Anti-Mouse TREX1 Polyclonal Antibody

Catalog No.

PMJ67501

Species reactivity

Mouse

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse TREX1 (Met11-Ala223).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Three-prime repair exonuclease 1, 3.1.11.2, 3'-5' exonuclease TREX1, Trex1

Purification

Purified by antigen affinity column.

Accession

Q91XB0

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Expanding the spectrum of genetic causes of DNA-specific exonuclease TREX1 variants in thrombotic microangiopathy., PMID:40383229

Tissue factor promotes TREX1 protein stability to evade cGAS-STING innate immune response in pancreatic ductal adenocarcinoma., PMID:39658648

The SLE-associated TREX1-P212fs mutation disrupts ER association leading to type I interferonopathy., PMID:39621297

cGAS activation in classical dendritic cells causes autoimmunity in TREX1-deficient mice., PMID:39254994

Crizanlizumab for retinal vasculopathy with cerebral leukoencephalopathy in a phase II clinical study., PMID:38950286

The Expression Levels of TREX1 and IFN-α Are Associated with Immune Reconstitution in HIV-1-Infected Individuals., PMID:38675842

TREX1 531C/T Polymorphism and Autoantibodies Associated with the Immune Status of HIV-1-Infected Individuals., PMID:37298611

Analysis of clinical characteristics of children with Aicardi-Goutieres syndrome in China., PMID:35551623

cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE., PMID:33854495

Development of novel highly sensitive methods to detect endogenous cGAMP in cells and tissue., PMID:31982420

TREX1 531C>T Polymorphism is Associated with High Proviral Load Levels in HTLV-1-Infected Persons., PMID:31861565

Genetic contributors and soluble mediators in prediction of autoimmune comorbidity., PMID:31444033

A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response., PMID:31147550

[Familial chilblain lupus: Four cases spanning three generations]., PMID:30217686

TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia., PMID:30062819

DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice., PMID:28325644

Retinal vasculitis., PMID:26945335

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases., PMID:26371324

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome., PMID:26223655

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease., PMID:25848017

Familial chilblain lupus due to a novel mutation in the exonuclease III domain of 3' repair exonuclease 1 (TREX1)., PMID:25517357

Rare variants in the TREX1 gene and susceptibility to autoimmune diseases., PMID:24224166

Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study., PMID:24183309

Dysregulation of the immune system in Aicardi-Goutières syndrome: another example in a TREX1-mutated patient., PMID:23918923

Innate immune sensing of HIV-1 by dendritic cells., PMID:23084911

Type I IFN system in the development and manifestations of SLE., PMID:22832823

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations., PMID:22461318

Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population., PMID:22087647

Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease., PMID:22071149

Endogenous retroviral pathogenesis in lupus., PMID:20644481

Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome., PMID:20131292

Pathogenic mechanisms in systemic lupus erythematosus., PMID:20014960

Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir., PMID:19923437

Familial chilblain lupus--a monogenic form of cutaneous lupus erythematosus due to a heterozygous mutation in TREX1., PMID:19478477

The SET complex acts as a barrier to autointegration of HIV-1., PMID:19266025

The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease., PMID:18805785

Trex1 prevents cell-intrinsic initiation of autoimmunity., PMID:18724932

TREX1 polymorphisms associated with autoantibodies in patients with systemic lupus erythematosus., PMID:18092167

Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage., PMID:17638878

A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus., PMID:17440703

Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage., PMID:15527801

ATR-dependent phosphorylation of ATRIP in response to genotoxic stress., PMID:15451423

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