Catalog No.
YHN05601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser332-Ser663
Predicted molecular weight
38.67 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99558
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NF-kappa-beta-inducing kinase, NIK, HsNIK, Mitogen-activated protein kinase kinase kinase 14, MAP3K14, Serine/threonine-protein kinase NIK
The Role of microRNAs in Lidocaine-Induced Spinal Cord Neurotoxicity: An Exploration Based on Bioinformatics Analysis., PMID:40014404
Nitrate activates an MKK3-dependent MAPK module via NLP transcription factors in Arabidopsis., PMID:39962336
Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance., PMID:39901302
Targeting NF-kappaB-inducing kinase shapes B-cell homeostasis in myasthenia gravis., PMID:39856699
Identification and study of new NF-κB-inducing kinase ligands derived from the imidazolone scaffold., PMID:39604268
NF-ΚB Activation as a Key Driver in Chronic Lymphocytic Leukemia Evolution to Richter's Syndrome: Unraveling the Influence of Immune Microenvironment Dynamics., PMID:39596634
NIK Is a Mediator of Inflammation and Intimal Hyperplasia in Endothelial Denudation-Induced Vascular Injury., PMID:39519026
Computational recognition of regulator genes and signature for ferroptosis with implications on immunological properties and clinical management of atopic dermatitis., PMID:39308857
Inhibiting NF-κB inducing kinase improved the motor performance of ALS animal model., PMID:39019135
NF-κB Inducing Kinase Attenuates Colorectal Cancer by Regulating Noncanonical NF-κB Mediated Colonic Epithelial Cell Regeneration., PMID:38750899
Human T-cell lymphotropic virus type 1 (HTLV-1) grip on T-cells: investigating the viral tapestry of activation., PMID:38734673
Potential Role of MAP3K14 in Hepatocellular Carcinoma: A Study Based on Comprehensive Bioinformatical Analysis and Validation., PMID:38577603
Dysregulated lncRNAs regulate human umbilical cord mesenchymal stem cell differentiation into insulin-producing cells by forming a regulatory network with mRNAs., PMID:38273351
Expression profiles of lncRNAs, miRNAs, and mRNAs during the proliferative phase of liver regeneration in mice with liver fibrosis., PMID:37722434
Transcriptional induction of NF-κB-inducing kinase by E2F4/5 facilitates collective invasion of GBM cells., PMID:37567906
NIK-mediated reactivation of SIX2 enhanced the CSC-like traits of hepatocellular carcinoma cells through suppressing ubiquitin-proteasome system., PMID:37461228
Comprehensive Analyses Revealed Eight Immune Related Signatures Correlated With Aberrant Methylations as Prognosis and Diagnosis Biomarkers for Kidney Renal Papillary Cell Carcinoma., PMID:37455213
EGR1 knockdown confers protection against ferroptosis and ameliorates intervertebral disc cartilage degeneration by inactivating the MAP3K14/NF-κB axis., PMID:37453477
Inhibition of non-canonical NF-κB signaling suppresses periodontal inflammation and bone loss., PMID:37143646
Exosome-mediated delivery of gga-miR-20a-5p regulates immune response of chicken macrophages by targeting IFNGR2, MAPK1, MAP3K5, and MAP3K14., PMID:36634655
NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition., PMID:36356831
Impairment of a NIK-SIX Feedback Axis Results in Dysregulation of Intestinal Immune Homeostasis and Promotes Early-onset Fatal Spontaneous Colitis., PMID:36190381
Icariin and Competing Endogenous RNA Network: A Potential Protective Strategy Against Contrast-Induced Acute Kidney Injury., PMID:35910780
Pharmacogenetic analysis of canonical versus noncanonical pathway of NF-kB in Crohn's disease patients under anti-tumor necrosis factor-α treatment., PMID:35852914
Urinary Sediment mRNA Level of CREBBP and CYBA in Children With Steroid-Resistant Nephrotic Syndrome., PMID:35173708
Silencing of α-N-acetylgalactosaminidase in the gastric cancer cells amplified cell death and attenuated migration, while the multidrug resistance remained unchanged., PMID:34816536
PELI1 promotes radiotherapy sensitivity by inhibiting noncanonical NF-κB in esophageal squamous cancer., PMID:34738714
Effects of maternal diet-induced obesity on metabolic disorders and age-associated miRNA expression in the liver of male mouse offspring., PMID:34663892
Road to Metastasis: The TWEAK Pathway as a Discriminant between Metastasizing and Non-Metastasizing Thick Melanomas., PMID:34638912
Whole-Genome Profiles of Malay Colorectal Cancer Patients with Intact MMR Proteins., PMID:34573430
Transcriptome based analysis of apoptosis genes in chickens co-infected with avian infectious bronchitis virus and pathogenic Escherichia coli., PMID:33889358
Chromatin conformation changes in peripheral blood can detect prostate cancer and stratify disease risk groups., PMID:33509203
BIRC3 and BIRC5: multi-faceted inhibitors in cancer., PMID:33413657
Identification of Crucial lncRNAs, miRNAs, mRNAs, and Potential Therapeutic Compounds for Polycystic Ovary Syndrome by Bioinformatics Analysis., PMID:33224973
Targeting NF-κB-Inducing Kinase (NIK) in Immunity, Inflammation, and Cancer., PMID:33187137
An enhanced genetic model of relapsed IGH-translocated multiple myeloma evolutionary dynamics., PMID:33057009
17-Aminogeldanamycin Inhibits Constitutive Nuclear Factor-Kappa B (NF-κB) Activity in Patient-Derived Melanoma Cell Lines., PMID:32466509
Wounding and Insect Feeding Trigger Two Independent MAPK Pathways with Distinct Regulation and Kinetics., PMID:32265268
NF-κB Signaling Regulates Physiological and Pathological Chondrogenesis., PMID:31842396
Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals., PMID:31703101
Molecular dynamics simulation and QM/MM calculation reveal the selectivity mechanism of type I 1/2 kinase inhibitors: the effect of intramolecular H-bonds and conformational restriction for improved selectivity., PMID:31657381
Biological and clinical implications of BIRC3 mutations in chronic lymphocytic leukemia., PMID:31371416
Ssc-novel-miR-106-5p reduces lipopolysaccharide-induced inflammatory response in porcine endometrial epithelial cells by inhibiting the expression of the target gene mitogen-activated protein kinase kinase kinase 14 (MAP3K14)., PMID:31242957
MAP3K kinases and kidney injury., PMID:31196660
Transcriptome profiling of longissimus thoracis muscles identifies highly connected differentially expressed genes in meat type sheep of India., PMID:31170190
Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management., PMID:30963600
NIK as a Druggable Mediator of Tissue Injury., PMID:30926358
A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB., PMID:30894749
NIK-IKK complex interaction controls NF-κB-dependent inflammatory activation of endothelium in response to LTβR ligation., PMID:30837284
Developing specific molecular biomarkers for thermal stress in salmonids., PMID:30326831
For research use only. Not for human or drug use.
