification gene variants., PMID:38170291
Distinct karyotypic and mutational landscape in trisomy AML., PMID:38054248
PRAME induces genomic instability in uveal melanoma., PMID:38030788
XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes., PMID:37939182
CRISPR-Cas9-based functional interrogation of unconventional translatome reveals human cancer dependency on cryptic non-canonical open reading frames., PMID:37932451
SMC1A facilitates gastric cancer cell proliferation, migration, and invasion via promoting SNAIL activated EMT., PMID:37537540
Pneumonia-Induced Thyroid Crisis With Thyrotoxicosis Exacerbation: De Novo Graves' Disease Presentation on a Cornelia de Lange Syndrome (CdLS)., PMID:37519569
Genomic analyses in Cornelia de Lange Syndrome and related diagnoses: Novel candidate genes, genotype-phenotype correlations and common mechanisms., PMID:37377026
PIK3R3 is upregulated in liver cancer and activates Akt signaling to control cancer growth by regulation of CDKN1C and SMC1A., PMID:37212524
[Analysis of clinical phenotype and pathogenic variant of a fetus with Cornelia de Lange syndrome type II]., PMID:37102291
Effects of SMC1A on immune microenvironment and cancer stem cells in colon adenocarcinoma., PMID:37096492
Fetal phenotype of Cornelia de Lange syndrome with a molecular confirmation., PMID:36913886
Alterations of cohesin complex genes in acute myeloid leukemia: differential co-mutations, clinical presentation and impact on outcome., PMID:36693840
Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming., PMID:36669113
[Analysis of genotypes and phenotypes of three children with Cornelia de Lange syndrome]., PMID:36584992
Bioinformatic Analysis of Plus Gene Expression Related to Progression from Leukoplakia to Oral Squamous Cell Carcinoma., PMID:36444596