Catalog No.
YHN49401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser320-Glu539
Predicted molecular weight
28.00 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BRK4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Leucine zipper putative tumor suppressor 2, Protein LAPSER1, LZTS2, KIAA1813, hLZTS2, LAPSER1
LZTS2 methylation as a potential diagnostic and prognostic marker in LIHC and STAD: Evidence from bioinformatics and in vitro analyses., PMID:40404727
α-Catenin force-sensitive binding and sequestration of LZTS2 leads to cytokinesis failure., PMID:39786338
Disrupting CCDC137-mediated LZTS2 and β-TrCP interaction in the nucleus inhibits hepatocellular carcinoma development via β-catenin and AKT., PMID:38918619
Phosphorylation of LZTS2 by PLK1 activates the Wnt pathway., PMID:38740232
EBV-encoded miRNAs BHRF1-1 and BART2-5p aggravate post- transplant lymphoproliferative disorder via LZTS2-PI3K-AKT axis., PMID:37419372
RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated β-catenin suppression., PMID:36750557
Lipid-induced monokine cyclophilin-A promotes adipose tissue dysfunction implementing insulin resistance and type 2 diabetes in zebrafish and mice models of obesity., PMID:35511344
LZTS2: A novel and independent prognostic biomarker for clear cell renal cell carcinoma., PMID:35287088
Long non-coding RNA linc00921 suppresses tumorigenesis and epithelial-to-mesenchymal transition of triple-negative breast cancer via targeting miR-9-5p/LZTS2 axis., PMID:35179718
A validation study of potential prognostic DNA methylation biomarkers in patients with acute myeloid leukemia using a custom DNA methylation sequencing panel., PMID:35148810
Proximity proteomics identifies PAK4 as a component of Afadin-Nectin junctions., PMID:34493720
Identification of differentially expressed genes and pathways crosstalk analysis in Rheumatoid and Osteoarthritis using next-generation sequencing and protein-protein networks., PMID:34354452
β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma., PMID:33420362
LZTS2 promoter hypermethylation: a potential biomarker for the diagnosis and prognosis of laryngeal squamous cell carcinoma., PMID:29499699
LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85., PMID:29409973
LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis., PMID:28323888
Prognostic methylation markers for overall survival in cytogenetically normal patients with acute myeloid leukemia treated on SWOG trials., PMID:28222251
The Shank3 Interaction Partner ProSAPiP1 Regulates Postsynaptic SPAR Levels and the Maturation of Dendritic Spines in Hippocampal Neurons., PMID:27252646
Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3., PMID:26364583
Distal 10q trisomy with copy number gain in chromosome region 10q23.1-10q25.1: the Wnt signaling pathway is the most pertinent to the gene content in the region of copy number gain: a case report., PMID:26088875
mir-300 promotes self-renewal and inhibits the differentiation of glioma stem-like cells., PMID:24464870
Leucine zipper tumor suppressor 2 inhibits cell proliferation and regulates Lef/Tcf-dependent transcription through Akt/GSK3β signaling pathway in lung cancer., PMID:23761130
Distribution and cluster analysis of predicted intrinsically disordered protein Pfam domains., PMID:28516017
Deletion of leucine zipper tumor suppressor 2 (Lzts2) increases susceptibility to tumor development., PMID:23275340
Lzts2 regulates embryonic cell movements and dorsoventral patterning through interaction with and export of nuclear β-catenin in zebrafish., PMID:22057270
The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development., PMID:21949185
The spatio-temporal expression of ProSAP/shank family members and their interaction partner LAPSER1 during Xenopus laevis development., PMID:21445960
Effect of the modulation of leucine zipper tumor suppressor 2 expression on proliferation of various cancer cells functions as a tumor suppressor., PMID:20890637
Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses., PMID:19703901
LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing., PMID:18490357
Differential effect of NF-kappaB activity on beta-catenin/Tcf pathway in various cancer cells., PMID:18242184
A screen of shRNAs targeting tumor suppressor genes to identify factors involved in A549 paclitaxel sensitivity., PMID:17982636
Crossregulation of beta-catenin/Tcf pathway by NF-kappaB is mediated by lzts2 in human adipose tissue-derived mesenchymal stem cells., PMID:17950943
The putative tumor suppressor Tsc-22 is downregulated early in chemically induced hepatocarcinogenesis and may be a suppressor of Gadd45b., PMID:17533171
LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin., PMID:17351128
LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin., PMID:17000760
In silico characterization of LZTS3, a potential tumor suppressor., PMID:16012743
LAPSER1: a novel candidate tumor suppressor gene from 10q24.3., PMID:11709705
For research use only. Not for human or drug use.
