Catalog No.
YME74301
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Tyr1840-Ala2000
Predicted molecular weight
21.06 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9ERU9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
E3 SUMO-protein ligase RanBP2, 2.3.2.-, Ran-binding protein 2, RanBP2, Ranbp2
Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity., PMID:40462900
Bioprospecting potential genetic biomarkers of gallbladder cancer., PMID:40439781
A SUMO-interacting motif in the guanine nucleotide exchange factor EPAC1 is required for subcellular targeting and function., PMID:40412525
Epithelioid Inflammatory Myofibroblastic Sarcoma: Case Series With a First Report of CLTC::ALK Fusion in an Aggressive Disease., PMID:40386890
Interaction networks of SIM-binding groove mutants reveal alternate modes of SUMO binding and profound impact on SUMO conjugation., PMID:40367183
Clofoctol impairs the stemness of gastric cancer and induces TNF-mediated necroptosis by directly binding to RanBP2., PMID:40325218
TSPYL5-driven G3BP1 nuclear membrane translocation facilitates p53 cytoplasm sequestration via accelerating RanBP2-mediated p53 sumoylation and nuclear export in neuroblastoma., PMID:40319028
Anesthetic Management of a Patient With Acute Necrotizing Encephalopathy Type 1., PMID:40291183
Nuclear pore complex protein RANBP2 and related SUMOylation in solid malignancies., PMID:40271196
Nup358 and Nup153 Facilitate nuclear import of BmNPV nucleocapsids in Bombyx mori cells., PMID:40120667
Parvimonas micra promotes oral squamous cell carcinoma metastasis through TmpC-CKAP4 axis., PMID:40055343
Interplay between the cyclophilin homology domain of RANBP2 and MX2 regulates HIV-1 capsid dependencies on nucleoporins., PMID:39853118
Linear ubiquitination at damaged lysosomes induces local NFKB activation and controls cell survival., PMID:39744815
Clinical and genetic characteristics of RANBP2 mutations in children with acute necrotizing encephalopathy., PMID:39710814
The nucleoporin Nup153 is the anchor for Kif1a during basal nuclear migration in brain progenitor cells., PMID:39666457
Circular RNA-encoded oncogenic PIAS1 variant blocks immunogenic ferroptosis by modulating the balance between SUMOylation and phosphorylation of STAT1., PMID:39334380
Glia maturation factor-γ regulates amyloid-β42 phagocytosis through scavenger receptor class A type I in murine macrophages., PMID:39243388
Association of RAN and RANBP2 Gene Polymorphisms With Glioma Susceptibility in Chinese Children., PMID:39041645
Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling., PMID:39026009
Antibody-assisted selective isolation of Purkinje cell nuclei from mouse cerebellar tissue., PMID:38981474
Inflammatory myofibroblastic tumor from molecular diagnostics to current treatment., PMID:38948020
Personal essay of a rookie's journey with Bill Pak and his legacy: tales and perspectives on PI-PLC, NorpA and cyclophilin, NinaA - William L. Pak, PhD., 1932-2023: in memoriam., PMID:38913811
Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation., PMID:38838144
Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain., PMID:38657106
Cold-induced FOXO1 nuclear transport aids cold survival and tissue storage., PMID:38570500
Exercise-Induced Reduction of IGF1R Sumoylation Attenuates Neuroinflammation in APP/PS1 Transgenic Mice., PMID:38565402
Proteostatic remodeling of small heat shock chaperones - crystallins by Ran-binding protein 2 and the peptidyl-prolyl cis-trans isomerase and chaperone activities of its cyclophilin domain., PMID:38352504
RanBP2/Nup358 Mediates Sumoylation of STAT1 and Antagonizes Interferon-α-Mediated Antiviral Innate Immunity., PMID:38203469
Nuclear pore pathology underlying multisystem proteinopathy type 3-related inclusion body myopathy., PMID:38158701
Abdominal inflammatory myofibroblastic tumour: Clinicopathological and molecular analysis of 20 cases, highlighting potential therapeutic targets., PMID:38155480
A Rare Case of COVID-19 Related Acute Necrotizing Encephalopathy With the RANBP2 Mutation in a Pediatric Patient., PMID:38091492
Defining the Clinicoradiologic Syndrome of SARS-CoV-2 Acute Necrotizing Encephalopathy: A Systematic Review and 3 New Pediatric Cases., PMID:38086061
Rapid and inexpensive bedside diagnosis of RAN binding protein 2-associated acute necrotizing encephalopathy., PMID:38046586
Distinct Mitotic Functions of Nucleolar and Spindle-Associated Protein 1 (NuSAP1) Are Controlled by Two Consensus SUMOylation Sites., PMID:37947624
A 5-year-old boy with super-refractory status epilepticus and RANBP2 variant warranting life-saving hemispherotomy., PMID:37943122
RANBP2 evolution and human disease., PMID:37795679
CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications., PMID:37640697
Nucleocytoplasmic transport at the crossroads of proteostasis, neurodegeneration and neuroprotection., PMID:37597509
Phosphoproteomics Reveal New Candidates in Abnormal Spermatogenesis of Pseudomales in Cynoglossus semilaevis., PMID:37511189
Exploring the molecular and clinical spectrum of COVID-19-related acute necrotizing encephalopathy in three pediatric cases., PMID:37491516
Cellular gp96 upregulates AFP expression by blocking NR5A2 SUMOylation and ubiquitination in hepatocellular carcinoma., PMID:37204028
Biallelic variants in ribonuclease inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute, necrotizing encephalopathy., PMID:37191094
BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M., PMID:37105961
De novo RANBP2 variant in a fetal demise case with cerebral intraparenchymal hemorrhage., PMID:37102432
RNA-binding proteins that lack canonical RNA-binding domains are rarely sequence-specific., PMID:37002329
Letter to the Editor in response to Dr. Josef Finsterer et al. "Intense work-up is required for pediatric COVID-related acute necrotizing encephalopathy with RANBP2 variants"., PMID:36990949
Hypoxia-induced degradation of PICK1 by RBCK1 promotes the proliferation of nasopharyngeal carcinoma cells., PMID:36934971
Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders., PMID:36930595
SUMOylated IL-33 in the nucleus stabilizes the transcription factor IRF1 in hepatocellular carcinoma cells to promote immune escape., PMID:36917642
Intense work-up is required for pediatric COVID-related acute necrotizing encephalopathy with RANBP2 variants., PMID:36857971
For research use only. Not for human or drug use.
