Catalog No.
YMG76001
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Thr20-Pro228
Predicted molecular weight
25.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O35228
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Interleukin-27 subunit beta, IL-27 subunit beta, IL-27B, Epstein-Barr virus-induced gene 3 protein homolog, Ebi3, Il27b
Integrating Transcriptomic and Proteomic Data: IL-27B as a Key Protein in the Development of Septic Cardiomyopathy-A Retrospective Study., PMID:40396598
High interleukin-35 expression is associated with the severity of rheumatic mitral stenosis., PMID:40264784
Malignant behaviors and immune response in melanoma: Epstein-Barr virus induced gene 3 as a therapeutic target based on an in-vitro exploration., PMID:39726752
Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions., PMID:37878703
Epstein-Barr virus-induced gene 3 commits human mesenchymal stem cells to differentiate into chondrocytes via endoplasmic reticulum stress sensor., PMID:36548354
Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis., PMID:35986791
Epstein-Barr Virus-induced Gene 3 as a Novel Biomarker in Metastatic Melanoma With Infiltrating CD8+ T Cells: A Study Based on The Cancer Genome Atlas (TCGA)., PMID:34969761
Multifaceted Analysis of IL-23A- and/or EBI3-Including Cytokines Produced by Psoriatic Keratinocytes., PMID:34884474
IL-35 subunit EBI3 alleviates bleomycin-induced pulmonary fibrosis via suppressing DNA enrichment of STAT3., PMID:34711217
A Chaperone-Like Role for EBI3 in Collaboration With Calnexin Under Inflammatory Conditions., PMID:34603342
Combining single-cell sequencing to identify key immune genes and construct the prognostic evaluation model for colon cancer patients., PMID:34323426
Mycobacterium tuberculosis (MTB) antigen-induced upregulation of interleukin-35 expression in patients with MTB infection: In vitro blockade of the effects of interleukin-35 on T lymphocyte subsets., PMID:34245560
Epigenetic DNA Methylation of EBI3 Modulates Human Interleukin-35 Formation via NFkB Signaling: A Promising Therapeutic Option in Ulcerative Colitis., PMID:34069352
The effects and mechanism of α-mangostin on chemosensitivity of gastric cancer cells., PMID:34003591
Analysis for interaction between interleukin-35 genes polymorphisms and risk factors on susceptibility to coronary heart disease in the Chinese Han population., PMID:33407151
Systemic transcriptome comparison between early- And late-onset pre-eclampsia shows distinct pathology and novel biomarkers., PMID:33332660
HSP70-Homolog DnaK of Pseudomonas aeruginosa Increases the Production of IL-27 through Expression of EBI3 via TLR4-Dependent NF-κB and TLR4-Independent Akt Signaling., PMID:33276561
Reduced IL-35 in patients with immune thrombocytopenia., PMID:33141778
Interleukin-35 in idiopathic inflammatory myopathies., PMID:33128920
Epstein-Barr virus-induced gene 3 (EBI3) single nucleotide polymorphisms and their association with central obesity and risk factors for cardiovascular disease: The GEA study., PMID:32763760
The contribution from interleukin-27 towards rheumatoid inflammation: insights from gene expression., PMID:32518420
Human neutrophils activated by TLR8 agonists, with or without IFNγ, synthesize and release EBI3, but not IL-12, IL-27, IL-35, or IL-39., PMID:32480433
Epigenetic histone modulation contributes to improvements in inflammatory bowel disease via EBI3., PMID:31955243
Treatment with rapamycin can restore regulatory T-cell function in IPEX patients., PMID:31874182
Stat3-mTOR signaling mediates the stimulation of GLP-1 production induced by IL-27., PMID:31426028
Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35., PMID:31264967
Association between Interleukin 35 Gene Single Nucleotide Polymorphisms and Systemic Lupus Erythematosus in a Chinese Han Population., PMID:31013577
The IL-23p19/EBI3 heterodimeric cytokine termed IL-39 remains a theoretical cytokine in man., PMID:30989239
Increased expression of the immunosuppressive interleukin-35 in patients with non-small cell lung cancer., PMID:30956278
Genetic polymorphism in association with susceptibility to tuberculosis: a study in a Pakistani population., PMID:30805894
Genetic loci for alcohol-related life events and substance-induced affective symptoms: indexing the "dark side" of addiction., PMID:30718457
Interleukin-35 in immune-related diseases: protection or destruction., PMID:30681737
Aberrant IL-35 levels in patients with primary Sjogren's syndrome., PMID:30589451
Decreased Gene Expression of Epstein-Barr Virus-Induced Gene 3 (EBI-3) may Contribute to the Pathogenesis of Rheumatoid Arthritis., PMID:30513021
[Expression and significance of interleukin-35 in lesion tissue of oral lichen planus patients]., PMID:29972958
Diminished circulating concentration of interleukin-35 in Helicobacter pylori-infected patients with peptic ulcer: Its association with FOXP3 gene polymorphism, bacterial virulence factor CagA, and gender of patients., PMID:29938865
Association between interleukin-35 polymorphisms and coronary heart disease in the Chinese Zhuang population: a case-control study., PMID:29738342
Upregulated EBI3 Correlates with Poor Outcome and Tumor Progression in Breast Cancer., PMID:29485413
MEK-ERK signaling diametrically controls the stimulation of IL-23p19 and EBI3 expression in epithelial cells by IL-36γ., PMID:29474749
Lower Plasma Levels of IL-35 in Patients with Primary Biliary Cirrhosis., PMID:29445068
Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation., PMID:29176764
Interleukin 35 Expression Correlates With Microvessel Density in Pancreatic Ductal Adenocarcinoma, Recruits Monocytes, and Promotes Growth and Angiogenesis of Xenograft Tumors in Mice., PMID:28989066
Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients., PMID:28738904
Effect of EBI3 on radiation-induced immunosuppression of cervical cancer HeLa cells by regulating Treg cells through PD-1/PD-L1 pathway., PMID:28351328
Soluble serum VCAM-1, whole blood mRNA expression and treatment response in natalizumab-treated multiple sclerosis., PMID:27919501
Elevated level of interleukin-35 in colorectal cancer induces conversion of T cells into iTr35 by activating STAT1/STAT3., PMID:27682874
An IL-27/Stat3 axis induces expression of programmed cell death 1 ligands (PD-L1/2) on infiltrating macrophages in lymphoma., PMID:27564404
Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway., PMID:27247488
Protective role of Interleukin 27 (IL-27) gene polymorphisms in patients with ulcerative colitis., PMID:26905929
Interleukin-35 is upregulated in response to influenza virus infection and secondary bacterial pneumonia., PMID:26844658
For research use only. Not for human or drug use.
