Catalog No.
YMN07301
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Gly13-Thr220
Predicted molecular weight
25.65 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q19AB2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ROBO2 isoform b, Roundabout guidance receptor 2, Robo2
Exploring causal plasma protein level ratios and potential drug targets for depression: A proteomics Mendelian randomization study., PMID:40499826
Slit-Robo signaling supports motor neuron avoidance of the spinal cord midline through DCC antagonism and other mechanisms., PMID:40276653
A neuronal Slit1-dependent program rescues oligodendrocyte differentiation and myelination under chronic hypoxic conditions., PMID:40117292
Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells., PMID:39565875
Whole‑exome sequencing insights into synchronous bilateral breast cancer with discordant molecular subtypes., PMID:39430730
Role of Csdc2 in Regulating Secondary Hair Follicle Growth in Cashmere Goats., PMID:39125915
Genetic architecture of the toxicological response to eucalyptol and citronellal in Drosophila melanogaster., PMID:38879329
Overexpression of miR-25 Downregulates the Expression of ROBO2 in Idiopathic Intellectual Disability., PMID:38612763
Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates axon guidance genes in Drosophila., PMID:38381741
A mismatch in the expression of cell surface molecules induces tissue-intrinsic defense against aberrant cells., PMID:38350446
Downregulation of Roundabout guidance receptor 2 suppresses hepatocellular carcinoma progression by interacting with Y-box binding protein 1., PMID:38297025
Genome-Wide Association Studies of 3 Distinct Recovery Phenotypes in Mild Ischemic Stroke., PMID:38181310
Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging., PMID:38173016
Cord blood-derived biologics lead to robust axonal regeneration in benzalkonium chloride-injured mouse corneas by modulating the Il-17 pathway and neuropeptide Y., PMID:38172658
Islet architecture in adult mice is actively maintained by Robo2 expression in β cells., PMID:37972678
INF2 and ROBO2 gene mutation in an Indian family with end stage renal failure and follow-up of renal transplantation., PMID:37772439
Evolutionary conserved circular MEF2A RNAs regulate myogenic differentiation and skeletal muscle development., PMID:37676887
SALL4 advances the proliferation and tumor cell stemness of colon cancer cells through the transcription and regulation of ROBO2., PMID:37660281
Transcriptomic analysis of ovarian follicles uncovers the crucial genes relevant to follicle selection and preovulatory hierarchy in hens., PMID:37453139
Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing in Chinese patients., PMID:37418076
SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing., PMID:37311584
The SLIT/ROBO Pathway in Liver Fibrosis and Cancer., PMID:37238655
Slit-Robo expression in the leech nervous system: insights into eyespot evolution., PMID:37013648
Inhibition of MAPK/ERK pathway activation rescues congenital anomalies of the kidney and urinary tract (CAKUT) in Robo2PB/+ Gen1PB/+ mice., PMID:36870240
Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates the axon guidance genes robo2 and slit in Drosophila., PMID:36824980
Robo2 promotes osteoblast differentiation and mineralization through autophagy and is activated by parathyroid hormone induction., PMID:36801365
Zebrafish sox2 Is Required for the Swim Bladder Inflation by Controlling the Swim-Up Behavior., PMID:36795618
Identification of Novel Biomarkers for Abdominal Aortic Aneurysm Promoted by Obstructive Sleep Apnea., PMID:36739079
Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates axon guidance genes in Drosophila., PMID:36711932
Catechol-O-methyl transferase suppresses cell invasion and interplays with MET signaling in estrogen dependent breast cancer., PMID:36690660
Genome-Wide Association Study Identifies ROBO2 as a Novel Susceptibility Gene for Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors., PMID:36508697
Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux., PMID:36417404
Genome-wide association study meta-analysis of suicide death and suicidal behavior., PMID:36253440
Characterization of enhancer fragments in Drosophila robo2., PMID:36217698
Transcriptomic Immune Profiles Can Represent the Tumor Immune Microenvironment Related to the Tumor Budding Histology in Uterine Cervical Cancer., PMID:36011316
Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding., PMID:35940226
The Profile of MicroRNA Expression and Potential Role in the Regulation of Drug-Resistant Genes in Doxorubicin and Topotecan Resistant Ovarian Cancer Cell Lines., PMID:35628654
Circ_ROBO2/miR-186-5p/TRIM14 axis regulates oxidized low-density lipoprotein-induced cardiac microvascular endothelial cell injury., PMID:35620639
An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations., PMID:35584116
Weighted Single-Step Genome-Wide Association Study Uncovers Known and Novel Candidate Genomic Regions for Milk Production Traits and Somatic Cell Score in Valle del Belice Dairy Sheep., PMID:35565582
Proteomic Analysis of Plasma Markers in Patients Maintained on Antipsychotics: Comparison to Patients Off Antipsychotics and Normal Controls., PMID:35546954
Tissue-Specific Roles for the Slit-Robo Pathway During Heart, Caval Vein, and Diaphragm Development., PMID:35343246
Finding New Ways How to Control BACE1., PMID:35305135
Replication of gene polymorphisms associated with periodontitis-related traits in an elderly cohort: the Washington Heights/Inwood Community Aging Project Ancillary Study of Oral Health., PMID:35179257
Robo2 Drives Target-Selective Peripheral Nerve Regeneration in Response to Glia-Derived Signals., PMID:34916258
Soluble TREM-1, as a new ligand for the membrane receptor Robo2, promotes hepatic stellate cells activation and liver fibrosis., PMID:34750987
Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function., PMID:34686348
Circ_ROBO2/miR-149 Axis Promotes the Proliferation and Migration of Human Aortic Smooth Muscle Cells by Activating NF-κB Signaling., PMID:34649241
Ductular reaction promotes intrahepatic angiogenesis through Slit2-Roundabout 1 signaling., PMID:34490644
Modeling HNF1B-associated monogenic diabetes using human iPSCs reveals an early stage impairment of the pancreatic developmental program., PMID:34450036
For research use only. Not for human or drug use.
