Catalog No.
PHJ84501
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human AKT3 (Met1-Lys143).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
PKBG,PKB gamma,AKT3,STK-2,Protein kinase B gamma,RAC-PK-gamma,RAC-gamma serine/threonine-protein kinase,Protein kinase Akt-3
Purification
Purified by antigen affinity column.
Accession
Q9Y243
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Differential response of IgM and IgG memory B cell populations to CD40L: insights of T cell - memory B cell interactions., PMID:39050849
K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3., PMID:38291468
Baseline tumor gene expression signatures correlate with chemoimmunotherapy treatment responsiveness in canine B cell lymphoma., PMID:37624862
Plasma microRNA-195, -34c, and - 1246 as novel biomarkers for the diagnosis of trastuzumab-resistant HER2-positive breast cancer patients., PMID:37557922
Autoantibodies against PIP4K2B and AKT3 Are Associated with Skin and Lung Fibrosis in Patients with Systemic Sclerosis., PMID:36982700
FGFR1 Amplification and Response to Neoadjuvant Anti-HER2 Treatment in Early HER2-Positive Breast Cancer., PMID:35213975
Sevoflurane Modulates AKT Isoforms in Triple Negative Breast Cancer Cells. An Experimental Study., PMID:34199634
Toward a better definition of focal cortical dysplasia: An iterative histopathological and genetic agreement trial., PMID:33949696
PSMA conjugated combinatorial liposomal formulation encapsulating genistein and plumbagin to induce apoptosis in prostate cancer cells., PMID:33839474
Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis., PMID:33670586
Isoform- and Phosphorylation-specific Multiplexed Quantitative Pharmacodynamics of Drugs Targeting PI3K and MAPK Signaling in Xenograft Models and Clinical Biopsies., PMID:33536190
An AKT2-specific nanobody that targets the hydrophobic motif induces cell cycle arrest, autophagy and loss of focal adhesions in MDA-MB-231 cells., PMID:33378961
Akt isoform-specific effects on thyroid cancer development and progression in a murine thyroid cancer model., PMID:33110146
Development and characterization of protein kinase B/AKT isoform-specific nanobodies., PMID:33045011
Acquisition of chromosome 1q duplication in parental and genome-edited human-induced pluripotent stem cell-derived neural stem cells results in their higher proliferation rate in vitro and in vivo., PMID:32918782
Angiogenic and Immune-Related Biomarkers and Outcomes Following Axitinib/Pembrolizumab Treatment in Patients with Advanced Renal Cell Carcinoma., PMID:32816890
Transcriptomics analysis of pericytes from retinas of diabetic animals reveals novel genes and molecular pathways relevant to blood-retinal barrier alterations in diabetic retinopathy., PMID:32376470
Protein kinase Akt2/PKBβ is involved in blastomere proliferation of preimplantation mouse embryos., PMID:31552693
Akt3-Mediated Protection Against Inflammatory Demyelinating Disease., PMID:31404142
A B-cell receptor-related gene signature predicts response to ibrutinib treatment in mantle cell lymphoma cell lines., PMID:30819916
Evaluation of the Insulin-like Growth Factor Receptor Pathway in Patients with Advanced Breast Cancer Treated with Trastuzumab., PMID:30343280
AKT2 is the predominant AKT isoform expressed in human skeletal muscle., PMID:29595878
A B-cell receptor-related gene signature predicts survival in mantle cell lymphoma: results from the Fondazione Italiana Linfomi MCL-0208 trial., PMID:29472356
Role of YAP1 as a Marker of Sensitivity to Dual AKT and P70S6K Inhibition in Ovarian and Uterine Malignancies., PMID:28376174
High early growth response 1 (EGR1) expression correlates with resistance to anti-EGFR treatment in vitro and with poorer outcome in metastatic colorectal cancer patients treated with cetuximab., PMID:28005260
Differential effects of peptidoglycan on colorectal tumors and intestinal tissue post-pelvic radiotherapy., PMID:27708223
Gene expression profiling of epithelial ovarian cancer reveals key genes and pathways associated with chemotherapy resistance., PMID:26909918
Knockdown of AKT3 and PI3KCA by RNA interference changes the expression of the genes that are related to apoptosis and autophagy in T98G glioblastoma multiforme cells., PMID:26481529
Anti-PD-1 and PD-L1 therapy for bladder cancer: what is on the horizon?, PMID:26260808
Knockdown of the AKT3 (PKBγ), PI3KCA, and VEGFR2 genes by RNA interference suppresses glioblastoma multiforme T98G cells invasiveness in vitro., PMID:25501707
Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells., PMID:24550521
Specific plasma autoantibody reactivity in myelodysplastic syndromes., PMID:24264604
AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1., PMID:24081905
Identification and quantification of AKT isoforms and phosphoforms in breast cancer using a novel nanofluidic immunoassay., PMID:23929892
Pancreatic secretory trypsin inhibitor causes autocrine-mediated migration and invasion in bladder cancer and phosphorylates the EGF receptor, Akt2 and Akt3, and ERK1 and ERK2., PMID:23698120
AKT isoforms 1 and 3 regulate basal and epidermal growth factor-stimulated SGHPL-5 trophoblast cell migration in humans., PMID:23303682
BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin., PMID:22391142
Activation of protein kinase B/Akt by alpha1-adrenoceptors in the human prostate., PMID:22280833
Expression, localization, and phosphorylation of Akt1 in benign and malignant thyroid lesions., PMID:21898122
The use of protein array to identify targetable receptor tyrosine kinases for treatment of human colon cancer., PMID:20811704
The Akt isoforms are present at distinct subcellular locations., PMID:20018949
High resolution genome-wide analysis of chromosomal alterations in Burkitt's lymphoma., PMID:19759907
Insulin-like growth factor-1 promotes G(1)/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase/Akt pathway in developing rat cerebral cortex., PMID:19158303
Effects of ERBB2 amplicon size and genomic alterations of chromosomes 1, 3, and 10 on patient response to trastuzumab in metastatic breast cancer., PMID:17243161
Proapoptotic activity of cell-permeable anti-Akt single-chain antibodies., PMID:15805282
Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles., PMID:15753124
Inactivation of GSK-3beta in okadaic acid-induced neurodegeneration: relevance to Alzheimer's disease., PMID:15706224
Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors., PMID:15456405
Human intestinal epithelial cell survival and anoikis. Differentiation state-distinct regulation and roles of protein kinase B/Akt isoforms., PMID:15299029
Analysis of DNA copy number aberrations in hepatitis C virus-associated hepatocellular carcinomas by conventional CGH and array CGH., PMID:15133472
For research use only. Not for human or drug use.
