Catalog No.
YHN50201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Tyr181
Predicted molecular weight
22.31 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
A1A4Y4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Immunity-related GTPase family M protein, 3.6.5.-, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LPS-stimulated RAW 264.7 macrophage protein 47 homolog, LRG-47, IRGM, IFI1, IRGM1, LRG47
Type I interferon signaling and peroxisomal dysfunction contribute to enhanced inflammatory cytokine production in IRGM1-deficient macrophages., PMID:39395806
Type I IFN signaling in the absence of IRGM1 promotes M. tuberculosis replication in immune cells by suppressing T cell responses., PMID:39038752
IRGM/Irgm1 increases autophagy to inhibit activation of NLRP3 inflammasome in inflammatory injury induced acute liver failure., PMID:38849356
N-ethyl-N-nitrosourea (ENU)-induced C-terminal truncation of Runx3 results in autoimmune colitis associated with Th17/Treg imbalance., PMID:38788802
Enhanced protein-metabolite correlation analysis: To investigate the association between Staphylococcus aureus mastitis and metabolic immune pathways., PMID:38568835
Impact of IRGM gene promoter polymorphisms on susceptibility to chronic HBV infection., PMID:38514898
Fibroblast growth factor 21 mitigates lupus nephritis progression via the FGF21/Irgm 1/NLRP3 inflammasome pathway., PMID:38508095
Irgm proteins attenuate inflammatory disease in mouse models of genital Chlamydia infection., PMID:38501887
PRKAA2, MTOR, and TFEB in the regulation of lysosomal damage response and autophagy., PMID:38183492
Unveiling Circular RNA-Mediated Regulatory Mechanisms in Necroptosis in Premature Ovarian Failure., PMID:38062819
IRGM is a novel regulator of PD-L1 via promoting S6K1-mediated phosphorylation of YBX1 in hepatocellular carcinoma., PMID:37993085
Genes associated with inflammation for prognosis prediction for clear cell renal cell carcinoma: a multi-database analysis., PMID:37969384
Epithelial Cell NOD1/IRGM Recruits STX17 to Neisseria gonorrhoeae-Containing Endosomes to Initiate Lysosomal Degradation., PMID:37926090
Transgenic mouse models support a protective role of type I IFN response in SARS-CoV-2 infection-related lung immunopathology and neuroinvasion., PMID:37874678
TAOK3 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance Through Augmenting Autophagy Mediated by IRGM., PMID:37705061
Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease., PMID:37700498
Autophagy-related LncRNA PRDM10-DT responds to UVB radiation in keratinocytes., PMID:37566921
Race-specific association of an IRGM risk allele with cytokine expression in human subjects., PMID:37558924
How autophagy, a potential therapeutic target, regulates intestinal inflammation., PMID:37168865
The emerging roles of autophagy in intestinal epithelial cells and its links to inflammatory bowel disease., PMID:37052218
Evaluation of Immunity-related GTPase Family M Protein (IRGM) SNPs among Egyptian Lupus Patients: A Case-control Study., PMID:36999177
Human placental extract regulates polarization of macrophages via IRGM/NLRP3 in allergic rhinitis., PMID:36746096
Comparative Genetic Association Analysis of Human Genetic Susceptibility to Pulmonary and Lymph Node Tuberculosis., PMID:36672948
Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice., PMID:36629440
RIPosomes are targets of IRGM-SQSTM1-dependent autophagy., PMID:36628446
IRGM/Irgm1 deficiency inhibits neutrophil-platelet interactions and thrombosis in experimental atherosclerosis and arterial injury., PMID:36580725
Development and validation of the prognostic model based on autophagy-associated genes in idiopathic pulmonary fibrosis., PMID:36578501
Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection., PMID:36221902
Lactobacillusjohnsonii L531 Protects against Salmonella Infantis-Induced Intestinal Damage by Regulating the NOD Activation, Endoplasmic Reticulum Stress, and Autophagy., PMID:36142312
SILAC-based chemoproteomics reveals a neoligan analogue as an anti-inflammatory agent targeting IRGM to ameliorate cytokine storm., PMID:35970074
How did we get here? Insights into mechanisms of immunity-related GTPase targeting to intracellular pathogens., PMID:35963099
Association of IRGM promoter region polymorphisms and haplotype with pulmonary tuberculosis in Pakistani (Punjab) population., PMID:35939988
[Research updates: the mechanism of autophagy in inflammatory bowel disease]., PMID:35732613
Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis., PMID:35699756
Association of IRGM gene promoter polymorphisms with hepatitis B virus infection., PMID:35661332
Corrigendum to "AGBL2 promotes cancer cell growth through IRGM-regulated autophagy and enhanced Aurora A activity in hepatocellular carcinoma" [Canc. Lett. 414 (2018) 71-80]., PMID:35525812
The role of ATG16L2 in autophagy and disease., PMID:35239457
Effects of Herb-Partitioned Moxibustion on Autophagy and Immune Activity in the Colon Tissue of Rats with Crohn's Disease., PMID:35126598
Irgm1 regulates metabolism and function in T cell subsets., PMID:35039539
Analysis of rs1864182 and rs1864183 variants in ATG10 gene and antineutrophil cytoplasmic autoantibody-associated vasculitis in Chinese Guangxi population., PMID:34961976
3D disorganization and rearrangement of genome provide insights into pathogenesis of NAFLD by integrated Hi-C, Nanopore, and RNA sequencing., PMID:34729306
IRGM/Irgm1 facilitates macrophage apoptosis through ROS generation and MAPK signal transduction: Irgm1+/- mice display increases atherosclerotic plaque stability., PMID:34646375
Multifaceted pathogenesis of liver steatosis in inflammatory bowel disease: a systematic review., PMID:34604973
Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses., PMID:34467632
Murine Irgm Paralogs Regulate Nonredundant Functions To Execute Host Defense to Toxoplasma gondii., PMID:34338548
How autophagy controls the intestinal epithelial barrier., PMID:33906557
IRGM promotes melanoma cell survival through autophagy and is a promising prognostic biomarker for clinical application., PMID:33665357
Interferon-γ activated T-cell IRGM-autophagy axis in oral lichen planus., PMID:33639564
Caveolin-1 promotes radioresistance via IRGM-regulated autophagy in lung cancer., PMID:33553340
IRGM1 links mitochondrial quality control to autoimmunity., PMID:33510463
For research use only. Not for human or drug use.
