Catalog No.
YHN49801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser886-His1023
Predicted molecular weight
18.32 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q86YN6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Peroxisome proliferator-activated receptor gamma coactivator 1-beta, PGC-1-beta, PPAR-gamma coactivator 1-beta, PPARGC-1-beta, PGC-1-related estrogen receptor alpha coactivator, PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Astaxanthin supplementation in Arabian racing horses mitigates oxidative stress and inflammation in peripheral blood mononuclear cells through enhanced mitophagy., PMID:40287452
The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis., PMID:40056415
A Computational Recognition Analysis of Promising Prognostic Biomarkers in Breast, Colon and Lung Cancer Patients., PMID:39940786
Inhibition of the PI3K-AKT-MTORC1 axis reduces the burden of the m.3243A>G mtDNA mutation by promoting mitophagy and improving mitochondrial function., PMID:39667405
GLIS3: A novel transcriptional regulator of mitochondrial functions and metabolic reprogramming in postnatal kidney and polycystic kidney disease., PMID:39505148
Inhibitory Effect of Luteolin on Spike S1 Glycoprotein-Induced Inflammation in THP-1 Cells via the ER Stress-Inducing Calcium/CHOP/MAPK Pathway., PMID:39459041
Myeloid PGC1β attenuates high-fat-diet induced inflammation via mitochondrial fission/mtDNA/Nlrp3 pathway., PMID:39366644
Up-regulated mitochondrial biogenesis associated with GH/IGF axis in the ovaries of muskrats (Ondatra zibethicus)., PMID:39245261
Deciphering Early and Progressive Molecular Signatures in Alzheimer's Disease through Integrated Longitudinal Proteomic and Pathway Analysis in a Rodent Model., PMID:38928172
USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1β., PMID:38815879
Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma., PMID:38692271
Alterations in the molecular control of mitochondrial turnover in COPD lung and airway epithelial cells., PMID:38413800
miRNA-378 Is Downregulated by XBP1 and Inhibits Growth and Migration of Luminal Breast Cancer Cells., PMID:38203358
Human Genetic Variation at rs10071329 Correlates With Adiposity-Related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function., PMID:38190589
HLA-DQA1*05 and upstream variants of PPARGC1B are associated with infliximab persistence in Japanese Crohn's disease patients., PMID:37460671
Serotonin Transporter (SERT) Expression Modulates the Composition of the Western-Diet-Induced Microbiota in Aged Female Mice., PMID:37447374
Nanopore sequencing reveals methylation changes associated with obesity in circulating cell-free DNA from Göttingen Minipigs., PMID:37032646
Genetic and Epigenetic Regulation of the Innate Immune Response to Gout., PMID:36745138
LMP1 mediates tumorigenesis through persistent epigenetic modifications and PGC1β upregulation., PMID:36734290
miR136 regulates proliferation and differentiation of small tail han sheep preadipocytes., PMID:36722834
SIRT1/PGC-1α is involved in arsenic-induced male reproductive damage through mitochondrial dysfunction, which is blocked by the antioxidative effect of zinc., PMID:36681380
Association between PPARγ, PPARGC1A, and PPARGC1B genetic variants and susceptibility of gastric cancer in an Eastern Chinese population., PMID:36587194
Pectolinarigenin shows lipid-lowering effects by inhibiting fatty acid biosynthesis in vitro and in vivo., PMID:36415143
PGC-1β modulates catabolism and fiber atrophy in the fasting-response of specific skeletal muscle beds., PMID:36400401
Integrative analysis of differentially expressed mRNAs and proteins induced by PGC-1β in breast cancer cells., PMID:36375253
Genes Whose Gain or Loss of Function Changes Type 1, 2A, 2X, or 2B Muscle Fibre Proportions in Mice-A Systematic Review., PMID:36361732
Depicting the Implication of miR-378a in Cancers., PMID:36285472
Extracellular vesicles from oviductal and uterine fluids supplementation in sequential in vitro culture improves bovine embryo quality., PMID:36280872
Analysis of Metabolic Regulators PGC1-α and PGC1-β in Oral Squamous Cell Carcinoma with and without Hyperglycemia., PMID:36037136
Low expression of PGC-1β and other mitochondrial biogenesis modulators in melanoma is associated with growth arrest and the induction of an immunosuppressive gene expression program dependent on MEK and IRF-1., PMID:35594996
Adipose tissue-specific ablation of PGC-1β impairs thermogenesis in brown fat., PMID:35466996
Inflammasome genes polymorphisms and susceptibility to gout. Is there a link?, PMID:35313392
PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer., PMID:35131872
miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes., PMID:35094659
Genomic analysis to screen potential genes and mutations in children with non-syndromic early onset severe obesity: a multicentre study in Turkey., PMID:34850337
Histone Deacetylase 3 Regulates Adipocyte Phenotype at Early Stages of Differentiation., PMID:34502211
Decreased PGC1β expression results in disrupted human erythroid differentiation, impaired hemoglobinization and cell cycle exit., PMID:34429458
The current role of NLRP3 inflammasome polymorphism in gout susceptibility., PMID:34390315
Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects., PMID:34369602
Identification of the Functions and Prognostic Values of RNA Binding Proteins in Bladder Cancer., PMID:34239534
PI3K/AKT phosphorylation activates ERRα by upregulating PGC‑1α and PGC‑1β in gallbladder cancer., PMID:34184087
Global investigation of estrogen-responsive genes regulating lipid metabolism in the liver of laying hens., PMID:34107898
Regulatory Action of Plasma from Patients with Obesity and Diabetes towards Muscle Cells Differentiation and Bioenergetics Revealed by the C2C12 Cell Model and MicroRNA Analysis., PMID:34063883
UBQLN1 mediates sorafenib resistance through regulating mitochondrial biogenesis and ROS homeostasis by targeting PGC1β in hepatocellular carcinoma., PMID:34001851
Neuropeptide Y and its receptors are expressed in chicken skeletal muscle and regulate mitochondrial function., PMID:33961876
Construction and validation of an RNA-binding protein-associated prognostic model for colorectal cancer., PMID:33868829
Hepcidin-induced reduction in iron content and PGC-1β expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis., PMID:33820875
Muscle Transcriptome Analysis Reveals Molecular Pathways Related to Oxidative Phosphorylation, Antioxidant Defense, Fatness and Growth in Mangalitsa and Moravka Pigs., PMID:33809803
The miR-378/PGC1β/mTOR axis as an alternative mechanism to promote autophagy during adipogenesis., PMID:33716136
Effects of dried natto diet on the transcript levels of the peroxisome proliferator-activated receptor-γ, coactivator-1α and -1β, and nuclear receptor corepressor 1 genes in laying hens., PMID:33624372
For research use only. Not for human or drug use.
